Claudia Lennicke

Enhancing autophagy by redox regulation extends lifespan in Drosophila

Claudia Lennicke, Ivana Bjedov, Sebastian Grönke, Katja E. Menger et autres

Abstract Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H2O2 in vivo, we established a redox-shifted model by manipulating levels of the H2O2-degrading enzyme catalase in Drosophila. Here we …

gb, de (code pays fourni par la source)

OxiFly: Sex-specific redox proteomic networks in ageing drosophila

Claudia Lennicke, Jonathan J. Petrocelli, Nils Burger, George Berkeley Young et autres

gb, us (code pays fourni par la source)

Heterocyclic and Alkyne Terpenoids by Terpene Synthase‐Mediated Biotransformation of Non‐Natural Prenyl Diphosphates: Access to New Fragrances and Probes

Benjamin Weigel, Jeanette Ludwig, Roman Weber, Steve Ludwig et autres

Two terpene cyclases were used as biocatalytic tool, namely, limonene synthase from Cannabis sativa (CLS) and 5-epi-aristolochene synthase (TEAS) from Nicotiana tabacum. They showed significant substrate flexibility towards non-natural prenyl diphosphates to form novel terpenoids, including core oxa- and thia-heterocycles and alkyne-modified …

de (code pays fourni par la source)

Sugar-Induced obesity and insulin resistance are uncoupled from shortened survival in drosophila

Van Dam E, van Leeuwen LAG, Dos Santos E, L. C. Best et autres

In brief: High-sugar diets cause thirst, obesity and metabolic dysregulation, leading to insulin resistance, the MetS, T2DM and shortened lifespan. This study shows that high sugar diets induce dehydration in adult Drosophila. Water supplementation fully rescued the shortened lifespan, but not the …

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Claudia Lennicke, Helena M. Cochemé

gb (code pays fourni par la source)

Redox regulation of the insulin signalling pathway

Claudia Lennicke, Helena M. Cochemé

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which mediates fundamental cellular responses. Oxidants, in particular H2O2, have been recognised as insulin-mimetics. Treatment of cells …

gb (code pays fourni par la source)

Sugar-induced dysregulation of purine metabolism impacts lifespan

Claudia Lennicke, Eliano dos Santos, Helena M. Cochemé

gb (code pays fourni par la source)

Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

Paul Jänicke, Claudia Lennicke, Annette Meister, Barbara Seliger et autres

de (code pays fourni par la source)

Redox signalling and ageing: insights from Drosophila

Claudia Lennicke, Helena M. Cochemé

Ageing and age-related diseases are major challenges for the social, economic and healthcare systems of our society. Amongst many theories, reactive oxygen species (ROS) have been implicated as a driver of the ageing process. As by-products of aerobic metabolism, ROS are able …

gb (code pays fourni par la source)

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

Esther van Dam, Lucie A.G. van Leeuwen, Eliano dos Santos, Joel James et autres

High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to disentangle. Here, we show that high sugar …

gb, de (code pays fourni par la source)

Enhancing autophagy by redox regulation extends lifespan in Drosophila

Claudia Lennicke, Ivana Bjedov, Sebastian Grönke, Katja E. Menger et autres

Abstract Dysregulation of redox homeostasis has been implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H 2 O 2 in vivo , we established a redox-shifted model by manipulating levels of the H 2 …

gb, de (code pays fourni par la source)

Modulation of the cellular redox state by distinct selenocompounds and their effects on cell signaling processes

Claudia Lennicke

Das essentielle Spurenelement Selen (Se) ist als Bestandteil von Selenoproteinen an verschiedenen physiologischen Prozessen, wie beispielsweise der Aufrechterhaltung der zellulären Redox-Homöostase, beteiligt. In der Literatur wird die Rolle von Se in der Tumorprävention als auch bei metabolischen Erkrankungen kontrovers diskutiert. Die in …