Samuel López‐Maza

Long‐term mortality after status epilepticus: A 5‐year analysis study

Manuel Alanís-Bernal, Daniel Campos, Laura Abraira, Laura Gómez‐Dabó et autres

OBJECTIVE: To describe 5-year mortality after status epilepticus (SE) and identify factors associated with long-term survival. We also validated the prognostic performance of the Age, Consciousness, Duration (ACD) score and evaluated long-term survival across etiological categories defined by the Lattanzi classification of …

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Freedon study: Real‐life outcomes of cenobamate in different lines of treatment

Vicente Villanueva, José María Serratosa, Alejandro Fernández‐Cabrera, Manuel Toledo et autres

OBJECTIVES: Cenobamate is an antiseizure medication (ASM) with proven effectiveness in individuals with highly refractory epilepsy. This study investigated the effectiveness and tolerability of cenobamate in different treatment lines and a less refractory setting. METHODS: This was a multicenter, retrospective, observational study. …

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Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus

Estevo Santamarina, Laura Abraira, Daniel Campos, Manuel Quintana et autres

OBJECTIVE: This study was undertaken to identify novel blood-based biomarkers associated with the early diagnosis of status epilepticus (SE) by exploring proteomic alterations in plasma extracellular vesicles (EVs). METHODS: We conducted an observational and prospective study in a two-phase design: a discovery …

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The Medical Burden of Drug‐Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real‐World Evidence

Maria Grávalos, Jordi Mayol, Elena Fonseca, Manuel Quintana et autres

OBJECTIVE: Drug-resistant epilepsy (DRE) leads to a range of medical and social consequences, which contribute to a high disease burden. We aimed to describe factors associated with an increased medical burden in DRE. METHODS: We designed a longitudinal prospective study including adult …

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Spanish translation, adaptation, and validation of the Epilepsy Surgery Satisfaction Questionnaire‐19

Elena Fonseca, Alejandro Thomson, Mario Alonso, Óscar Contreras et autres

OBJECTIVE: The effectiveness of surgery in drug-resistant epilepsies is often focused exclusively on seizure control. The Epilepsy Surgery Satisfaction Questionnaire-19 (ESSQ_19), developed in 2020, is a reliable tool for assessing the level of satisfaction of patients undergoing surgery. We aimed to perform …

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Predicting seizure recurrence after status epilepticus: a multicenter exploratory machine learning approach

Francesco Pasini, Manuel Quintana, Marc Rodrigo‐Gisbert, Daniel Campos et autres

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Steps towards seizure freedom with the use of Cenobamate

Manuel Toledo, Laura Abraira, Samuel López‐Maza, B Boy et autres

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Quantitative EEG biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy

Sofía Lallana, Samuel López‐Maza, Gemma Ortega, Elena Fonseca et autres

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A Rare Guillain-Barré Syndrome Variant with Multi-Ganglioside Reactivity: A Case of Severe Cranial Nerve Involvement

Laura Gómez‐Dabó, Arnau Llauradó, Daniel Sánchez‐Tejerina, Victoria González et autres

INTRODUCTION: We present a rare case of acute immune-mediated polyradiculoneuritis, a Guillain-Barré Syndrome (GBS) variant, manifesting as ophthalmoparesis-ataxia, facial diplegia, and acute bulbar palsy, accompanied by a unique autoimmune profile. CLINICAL CASE: A 75-year-old female developed rapidly progressive symptoms, including bilateral non-reactive …

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Trends in antiseizure medication prescription in Idiopathic generalized epilepsy over the last 10 years

Iker Elosua‐Bayés, Laura Abraira, Elena Fonseca, Sofía Lallana et autres

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21210. TENDENCIAS ACTUALES EN EL INICIO Y EFICACIA CLÍNICA DE CENOBAMATO: EXPERIENCIA CLÍNICA

Beatriz Campos Garcia, Samuel López‐Maza, Manuel Quintana, Daniel Campos et autres

Amyloid deposition in adults with drug‐resistant temporal lobe epilepsy

Elena Fonseca, Sofía Lallana, Gemma Ortega, Amanda C. Cano et autres

OBJECTIVE: Pathological amyloid-β (Aβ) accumulation and hyperphosphorylated tau proteins have been described in resected temporal lobe specimens of epilepsy patients. We aimed to determine cerebrospinal fluid (CSF) Aβ1-42 and p181-tau levels and cerebral Aβ deposits on positron emission tomography (Aβ PET) and …

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