Alma Dhawahir

Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice

Elena Zamorano-Domínguez, Lucía Morales-Cacho, Rafael Barrero, Silvia Jiménez-Parrado et autres

The KRAS oncogene has been associated with many types of cancer, including pancreatic, lung, and colorectal. For decades, its gene products were thought to be undruggable. However, during the last decade, a large battery of KRAS inhibitors selective against specific mutations (KRAS …

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Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

Matthias Drosten, Alma Dhawahir, Eleanor Y. M. Sum, Jelena Urosevic et autres

es (code pays fourni par la source)

Using cells devoid of RAS proteins as tools for drug discovery

Jelena Urosevic, Eleanor Y. M. Sum, Victoria Moneo, Matthias Drosten et autres

Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors that target those kinases acting …

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

Carmen E. Guerra, Nieves Mijimolle, Alma Dhawahir, Pierre R. Dubus et autres

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