Amrita Mukherjee

Oral intake of aripiprazole compromises male fertility in Drosophila

Amrita Mukherjee, James D. Hurcomb, Samantha H. Y. Loh, L. Miguel Martins

Antipsychotics have reported off-target effects, but their impact on subcellular organelles and cellular homeostasis in various organ systems is poorly understood. This study explored the off-target effects of aripiprazole on the male reproductive system using Drosophila as a model. Aripiprazole binds nonspecifically …

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Leveraging optimized oligonucleotide-tagged antigen assemblies and single-cell sequencing for multiplexed proteogenomic profiling of human B cell reactivities

Richard Apps, Jessie J. Polanco, Kelsey E. Lowman, Liya Wang et autres

Antigen-specific responses to complex antigens encompass a range of cell states and reactivities to an array of epitopes, reflective of the heterogeneity in immune responses. Single-cell sequencing has created new opportunities when combined with flow cytometry for profiling of immune repertoire and …

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ACLIVIA : a novel rapid testing kit for pesticide residue in green tea leaf

Amrita Mukherjee, Partha Sarathi Chakraborty, Bappaditya Kanrar

Abstract BACKGROUND Ensuring the accurate trace‐level detection of pesticide residues in tea leaves is crucial for maintaining safety, meeting international trade standards and promoting sustainable agricultural practices. A study was undertaken to validate the performance of ACLIVIA, an AI‐powered molecular recognition platform …

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Impact of the COVID-19 pandemic on cancer recurrence rates in patients with ovarian cancer

Amrita Mukherjee, Natalie Ayoub, Lanfang Xu, Kimberly L. Cannavale et autres

The coronavirus diseases 2019 (COVID-19) pandemic was associated with disruption of oncology care and increased utilization of telehealth. However, the impact of the pandemic on cancer outcomes is under-studied. We evaluated the impact of the COVID-19 pandemic on recurrence rates in ovarian …

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Investigating Cisplatin Resistance in Squamous Cervical Cancer: Proteomic Insights into DNA Repair Pathways and Omics-Based Drug Repurposing

Amrita Mukherjee, Avinash Singh, Adrija Ray, Sanjeeva Srivastava

Cisplatin-based chemotherapy is a cornerstone in treating cervical cancer, yet the efficacy is frequently limited by the rapid onset of drug resistance, a major challenge in clinical management. To investigate this, we employed HPV16+ human cervix squamous carcinoma cells, SiHa (CIS/S), and …

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Oral administration of aripiprazole to Drosophila causes intestinal toxicity

James D. Hurcomb, Amrita Mukherjee, Anna E. Lindell, Rebeka Popovic et autres

Aripiprazole is a third-generation antipsychotic medication that was introduced to mitigate the poor tolerability of older antipsychotics. In contrast to the older antipsychotic drugs that act as dopamine receptor antagonists in the brain, aripiprazole functions as a partial agonist. Aripiprazole has been …

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Clinical Remission Rates in Patients With Epithelial Ovarian Cancer Before and After the Onset of the COVID 19 Pandemic in an Integrated Healthcare Delivery System

Amrita Mukherjee, Natalie Ayoub, Lanfang Xu, Kimberly L. Cannavale et autres

Purpose: Evidence on the impact of the coronavirus disease 2019 (COVID-19) pandemic on outcomes in patients with ovarian cancer patients is limited. We compared remission outcomes in patients with ovarian cancer before and during the pandemic. Patients and Methods: This retrospective cohort …

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Establishment of an age-specific reference range for serum total prostate-specific antigen levels among the Indian Bengali male population in a tertiary care hospital

Pradipta Ghosh, Papia Sen, Amrita Mukherjee

Background: Globally, prostate cancer is the most prevalent malignant tumor associated with mortality in men. The most widely used tumor marker for prostate cancer diagnosis is the prostate-specific antigen (PSA). It is already known that racial and geographic factors influence blood PSA …

Replication of the Hermann Grid Illusion by U-Net Deep Learning Architecture Performing Deblurring: A Low-Level Visual Task

Avijit Paul, Amrita Mukherjee, Kuntal Ghosh

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Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation

Johanna Giuranna, Yiran Zheng, M. Brandt, Sigrid Jall et autres

Abstract The C-terminal binding protein 2 ( CTBP2 ) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did a mutation analysis in CTBP2 …

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The great migratory silicone oil

Charudutt Kalamkar, Kalyani Narote, Rohit Rao, Amrita Mukherjee

Silicone oil is used as intraocular tamponade because of its high surface tension in vitreoretinal surgeries.[1] Emulsified silicone oil, if not removed on time, may lead to various complications. We present a collage of images demonstrating the presence of emulsified silicone oil …

Abstract C127: Patterns of mortality risk in insured patients with cancer by race/ethnicity and socioeconomic status in Southern California

Reina Haque, Amrita Mukherjee, Robert Cooper

Abstract Purpose. Several factors including, socioeconomic status (SES), access to screening and healthcare coverage, tumor biology, differences in disease management and care delivery in various healthcare settings, and implicit bias among healthcare providers contribute to mortality disparities in individuals with cancer. Further, …

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