Jennifer Orlowski

CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis

Birte Dyck, Andrea Witowski, Thilo Bracht, Malte Bayer et autres

Background: Sepsis is characterized by a dysregulated host response to infection, leading to concurrent hyperinflammation and immunosuppression, including profound alterations in T lymphocyte homeostasis. The chemokine CXCL10, an interferon-γ-inducible mediator of T cell trafficking, has been implicated in immune activation and tissue …

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Association of AQP5 gene variants and mRNA expression with caries severity in a dental practice cohort: a randomized trial

Janusch Bitter, Daria Pakosch-Nowak, Michael Adamzik, Dominik Ziehe et autres

Aquaporin 5 (AQP5) is crucial for salivary secretion, composition and enamel mineralization. Genetic variations in AQP5 may influence susceptibility to dental diseases such as caries. This study investigated the association between AQP5 single nucleotide polymorphisms (SNPs), AQP5 mRNA expression, and caries severity …

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AQP3 as a potential biomarker for caries

Markus Baumann, Daria Pakosch-Nowak, Dominik Ziehe, Bjoern Koos et autres

BACKGROUND AND OBJECTIVES: Dental caries and periodontitis are among the most common dental diseases worldwide and represent a major public health concern due to their high prevalence and age-dependent occurrence. Identifying molecular factors in saliva involved in their development may help improve …

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Salivary AQP9 mRNA expression is associated with caries and periodontitis prevalence

Markus Baumann, Katharina Rump, Dominik Ziehe, Bjoern Koos et autres

Dental caries and periodontitis are the most frequently diagnosed dental diseases worldwide. Their occurrence is age-dependent and, due to their widespread prevalence, they represent a major public health challenge. Further research is essential to identify factors that can be used to develop …

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Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort

Christoph Sombetzki, Lars Palmowski, Dominik Ziehe, Hartmuth Nowak et autres

The glucocorticoid receptor (GR), particularly its isoforms GRα and GRβ, plays a crucial role in modulating inflammatory responses. The rs6198 single nucleotide polymorphism (SNP) in the NR3C1 gene, which encodes GR, has been associated with adverse outcomes in various diseases due to …

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Aquaporin mRNA in Human Saliva

Katharina Rump, Daria Pakosch-Nowak, Andrea Witowski, Björn Koos et autres

BACKGROUND: Aquaporins (AQPs) are integral membrane proteins that facilitate water transport across biological membranes. While their role is well-characterized in various tissues, their function in the oral cavity remains poorly understood. Saliva is an easily accessible, non-invasive biofluid that contains stable extracellular …

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Activation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: a real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort

Andrea Witowski, Lars Palmowski, Tim Rahmel, Hartmuth Nowak et autres

PURPOSE: There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses of COVID-19. The effect of this cascade in COVID-19 sepsis is still undetermined. Therefore, we tested the hypothesis that activity of …

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AQP3 and AQP9—Contrary Players in Sepsis?

Patrick Thon, Tim Rahmel, Dominik Ziehe, Lars Palmowski et autres

Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ-organ interaction networks. Potential drug targets can depict aquaporins, as they are involved in immunological processes. In immune cells, AQP3 and AQP9 …

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Methazolamide Reduces the AQP5 mRNA Expression and Immune Cell Migration—A New Potential Drug in Sepsis Therapy?

Katharina Rump, Björn Koos, Dominik Ziehe, Patrick Thon et autres

Sepsis is a life-threatening condition caused by the dysregulated host response to infection. Novel therapeutic options are urgently needed and aquaporin inhibitors could suffice as aquaporin 5 (Aqp5) knockdown provided enhanced sepsis survival in a murine sepsis model. Potential AQP5 inhibitors provide …

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The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

Patrick Thon, Katharina Rump, Annika Knorr, Birte Dyck et autres

Clinical success of Toll-Like receptor-4 (TLR-4) antagonists in sepsis therapy has thus far been lacking. As inhibition of a receptor can only be useful if the receptor is active, stratification of patients with active TLR-4 would be desirable. Our aim was to …

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Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?

Katharina Rump, Caroline Holtkamp, Lars Bergmann, Hartmuth Nowak et autres

Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to interfere with its proper metabolism, which can be triggered by epigenetic modifications. …

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Efficacy of Probiotics and Nutrients in Functional Gastrointestinal Disorders: A Preliminary Clinical Trial

Linda S. Kim, Lisa Hilli, Jennifer Orlowski, Jami L. Kupperman et autres

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