Milena Fronza Broering

Water- and alkali-extracted wheat bran polysaccharides differentially affect antiproliferative and cell death responses in HCT116 and HT29 cells

Candela Paesani, Milena Fronza Broering, Gabriela T. Peréz, João Paulo Fabi

Wheat bran is a major by-product of cereal processing and a rich source of dietary polysaccharides with potential health-promoting properties. However, the biological activity of soluble polysaccharide fractions can be strongly influenced by extraction conditions and the resulting physicochemical characteristics. Soluble polysaccharide …

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Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development

Luana Filippi Xavier, Ranko Gaćeša, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering et autres

Background Inflammatory Bowel Diseases (IBDs) are characterized by intestinal dysbiosis and immune dysregulation. Annexin A1 (AnxA1) promotes epithelial repair and inhibits immune responses during IBD. However, AnxA1’s impact on gut microbiota during IBD remains unclear. Here, we experimentally investigated the microbiota profile …

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Discovery and Early Optimization of 1 H -Indole-2-carboxamides with Anti- Trypanosoma cruzi Activity

Ramon Guerra de Oliveira, Luiza R. Cruz, Marco A. Dessoy, Paul J. Koovits et autres

High Resolution Image Download MS PowerPoint Slide Chagas disease (CD), caused by the flagellate protozoan Trypanosoma cruzi, is a neglected tropical disease endemic in 21 countries. The only two antiparasitic drugs approved for its treatment, benznidazole and nifurtimox, have significant drawbacks. We …

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Novas formulações de Anexina A1 como estratégia terapêutica para a colite experimental

Milena Fronza Broering

A Anexina A1 (AnxA1) é uma proteína de 37 kDa que controla o desenvolvimento da reação inflamatória inata, e favorece a eferocitose e o reparo tecidual. Em doenças inflamatórias intestinais (DIIs), tanto a AnxA1 endógena, como a sintética e o peptídeo sintético …

Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases

Milena Fronza Broering, Pedro Oseliero Filho, Pâmela Pacassa Borges, Luís Henrique Mendes da Silva et autres

Introduction: Inflammatory bowel diseases (IBDs) disrupt the intestinal epithelium, leading to severe chronic inflammation. Current therapies cause adverse effects and are expensive, invasive, and ineffective for most patients. Annexin A1 (AnxA1) is a pivotal endogenous anti-inflammatory and tissue repair protein in IBD. …

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Development of an Inflamed High Throughput Stem-cell-based Gut Epithelium Model to Assess the Impact of Annexin A1

Milena Fronza Broering, Stefania Tocci, Noah T. Sout, Chris P.M. Reutelingsperger et autres

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Effect of nanocapsules containing docosahexaenoic acid in mice with chronic inflammation

Matheus de Castro Leão, I. Piazza, Sarah Jorge Caria, Milena Fronza Broering et autres

Omega 3 fatty acids, such as docosahexaenoic acid (DHA) have been widely consumed as supplements to control chronic inflammation. Nanocapsules containing DHA (MLNC-DHA-a1) were developed and showed excellent stability. Thus, our objective was to evaluate the effect of MLNC-DHA-a1 nanocapsules on biomarkers …

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Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis

Silvana Sandri, Cristina Bichels Hebeda, Milena Fronza Broering, Marina de Paula Silva et autres

Annexin A1 (AnxA1) is highly secreted by neutrophils and binds to formyl peptide receptors (FPRs) to trigger anti-inflammatory effects and efferocytosis. AnxA1 is also expressed in the tumor microenvironment, being mainly attributed to cancer cells. As recruited neutrophils are player cells at …

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Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis

Milena Fronza Broering, Matheus de Castro Leão, Gustavo Henrique Oliveira da Rocha, Pablo Rhasan dos Santos Scharf et autres

and AnxA1 was added to form MLNC-AnxA1. LNC, MLNC and MLNC-AnxA1 presented average size of 129, 152 and 163 nm, respectively, and similar polydispersity indexes (0.xx); incorporation of chitosan inverted the negative potential zeta; the coordination efficiency of AnxA1 was 92.22 %, …

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Development of Annexin A1-Surface-Functionalized Metal-Complex Multi-Wall Lipid Core Nanocapsules and Effectiveness on Experimental Colitis

Sandra H.P. Farsky, Milena Fronza Broering, Matheus Leão, Gustavo Henrique Oliveira da Rocha et autres

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Supplementation with Moringa oleifera leaves flour prevents fructose-based metabolic disorders in young rats

Izabel Carolina Bousfield Terranova, Izabelle Coelho Souza, Isadora Simas Ribeiro, Milena Fronza Broering et autres

Moringa oleifera leaves flour is amply used to treat metabolic conditions. The aim was to assess the M. oleifera flour (MOF) on metabolic changes induced by fructose. Phenolic compounds were determined by LC-ESI-MS/MS. Wistar rats were distributed in groups: 1) Control (normal-chow …

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Sambucus nigra: A traditional medicine effective in reducing inflammation in mice

José Roberto Santin, Larissa Benvenutti, Milena Fronza Broering, Roberta Nunes et autres

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