S. Zakiah A. Talib

Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division

Nathan Palmer, Nisan Ece Kalem-Yapar, Hanna Hultén, Umur Keles et autres

In most mammals, the cell cycle kinase cyclin-dependent kinase 2 (CDK2) is expressed as two major isoforms as a result of alternative splicing. The shorter CDK2 isoform, CDK2S, is expressed constitutively during the cell cycle and can be detected in several tissues. …

at, se, de, sg, ru, us, cn, hk (code pays fourni par la source)

Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division

Nathan Palmer, S. Zakiah A. Talib, Jin Rong Ow, Tommaso Tabaglio et autres

Abstract In most mammals, the cell cycle kinase; cyclin-dependent kinase 2 (CDK2) is expressed as two major isoforms due to the inclusion or exclusion of an alternatively spliced exon. The shorter CDK2 isoform: CDK2S, is expressed constitutively during the cell cycle and …

at, de, sg, se, us, cn, hk (code pays fourni par la source)

Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity

Nathan Palmer, S. Zakiah A. Talib, Christine M. F. Goh, Kajal Biswas et autres

Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. The majority of CDK2's known meiotic functions occur during prophase of the first meiotic division. Here, CDK2 is involved in …

sg, at, de, us, se (code pays fourni par la source)

A novel function for CDK2 activity at meiotic crossover sites

Nathan Palmer, S. Zakiah A. Talib, Priti Singh, Christine M. F. Goh et autres

Genetic diversity in offspring is induced by meiotic recombination, which is initiated between homologs at >200 sites originating from meiotic double-strand breaks (DSBs). Of this initial pool, only 1-2 DSBs per homolog pair will be designated to form meiotic crossovers (COs), where …

sg, us, cn, hk, se (code pays fourni par la source)

Discovery of a chemical probe for PRDM9

Abdellah Allali‐Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna Leslie Organ et autres

Abstract PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results in altered meiotic gene transcription, impairment of double-stranded breaks and pairing …

ca, sg, us, lt (code pays fourni par la source)

Diverse roles for CDK‐associated activity during spermatogenesis

Nathan Palmer, S. Zakiah A. Talib, Philipp Kaldis

The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells …

sg, se (code pays fourni par la source)

CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I

Nathan Palmer, S. Zakiah A. Talib, Chandrahas Koumar Ratnacaram, Diana H. P. Low et autres

Meiosis generates four genetically distinct haploid gametes over the course of two reductional cell divisions. Meiotic divisions are characterized by the coordinated deposition and removal of various epigenetic marks. Here we propose that nuclear respiratory factor 1 (NRF1) regulates transcription of euchromatic …

sg (code pays fourni par la source)

Metabolic Remodeling during Liver Regeneration

Matias J. Caldez, Noémi Van Hul, Hiromi W.L. Koh, Xing Qi Teo et autres

sg, cn, gb, ch (code pays fourni par la source)

O2‐15‐01: THE DIFFERENTIAL INFLUENCE OF IMMUNE, ENDOCYTOTIC AND LIPID METABOLISM GENES ON AMYLOID DEPOSITION AND NEURODEGENERATION IN ALZHEIMER'S DISEASE

Grazia Daniela Femminella, S. Zakiah A. Talib, Denise H. Harold, Julie H. Williams et autres

With the increasing number of failed treatments in Alzheimer's disease (AD), research has progressed towards the identification of preclinical subjects with increased risk for dementia. Genetic information, such as the presence of the E4 allele of apolipoprotein E (APOE), can help identify …

gb, ie (code pays fourni par la source)

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

Christian Windpassinger, Juliette Piard, Carine Bonnard, Majid Alfadhel et autres

at, fr, sg, sa, de, tr, nl, us, Tunisie (code pays fourni par la source)

The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development

Masanori Saito, Mieradili Mulati, S. Zakiah A. Talib, Philipp Kaldis et autres

Skeletal development is tightly regulated through the processes of chondrocyte proliferation and differentiation. Although the involvement of transcription and growth factors on the regulation of skeletal development has been extensively studied, the role of cell cycle regulatory proteins in this process remains …

jp, sg (code pays fourni par la source)