Marielle Odin

P19-26 Moving towards a framework for in vitro risk assessment and determination of human relevance of rodent liver-mediated thyroid toxicity

H. Tinwell, L. Beuret, Bagirath Gangadharan, J. Kuehnlenz et autres

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Proceedings of the 2020 Classic Examples in Toxicologic Pathology XXVII

Thomas Nolte, Wolfgang Baumgärtner, Florian Colbatzky, Anja Knippel et autres

The histopathology slide seminar "Classic Examples in Toxicologic Pathology XXVII" was held on February 21 and 22, 2020, at the Department of Pathology at the University of Veterinary Medicine in Hannover, Germany, with joint organization by the European Society of Toxicologic Pathology. …

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Severe treatment-refractory T-cell-mediated immune skin toxicities observed with obinutuzumab/rituximab-atezo-pola in two patients with follicular lymphoma

Max S. Topp, Johannes Duell, Ana Maria Abajo Guijarro, Marielle Odin et autres

Severe treatment-refractory T-cell-mediated immune skin toxicities observed with obinutuzumab/ rituximab

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Publisher Correction: A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy

Fabio Villani, Riccardo Civico, Stefano Pucci, Luca Pizzimenti et autres

In the original version of the Data Descriptor the surname of author Anne Socquet was misspelled. This has now been corrected in the HTML and PDF versions of the Data Descriptor. Some authors were also not appropriately associated with their affiliations in …

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GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

Sabine Sewing, Marcel Gubler, Régine Gérard, Blandine Avignon et autres

Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift their biodistribution …

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Meeting Report: Tissue-based Image Analysis

Chandrassegar Saravanan, Vanessa Schumacher, Danielle L. Brown, Robert W. Dunstan et autres

Quantitative image analysis (IA) is a rapidly evolving area of digital pathology. Although not a new concept, the quantification of histological features on photomicrographs used to be cumbersome, resource-intensive, and limited to specialists and specialized laboratories. Recent technological advances like highly efficient …

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Scientific and Regulatory Policy Committee (SRPC) Review*

Charles E. Wood, Renee Hukkanen, Radhakrishna Sura, David Jacobson‐Kram et autres

Increased cell proliferation is a central key event in the mode of action for many non-genotoxic carcinogens, and quantitative cell proliferation data play an important role in the cancer risk assessment of many pharmaceutical and environmental compounds. Currently, there is limited unified …

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STP Position Paper

Kristen J. Nikula, Jeffrey McCartney, Timothy J. McGovern, Glen K. Miller et autres

The Scientific and Regulatory Policy Committee of the Society of Toxicologic Pathology (STP) appointed a working group to address risk assessment for increases in alveolar macrophages following inhalation of pharmaceutical materials. This position paper provides recommendations for inhalation study-specific terminology and interpretation …

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General principles and methods for routine automated microRNA in situ hybridization and double labeling with immunohistochemistry

U. Singh, Natalie Keirstead, Alex Wolujczyk, Marielle Odin et autres

MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression by binding to complementary sequences on target messenger RNA transcripts. Changes in the expression levels of specific miRNAs have been associated with a variety of disease conditions. We developed a reliable and …

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Abstract 2319: Dual inhibition of Ang-2 and VEGF via a novel human bispecific bivalent IgG1 CrossMAb shows potent anti-angiogenic, antitumoral, and antimetastatic efficacy and leads to a reduced side effect profile compared to single therapies

Markus Thomas, Yvonne Kienast, Werner Scheuer, Erica Lorenzon et autres

Abstract VEGF-A blockade has been extensively clinically validated as a treatment for human cancers. Angiopoietin-2 (Ang-2) expression has been shown to function as a key regulator of blood vessel remodeling, tumor angiogenesis, and metastasis. In tumors, Ang-2 is up-regulated and associated with …

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Recommendations for Pathology Peer Review

Daniel Morton, Rani S. Sellers, Erio Barale-Thomas, Brad Bolon et autres

Pathology peer review verifies and improves the accuracy and quality of pathology diagnoses and interpretations. Pathology peer review is recommended when important risk assessment or business decisions are based on nonclinical studies. For pathology peer review conducted before study completion, the peer-review …

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Letter to the Editor

Brian R. Berridge, Linda A. Chatman, Marielle Odin, A. Eric Schultze et autres

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