Anne Sigvard

Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients with psychosis are related to clinical symptoms and cognition

Kirsten Borup Bojesen, Cecilie K. Lemvigh, Anne Sigvard, Mark Bitsch Vestergaard et autres

Although emerging evidence supports glutamatergic dysfunction in schizophrenia, clinical trials with glutamatergic compounds have overall been negative. This may be due to changes in glutamate levels during the course of illness. To address this, we measured glutamate levels in dorsal anterior cingulate …

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Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response

Kirsten Borup Bojesen, Karen S. Ambrosen, Anne Sigvard, Mette Ødegaard Nielsen et autres

Abstract Preclinical evidence points to disturbances in neural networks in psychosis involving interrelations between dopaminergic-, GABAergic- and glutamatergic neurotransmitter systems. In support, we have previously shown that aberrant interrelations between these neurotransmitters, in contrast to individual transmitter systems, can separate antipsychotic-naïve first-episode …

dk, ca, jp (code pays fourni par la source)

Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients with psychosis are related to clinical symptoms and cognition

Kirsten Borup Bojesen, Cecilie K. Lemvigh, Anne Sigvard, Mark Bitsch Vestergaard et autres

Abstract Although emerging evidence supports glutamatergic dysfunction in schizophrenia, clinical trials with glutamatergic compounds have overall been negative. This may be due to changes in glutamate levels during the course of illness. To address this, we measured glutamate levels in dorsal anterior …

Interrelations Between Dopaminergic-, GABAergic- and Glutamatergic Neurotransmitters in Antipsychotic-Naïve Psychosis Patients and the Association to Initial Treatment Response

Kirsten Borup Bojesen, Karen S. Ambrosen, Anne Sigvard, Mette Ødegaard Nielsen et autres

Abstract Preclinical evidence points to disturbances in neural networks in psychosis involving interrelations between dopaminergic-, GABAergic- and glutamatergic neurotransmitter systems. In support, we have previously shown that aberrant interrelations between these neurotransmitters, in contrast to individual transmitter systems, can separate antipsychotic-naïve first-episode …

dk, jp (code pays fourni par la source)

Glycocalyx shedding patterns identifies antipsychotic-naïve patients with first-episode psychosis

Helle G. Andersen, Brian DellaValle, Hjalte Bøgehave, Phillip Bredahl Mogensen et autres

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The Trajectory of Prefrontal GABA Levels in Initially Antipsychotic-Naïve Patients With Psychosis During 2 Years of Treatment and Associations With Striatal Cerebral Blood Flow and Outcome

Kirsten Borup Bojesen, Egill Rostrup, Anne Sigvard, Mark E. Mikkelsen et autres

BACKGROUND: GABAergic (gamma-aminobutyric acidergic) function in the prefrontal cortex seems dysfunctional in patients with first-episode psychosis, but the impact of longer-term treatment and relationship to clinical outcomes and striatal activity are unknown. METHODS: A longitudinal study of 39 antipsychotic-naïve and benzodiazepine-free patients …

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Clinical response to treatment with a partial dopamine agonist is related to changes in reward processing

Karen Tangmose, Egill Rostrup, Kirsten Borup Bojesen, Anne Sigvard et autres

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Cerebral blood flow in striatum is increased by partial dopamine agonism in initially antipsychotic-naïve patients with psychosis

Kirsten Borup Bojesen, Birte Glenthøj, Anne Sigvard, Karen Tangmose et autres

Abstract Background Resting cerebral blood flow (rCBF) in striatum and thalamus is increased in medicated patients with psychosis, but whether this is caused by treatment or illness pathology is unclear. Specifically, effects of partial dopamine agonism, sex, and clinical correlates on rCBF …

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Dopamine Synthesis Capacity and GABA and Glutamate Levels Separate Antipsychotic-Naïve Patients With First-Episode Psychosis From Healthy Control Subjects in a Multimodal Prediction Model

Anne Sigvard, Kirsten Borup Bojesen, Karen S. Ambrosen, Mette Ødegaard Nielsen et autres

Disturbances in presynaptic dopamine activity and levels of gamma-aminobutyric acid (GABA) and glutamate plus glutamine (Glx) collectively may have a role in the pathophysiology of psychosis, although separately they are poor diagnostic markers. We tested whether these neurotransmitters in combination improve the …

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Dopaminergic Activity in Antipsychotic-Naïve Patients Assessed With Positron Emission Tomography Before and After Partial Dopamine D2 Receptor Agonist Treatment: Association With Psychotic Symptoms and Treatment Response

Anne Sigvard, Mette Ødegaard Nielsen, Albert Gjedde, Kirsten Borup Bojesen et autres

Background Dopamine activity has been associated with the response to antipsychotic treatment. Our study used a four-parameter model to test the association between the striatal decarboxylation rate of 18 F-DOPA to 18 F-dopamine (k 3 ) and the effect of treatment on …

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Reward disturbances in antipsychotic-naïve patients with first-episode psychosis and their association to glutamate levels

Karen Tangmose, Egill Rostrup, Kirsten Borup Bojesen, Anne Sigvard et autres

Abstract Background Aberrant anticipation of motivational salient events and processing of outcome evaluation in striatal and prefrontal regions have been suggested to underlie psychosis. Altered glutamate levels have likewise been linked to schizophrenia. Glutamatergic abnormalities may affect the processing of motivational salience …

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Associations Between Cognitive Function and Levels of Glutamatergic Metabolites and Gamma-Aminobutyric Acid in Antipsychotic-Naïve Patients With Schizophrenia or Psychosis

Kirsten Borup Bojesen, Brian V. Broberg, Birgitte Fagerlund, Kasper Jessen et autres

BACKGROUND: Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large …

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