Accès ouvert
2026
article
OpenAlex
María Hernández‐Lorca, MB. Vestergaard, Karen S. Ambrosen, JM. Raghava et autres
Maternal blood levels of polyunsaturated fatty acids (PUFA) during pregnancy have been associated with brain health outcomes in offspring, but causal effects of PUFA on brain metabolism is unexplored. We examined the effect of maternal PUFA supplementation on brain metabolism in children …
dk
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Julie B. Rosenberg, Astrid Sevelsted, Jens Richardt M. Jepsen, Rebecca Vinding et autres
cohort of 700 mother-child pairs, we investigated whether i) maternal DHA + EPA blood concentrations in mid-pregnancy and ii) fish oil supplementation in a randomized trial in late pregnancy influence neurodevelopmental outcomes at age 10. Maternal blood DHA + EPA concentrations were …
dk, au
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Melissa Zandstra, Floortje E Scheepers, Gabriela Lunansky, Silvana Galderisi et autres
BACKGROUND AND HYPOTHESIS: Treatment response in first-episode psychosis varies substantially, yet underlying factors remain poorly understood. Symptom network theory suggests that inter-symptom relationships may influence treatment response. We hypothesized that symptom networks at baseline, as well as dynamic interactions over time, would …
nl, it, dk, gb, us, be
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Karen S. Ambrosen, Tina Dam Kristensen, Louise B. Glenthøj, M. Nordentoft et autres
Resting-state functional magnetic resonance imaging (rs-fMRI) has offered insights into the neural mechanisms underlying psychosis, particularly when associated with clinically relevant features. 102 individuals at ultra-high risk for psychosis (UHR) and 105 matched healthy controls (HC) aged 18-40 underwent clinical and cognitive …
dk, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Anna Feveile, Karen S. Ambrosen, Ketevan Shalikashvili, Jayachandra M. Raghava et autres
AIM: Schizophrenia is associated with subtle brain structural alterations, but separating disease from medication effects is challenging. Antipsychotic dopamine D2 receptor (D2R) antagonism has been associated with striatal volume increases, but effects of partial D2R agonism by newer antipsychotics are largely unexplored. …
dk, ge, nl, au
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Arsime Demjaha, Daniel Ståhl, Celso Arango, Birte Glenthøj et autres
BACKGROUND: The negative symptoms of psychosis are heterogeneous, which complicates efforts to understand their pathophysiology and develop effective treatments. Factor analytic studies of the Positive and Negative Syndrome Scale (PANSS) have reported two factorial negative symptom models, expressive deficit and social amotivation, …
gb, es, dk, us, nl
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
B. King, Kirsten Borup Bojesen, Charlotte Crisp, Andrea de Bartolomeis et autres
Abstract Understanding the mechanisms underlying the response to antipsychotic medications is critical for refining targets for new interventions and predicting clinical outcomes. This study presents a mega-analysis of individual participant data (N = 1,189) from 18 ¹H-MRS datasets to examine differences in …
gb, dk, it, nl, mx, ca, au, hu, cn, jp, us, tw, nz
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shuqing Si, Cheryl R. Z. See, Emily Hedges, Stefania Tognin et autres
BACKGROUND: Brain volume alterations in those at clinical high risk (CHR) of psychosis have been reported in many studies. However, the association between these alterations and the longitudinal trajectory of changes in symptoms and functioning remains unexplored. STUDY DESIGN: T1-weighted magnetic resonance …
gb, nl, au, ch, br, es, us, fr, dk, de, at
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Fabian M. Mager, Tina Dam Kristensen, Edwin van Dellen, Livia Dominicus et autres
Abstract Aberrant microstate features of resting-state electroencephalography (rsEEG) have been proposed as potential endophenotypic markers for schizophrenia. However, longitudinal investigations across the psychosis continuum remain limited, particularly regarding treatment effects and illness-related alterations over time. We examined 47 antipsychotic-naïve, first-episode patients with …
dk, be, nl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Siwei Liu, Ingrid Agartz, Paul Allen, G. Paul Amminger et autres
Brain network architecture is anticipated to influence future grey matter loss in individuals at Clinical High Risk (CHR) for psychosis. However, existing studies on grey matter structural network properties in CHR are scarce and constrained by small sample sizes. Here, we examined …
sg, no, se, fr, gb, au, us, es, ch, de, cn, kr, nl, mx, dk, ca, it, jp, ru
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Margot I. E. Slot, Hendrika H. van Hell, Inge Winter-van Rossum, George Gifford et autres
Background: We examined the course of cognitive performance in first-episode psychosis (FEP) compared to healthy controls (HC), and whether this varied across subgroups of patients defined by premorbid functioning (PMF) trajectories, using a clustering approach. Methods: Data were collected in 302 FEP …
nl, gb, us, es, dk, ie, de, au, it, il, at, ch, kr, jp
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Kirsten Borup Bojesen, Cecilie K. Lemvigh, Anne Sigvard, Mark Bitsch Vestergaard et autres
Although emerging evidence supports glutamatergic dysfunction in schizophrenia, clinical trials with glutamatergic compounds have overall been negative. This may be due to changes in glutamate levels during the course of illness. To address this, we measured glutamate levels in dorsal anterior cingulate …
dk
(code pays fourni par la source)