Karen Clise-Dwyer

Mechanistic approach exploring combination agents to potentiate anti-leukemia activity of Hu8F4, a clinical stage T cell receptor mimic antibody

Анна Сергеева, Hong He, Lisa S. St. John, Ling Yu et autres

Abstract Hu8F4 is a T cell receptor (TCR)-mimic antibody that binds the leukemia-associated PR1/HLA-A2 complex overexpressed on HLA-A2+ leukemia cells. In a phase I dose escalation trial of Hu8F4 in patients with relapsed/refractory AML, MDS, and CMML, peripheral blast reduction following Hu8F4 …

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IMMU-91. Ligand receptor analyses of glioma immune microenvironment identifies Galectin-9 in microglia as regulator of tumor cell adhesion and phagocytosis

Pravesh Gupta, Silvana Valdebenito-Silva, Gayatri Kumar, Prashanth Chakrapani et autres

Abstract Innate immune cells of macrophage family predominate tumor immune microenvironment of CNS malignancies. Although macrophages exhibit myriads of protective functions such as clearance of malignant cells, immune surveillance, inflammation resolution and tissue repair, they are generally linked to immunosuppression in gliomas. …

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Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

Juan José Rodríguez‐Sevilla, Irene Gañán‐Gómez, Bijender Kumar, Natthakan Thongon et autres

Dissecting the preneoplastic disease states’ biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic stem …

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FLASH radiotherapy spares lymphocytes in tumor-draining lymph nodes and increases infiltration of immune cells in tumors

Francisco Sáenz, Brett Velasquez, T. J. Waldrop, Edgardo A Aguilar et autres

Abstract Radiotherapy (RT) delivered at conventional dose rates (CONV) can both stimulate antitumor immune responses and inhibit these immune responses by depleting circulating lymphocytes. Given the observed normal tissue sparing associated with ultra-high dose rate (FLASH) RT, we hypothesized that FLASH RT …

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Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant

Haven R. Garber, Danwei Wang, Céline Kerros, Hannah C. Beird et autres

ABSTRACT Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic leukemia (CLL) can result in cure in some patients. Analogous to chemotherapy and targeted therapy, we hypothesized that allogeneic cellular immunotherapies, including alloSCT and donor lymphocyte infusion (DLI), would impact …

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Cord-Derived Invariant Natural Killer T Cells As Novel Cell Therapy to Improve the Outcome of Hematopoietic Stem Cell Transplantation

Abel Trujillo‐Ocampo, Maison Grefe, Pâmella Borges, Jelita Clinton et autres

Allogeneic stem cell transplantation (ASCT) is a curative immunotherapy for patients with hematologic malignancies and performed more than 7000 per year in the US. Here, patients receive the conditioning chemo-radiation to eradicate the residual blood cancer, followed by donor stem cells to …

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The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan et autres

The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a …

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Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas

Pravesh Gupta, Minghao Dang, Shivangi Oberai, Simona Migliozzi et autres

BACKGROUND: Human gliomas are classified using isocitrate dehydrogenase (IDH) status as a prognosticator; however, the influence of genetic differences and treatment effects on ensuing immunity remains unclear. METHODS: In this study, we used sequential single-cell transcriptomics on 144 678 and spectral cytometry …

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Hu8F4-CAR T cells with mutated Fc spacer segment improve target specificity and mediate anti-leukemia activity in vivo

Hong He, Rolando A. Vedia, Sijie Lu, Qiaochuan Li et autres

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Abstract 44: A novel, codon-based method to modulate off-tumor toxicity of chimeric antigen receptor (CAR) T cells

Rolando A. Vedia, Sijie Lu, Anne V. Philips, Анна Сергеева et autres

Abstract Chimeric antigen receptor (CAR) T cell therapies for hematologic malignancies, while promising and efficacious, can also result in a variety of adverse effects. Of note, on-target, off-tumor toxicity is one adverse effect that continues to limit the safety and efficacy of …

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STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response

Bhakti Patel, Yifan Zhou, Rachel Lauren Babcock, Feiyang Ma et autres

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Hu8F4-CAR T cells with mutated Fc spacer segment improve target-specificity and mediate anti-leukemia activity in vivo

Jeffrey J. Molldrem, Hong He, Rolando Vedia, Sijie Lu et autres

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