Louis Fisher

Variation in uptake and dose reduction of CDK4/6 inhibitors for the treatment of breast cancer in England, 2019–2024: a descriptive observational study using OpenPrescribing Hospitals

Louis Fisher, Calum Polwart, Christopher Wood, Ben M. Goldacre et autres

Abstract Background The number of novel cancer therapies approved for use in England by the National Institute for Health and Care Excellence is increasing. Monitoring the adoption of new therapies is important to assess equity of access and evaluate real-world prescribing practices. …

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Trends and variations in Lithium usage across care settings in England between 2015-2024

Hayley Schiffer, Louis Fisher, Helen Jane Curtis, Christopher Wood et autres

Abstract Lithium has been the gold standard for the treatment and prevention of relapse in bipolar disorder for over 60 years. Guidance from the National Institute for Health and Clinical Excellence states explicitly to “offer lithium as a first-line, long-term pharmacological treatment …

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Recording of Pharmacy First consultations in general practice records in England: an observational study of the service's first year using OpenSAFELY

Viveck Kingsley, Milan Wiedemann, Christopher Wood, Helen Jane Curtis et autres

BACKGROUND: Pharmacy First, a national community pharmacy service, launched in January 2024 to improve access to primary care for patients with minor conditions facing backlogs caused by the COVID-19 pandemic. Pharmacies are required to share details about their consultations with general practices. …

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Identifying the NHS Trusts within Cancer Alliances

Louis Fisher, Victoria Speed

A description of what Cancer Alliances are, how the NHS trusts they partner with can be identified, and why this is useful when analysing secondary care medicines usage data.

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Understanding NHS Trust Types

Louis Fisher, Victoria Speed, Christopher Wood, Arina Tamborska

NHS trusts in England vary in size, degree of specialisation and the severity of illnesses that they care for. Some trusts have emergency departments and offer acute care, while others focus on longer-stay rehabilitation, mental health or community-based follow-up care. Some provide …

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Long-term Respiratory Outcomes of COVID-19 in England by Vaccination Status

Mengxuan Zou, Venexia M. Walker, Harry T. Mason, Emily Eyles et autres

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Trends and variation in the use of andexanet alfa for the reversal of direct oral anticoagulants in NHS trusts in England

Louis Fisher, Richard John Buka, Rosalind Byrne, Stephen James Black et autres

AIMS: Andexanet alfa was recommended by the National Institute for Health and Clinical Excellence (NICE) as an option in the management of life-threatening gastrointestinal bleeding in patients taking apixaban or rivaroxaban in May 2021. A recent UK-wide survey of local hospital protocols …

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The impact of COVID-19 on gastrointestinal diseases in vaccinated and unvaccinated individuals: a population-based cohort study in England

Marwa Al Arab, Genevieve Isabelle Cezard, Colin John Crooks, Yinghui Wei et autres

ABSTRACT Background COVID-19 is associated with higher rates of gastrointestinal diseases, though the duration of this effect, and the role of vaccination and COVID-19 severity remain uncertain. Objective To investigate the relationship between COVID-19 and gastrointestinal diseases, by vaccination status in hospitalised …

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OpenPrescribing Hospitals: An open access analytics platform for hospital medicines use in England

Louis Fisher, Christopher Wood, Andrew D Brown, Richard S. Croker et autres

Abstract Primary care prescribing data for general practices in England has been openly published since 2011. The OpenPrescribing platform provides an open, transparent and easy-to-use interface to this data. OpenPrescribing is widely used by NHS professionals, the public and by industry and …

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Measuring anticoagulant use in secondary care using OpenPrescribing Hospitals: Part 1

Victoria Speed, Louis Fisher, Christopher Wood

A description of how OpenPrescribing Hospitals can be used to look at low molecular weight heparin use in hospital trusts in England.

Measuring anticoagulant use in secondary care using OpenPrescribing Hospitals: Part 3

Victoria Speed, Louis Fisher, Christopher Wood

A description of how OpenPrescribing Hospitals can be used to look at vitamin k antagonists use in hospital trusts in England.

Measuring anticoagulant use in secondary care using OpenPrescribing Hospitals: Part 2

Victoria Speed, Louis Fisher, Christopher Wood

A description of how OpenPrescribing Hospitals can be used to look at direct oral anticoagulants use in hospital trusts in England.