David Mark Olson

Maternal and Postnatal Effects of Poly I:C‐Induced Intrauterine Inflammation and Rytvela, a Non‐Competitive IL‐1R Antagonist, in the Pregnant Spiny Mouse

Nhi Thao Tran, Rachid Kamareddine, Nadia Bellofiore, David Mark Olson et autres

Maternal infection-induced inflammation during pregnancy is associated with adverse neurodevelopment. Rytvela, an allosteric IL-1 receptor antagonist, reduces IL-1β-mediated pathology in fetal rodents and sheep. However, its effects on TLR3-mediated inflammation and subsequent offspring growth and behavior remain unclear. Using precocial spiny mice, …

au, ca (code pays fourni par la source)

Impact of Prenatal Stress on Autonomic Nervous System Functioning and Psychopathology Risk in Early Childhood: The Harvey Mom Study

Rebecca S. Lipschutz, Suzanne King, Carla Sharp, Dana DeMaster et autres

ABSTRACT Prior human and animal research suggests prenatal stress alters developmental systems that support stress and emotion regulation in offspring, which may underlie vulnerability to psychopathology risk. We examined prospective associations between prenatal stress from a natural disaster and infant biobehavioral outcomes …

us, ca (code pays fourni par la source)

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Kerrie L. Foyle, Ella S. Green, Jessie R Walker-Rogers, Ha M. Tran et autres

Inflammation is a major driver of preterm birth, a common pregnancy disorder and the leading cause of childhood death. T regulatory (Treg) cells are essential mediators of maternal fetal tolerance and are critical for constraining uterine inflammation. In some tissue settings, loss …

au, ca (code pays fourni par la source)

Rytvela, an allosteric modulator of the interleukin-1 receptor, prevents preterm birth and neonatal complications in mice while nifedipine is ineffective

Tiffany Habelrih, Béatrice Ferri, Sarah‐Eve Loiselle, Félix Mauffette-Whyte et autres

Preterm birth is the leading cause of neonatal morbidity and mortality. Management of preterm labor relies on the use of tocolytics, like nifedipine, which fail to prevent preterm birth and related morbidities. Interleukin-1β plays significant roles in the pathophysiology of preterm birth …

ca (code pays fourni par la source)

D-PLACE dataset derived from Olson et al. 2001 'Terrestrial Ecoregions of the World'

David Mark Olson, Eric Dinerstein, Eric Wikramanayake, Neil Burgess et autres

Cite the source of the dataset as: Olson, D. M., Dinerstein, E., Wikramanayake, E. D., Burgess, N. D., Powell, G. V. N., Underwood, E. C., D'Amico, J. A., Itoua, I., Strand, H. E., Morrison, J. C., Loucks, C. J., Allnutt, T. F., …

Perceptions and experiences of patients, caregivers, and clinicians on using digital phenotyping measures for outcome prediction in first episode of psychosis (FEP): A qualitative study

Lu Yang, Kate Ross, Katie Joan Stewart, Qiang Ye et autres

Background : Predicting outcomes in first-episode psychosis (FEP) is critical for tailoring interventions. Digital phenotyping, the real-time collection of high-resolution data through mobile and wearable devices, has emerged as a promising method to improve mental health assessment and prognostic prediction. Objective : …

ca (code pays fourni par la source)

Spatio-temporal variation in the distribution of great apes in the Dja-Ngoyla Complex in Cameroon, and implications for conservation

Oliver Fankem, Anne Stephanie Kobla, Tom Bruce, Gilbert Oum Ndjock et autres

Abstract Central African great ape populations are in serious decline as a result of poaching, habitat loss and disease. Reliable estimates of population size are urgently needed for informed management action. We estimate the abundance and distribution of central chimpanzee Pan troglodytes …

Cameroun, gb, au, cn, ru (code pays fourni par la source)

A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome

France Côté, Élizabeth Prairie, Estefania Marin Sierra, Christiane Quiniou et autres

Preterm birth (PTB) is a major cause of neonatal mortality and morbidity. Evidence supports a determinant role for interleukin-6 (IL-6) in the pathophysiology of PTB. Our group developed a small peptide, HSJ633, that antagonizes the interleukin-6 receptor (IL-6R). Binding assays performed on …

ca, au (code pays fourni par la source)

The conservation status of the threatened gazelles of Ar Rub’ al-Khālī, Saudi Arabia

Tim Wacher, Ahmed Alboug, Chris Barichievy, Zaffar Rais Mir et autres

The Arabian gazelle ( Gazella arabica ) and Arabian sand gazelle ( G. marica ) are globally threatened. In ongoing restoration efforts within Saudi Arabia, 240 captive-bred sand gazelles and 73 Arabian gazelles were reintroduced to the 12,684 km 2 Uruq Bani …

gb, sa, au, cn (code pays fourni par la source)

Corrigendum to “Transgenerational transmission of prenatal maternal stress across three generations of male progeny alters inflammatory stress markers in reproductive tissues” [Psychoneuroendocrinology 177 (2025) 107451]

Nayara Antunes Lopes, Mirela Ambeskovic, Stephanie E. King, Jamshid Faraji et autres

ca (code pays fourni par la source)

Risk factors for cholera mortality: A scoping review

Despina Pampaka, Kathryn P. Alberti, David Mark Olson, Iza Ciglenečki et autres

OBJECTIVES: Cholera is an easily treatable disease, but many people are still unnecessarily dying from it. To improve current case management practices and prevent mortality requires a comprehensive understanding of who is at higher risk of dying. To identify the most common …

ch (code pays fourni par la source)

Transgenerational transmission of prenatal maternal stress across three generations of male progeny alters inflammatory stress markers in reproductive tissues

Nayara Antunes Lopes, Mirela Ambeskovic, Stephanie E. King, Jamshid Faraji et autres

Prenatal maternal stress may lead to adverse pregnancy outcomes such as preterm birth and low birth weight. Our team has demonstrated in multiple rat models that prenatal maternal stress modifies the expression of inflammatory and stress regulators in the uterus and that …

ca (code pays fourni par la source)