Ben Goldacre

The effect of herpes zoster vaccines on incident dementia in England: Protocol for an OpenSAFELY regression discontinuity study

Venexia Walker, Andrea L. Schaffer, William Hulme, Christopher Wood et autres

Abstract The English national shingles vaccination programme was officially launched on 1 September 2013 using the live attenuated herpes zoster vaccine Zostavax and updated on 1 September 2023 to replace Zostavax with the two-dose, non-live, recombinant subunit herpes zoster vaccine Shingrix. A …

gb, us (code pays fourni par la source)

Variation in uptake and dose reduction of CDK4/6 inhibitors for the treatment of breast cancer in England, 2019–2024: a descriptive observational study using OpenPrescribing Hospitals

Louis Fisher, Calum Polwart, Christopher Wood, Ben Goldacre et autres

Abstract Background The number of novel cancer therapies approved for use in England by the National Institute for Health and Care Excellence is increasing. Monitoring the adoption of new therapies is important to assess equity of access and evaluate real-world prescribing practices. …

gb (code pays fourni par la source)

Trends and variations in Lithium usage across care settings in England between 2015-2024

Hayley Schiffer, Louis Fisher, Helen J Curtis, Christopher Wood et autres

Abstract Lithium has been the gold standard for the treatment and prevention of relapse in bipolar disorder for over 60 years. Guidance from the National Institute for Health and Clinical Excellence states explicitly to “offer lithium as a first-line, long-term pharmacological treatment …

gb (code pays fourni par la source)

Pregnancy-Related Clinical Codes in Unlikely Populations in Primary Care

Helen J Curtis, Peter Inglesby, Ben Goldacre, Rose Higgins et autres

Unlabelled: We discovered that the official list of clinical codes for pregnancy during the COVID-19 pandemic identified some unlikely pregnancies (for example, in older men), principally due to a code describing a specific fetal position ("knee presentation"), which notably lacks "fetal" in …

gb (code pays fourni par la source)

Classifying and Differentiating Individuals with Respiratory Syncytial Virus, Influenza, and COVID-19 Cases in OpenSAFELY Between 2016 and 2024

Em Prestige, Charlotte Warren‐Gash, Jennifer K Quint, Dave Evans et autres

Abstract Electronic health records (EHRs) are a rich source of data which can be used to analyse health outcomes using computable phenotypes. With the approval of NHS England we used the OpenSAFELY secure analytics platform to design and assess phenotypes to classify …

gb (code pays fourni par la source)

Occurrence and persistence of symptoms, diagnoses and prescriptions after community-diagnosed COVID-19: a matched cohort study using the OpenSAFELY platform

Kevin Wing, Caroline E Morton, Viyaasan Mahalingasivam, Ruth Costello et autres

BACKGROUND: We aimed to explore the occurrence and persistence of symptoms, diagnoses and prescribing after COVID-19 among populations from earlier (wave 2) and later (wave 4) in the pandemic. METHODS: With the approval of NHS England, we analysed data from English primary …

gb, tw, kh (code pays fourni par la source)

Long-term Respiratory Outcomes of COVID-19 in England by Vaccination Status

Mengxuan Zou, Venexia Walker, Harry T. Mason, Emily Eyles et autres

gb, ca, in, us (code pays fourni par la source)

Trends and variation in the use of andexanet alfa for the reversal of direct oral anticoagulants in NHS trusts in England

Louis Fisher, Richard J. Buka, Rosalind Byrne, Stephen Black et autres

AIMS: Andexanet alfa was recommended by the National Institute for Health and Clinical Excellence (NICE) as an option in the management of life-threatening gastrointestinal bleeding in patients taking apixaban or rivaroxaban in May 2021. A recent UK-wide survey of local hospital protocols …

gb (code pays fourni par la source)

Hospitalisation and mortality impact of shielding during 2020 in England: a transmission modelling evaluation using the OpenSAFELY platform

Edwin van Leeuwen, Alasdair D Henderson, Nicholas G. Davies, Christopher I Jarvis et autres

Abstract Background During the early phase of the Covid-19 pandemic in England, people with pre-existing conditions that put them at severe clinical risk if infected were advised to drastically reduce face-to-face contacts in a policy known as “shielding”. The impact of this …

gb (code pays fourni par la source)

Pregnancy-related clinical codes in unlikely populations in primary care (Preprint)

Helen J Curtis, Peter Inglesby, Ben Goldacre, Rose Higgins et autres

UNSTRUCTURED We discovered that the official national UK SNOMED CT codelist for identifying pregnant people during the COVID-19 pandemic identified pregnancy in people who were very unlikely to be pregnant (for example, elderly men). Analysing usage patterns of the individual codes identified …

Unlock dental data to improve public health

Kristina Wanyonyi, Ben Goldacre, Mary Dixon‐Woods

The NHS’s plan for recovering dental services will require a coordinated, comprehensive data ecosystem, write Kristina Wanyonyi-Kay, Ben Goldacre, and Mary Dixon-Woods

gb, qa, in (code pays fourni par la source)

Venous thromboembolism risk following surgery during the COVID ‐19 pandemic

A. Jackson, David J. Humes, Amir Mehrkar, Seb Bacon et autres

INTRODUCTION: SARS-CoV-2 infection is associated with an increased risk of venous thromboembolism. Data are lacking on how this risk altered during the COVID-19 pandemic and following vaccination. We aimed to evaluate the 90-day risk of postoperative venous thromboembolism during the pandemic. METHODS: …

gb (code pays fourni par la source)