Accès ouvert
2025
article
OpenAlex
M. L. Parker, Samar Mahmoud, Bailey C. Montefiore, Mario Öeren et autres
We explore a "best-of-both" approach to modeling molecular properties by combining learned molecular descriptors from a graph neural network (GNN) with general-purpose descriptors and a mixed ensemble of machine learning (ML) models. We introduce a MetaModel framework to aggregate predictions from a …
gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M. J. Koolen et autres
A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. Over the last decade, compounds identified in phenotypic high throughput …
nl, ch, gb, Kenya
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M. J. Koolen et autres
Abstract A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. Over the last decade, compounds identified in phenotypic high …
nl, ch, gb, Kenya
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Marco Salamina, Bailey C. Montefiore, Mengxi Liu, D.J. Wood et autres
ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regulatory subunit CKS1. We further show that a direct interaction between …
gb, us, fr, sa
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Marco Salamina, Bailey C. Montefiore, Mengxi Liu, D.J. Wood et autres
Abstract The SCF SKP2 ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regulatory subunit CKS1. We further show that …
gb, us, fr, sa
(code pays fourni par la source)