Haruka Wada

Acute Heat Exposure Upregulates Zebra Finch Physiology While Avoiding DNA Damage Across Both Sexes

Benjamin D. Haussmann, Margaret R. McGrath, Danica H. Vo, Kevin Pham et autres

A recent increase in the frequency of extreme heat events has urged researchers to examine physiological responses to hot temperatures. Across species, there is variation in whether the sexes respond the same or differently to extreme temperatures. Accordingly, our study investigated the …

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Serological Remission Defined by Anti-Integrin αvβ6 Antibody Predicts Long-Term Clinical Remission of Ulcerative Colitis

Noriaki Oguri, Jun Miyoshi, Nobuki Nemoto, Haruka Kamatsu et autres

Background and Aims: Although management of ulcerative colitis (UC) has advanced with the treat-to-target strategy, biomarkers for relapse remain limited. The anti-integrin αvβ6 (V6) antibody reflects epithelial injury and could be a serological biomarker in UC. This retrospective cohort study evaluated whether …

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Mayo Endoscopic Subscore at Week 24 Is a Predictor of Future Loss of Response to Vedolizumab in Patients with Ulcerative Colitis in Clinical Remission

Daisuke Saito, Minoru Matsuura, Hiromu Morikubo, Noritaka Hibi et autres

Introduction: Vedolizumab (VDZ) is a gut-selective integrin antagonist approved for the treatment of ulcerative colitis. While its efficacy and safety have been demonstrated in clinical trials, real-world data on long-term treatment persistence and factors associated with loss of response are limited. Methods: …

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Altricial and Precocial Development in Birds

Haruka Wada, Sarah E. DuRant, FM Anne McNabb

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Vaginal Lactobacillus crispatus in early pregnancy associates with favorable gestational outcomes in a Japanese maternal-neonatal microbiome cohort

Noriaki Oguri, Chie Kobayashi, Yuri Ozawa, Toshihiko Kimura et autres

The maternal microbiome during pregnancy and the peripartum period plays a critical role in maternal health outcomes and establishing the neonatal gut microbiome, with long-term implications for offspring health. However, a healthy microbiome during these key periods has not been definitively characterized. …

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Developmental Heat Conditioning Alters the Adult Glucocorticoid Response and DNA Damage While Mediating Lifespan Variation in Zebra Finches (Taeniopygia Castanotis)

Alexander J. Hoffman, Natalie R. Gassman, Jack Bazzell, John W. Finger et autres

Developmental stressors may result in adaptive adjustments in physiology, increasing fitness later in life in otherwise damaging environments. Environmental conditions during development can permanently alter the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, which may allow organisms to avoid cellular damage in stressful …

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Maintenance of Physiological and Molecular Processes Through Food Restriction During Offspring Provisioning in the Adult Zebra Finch

Victoria M. Coutts, Hannah E. Butterfield, Natalie R. Gassman, Tonia S. Schwartz et autres

Food restriction is a common environmental stressor, and it can have beneficial effects such as increased longevity when applied to non-reproducing adults. At the molecular level, food restriction can have beneficial effects through increased DNA repair, reduced DNA damage and longer telomeres, …

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Capsule Endoscopy in Inflammatory Bowel Disease: Current Status and Issues in Clinical Practice

Teppei Omori, Haruka Wada, Tatsuya Mitsui, Mari Hayashida et autres

Inflammatory bowel diseases include Crohn's disease (CD) and ulcerative colitis (UC), both of which require endoscopic evaluation of mucosal surfaces. Capsule endoscopy has been used in clinical practice since 2000 as a minimally invasive means of mucosal evaluation. In Japan, there is …

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Mimicking the night shift: Hypothalamic-pituitary-adrenal (HPA) axis regulation, energy homeostasis, and oxidative stress in a model diurnal songbird

Victoria M. Coutts, Alexander J. Hoffman, Haruka Wada

Abstract Everchanging socioeconomic demands, coupled with modern day technological advancements have lifted constraints on human activity patterns, enabling us to take advantage of the 24-h period. However, varying patterns of light at night and sleep/wake may come at the cost of disrupting …

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Physiological Responses Vary with Molecular Damage Outcomes after Recovery from Constant Light

Natalie R. Gassman, Christine R. Lattin, Haruka Wada

The Damage-Fitness model describes how stress is linked to damage and repair pathways that drive health and fitness outcomes across taxa. However, we lack an understanding of how variation in hypothalamic-pituitary-adrenal (HPA) responses (i.e., endocrine flexibility) affects damage, especially after recovery from …

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Whole nest food restriction has persistent physiological effects in developing zebra finches

Victoria M. Coutts, Kevin Pham, Alexander J. Hoffman, Haruka Wada

In a rapidly changing world, food resources are becoming more limited, leading to unpredictable bouts and durations of nutritional stress. Many studies indicate that developmental nutritional stress can permanently alter a suite of physiological, morphological, or behavioral traits, yet the phenotypic effects …

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Characteristic gene expression profile of intestinal mucosa early in life promotes bacterial colonization leading to healthy development of the intestinal environment

Yuu Nishinarita, Jun Miyoshi, Satoshi Kuronuma, Haruka Wada et autres

The gut microbiome early in life plays a crucial role in development of the host and affects health throughout life. The definition of a healthy microbiome early in life has not been established, and the underlying mechanism of how a young host …

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