Lise Grupe Larsen

Endometrial immune markers are upregulated in the proliferative and secretory phases in recurrent pregnancy loss

Lærke Heidam J. Andersen, Kristine Juul Hare, Jan Palmø, Sophie Brondt Salby et autres

Immune factors in the endometrium of women with recurrent pregnancy loss (RPL) appear to play a crucial role in the pathophysiology of a subset of RPL patients. Differences in the expression of five immune markers, CD138 (plasma cells), CD56 (uterine natural killer …

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Six‐pattern p53 interpretation in 1293 vulvar squamous cell carcinomas: inter‐pathologist variation and pattern distribution according to p16 status

Emma L. Kaderly Rasmussen, Susanne K. Kjær, Lise Grupe Larsen, Else Mejlgaard et autres

AIMS: Vulvar squamous cell carcinoma (VSCC) is classified into human papillomavirus (HPV)-associated and HPV-independent types, primarily using p16 immunohistochemistry, with p53 staining playing a complementary role since a subset of HPV-independent VSCC is driven by TP53 mutations. We aimed to assess the …

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Prognostic impact of p16 and high‐risk HPV DNA in ~1300 patients with vulvar cancer

Susanne K. Kjær, Kirsten Frederiksen, Christina Louise Rasmussen, Louise T. Thomsen et autres

The study aimed to investigate whether vulvar squamous cell carcinoma (VSCC) survival varies by human papillomavirus (HPV) status measured by p16 expression and to determine whether high-risk HPV (hrHPV) DNA detection adds further prognostic information. Our cohort included 1277 women with histologically …

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Upregulation of immune genes in the proliferative phase endometrium enables classification into women with recurrent pregnancy loss versus controls

Laerke Heidam Juul Andersen, Raquel Martínez, Yifan Dai, Jens Ole Eriksen et autres

STUDY QUESTION: Does the transcriptome of preconceptional endometrium in the proliferative phase show a specific profile in women with recurrent pregnancy loss (RPL)? SUMMARY ANSWER: A specific differential gene expression signature in endometrial samples for women experiencing RPL compared with IVF control …

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Development of a digital algorithm for assessing tumor-stroma ratio, tumor budding and tumor infiltrating lymphocytes in vulvar squamous cell carcinomas

Louise Baandrup, Susanne K. Kjær, Óli Jacobsen, Michael Bzorek et autres

Tumor-stroma ratio (TSR), tumor budding (TB), and tumor-infiltrating lymphocytes (TILs) are prognostic markers in some cancers but with unknown significance in vulvar squamous cell carcinoma (VSCC). This pilot study primarily aimed to develop a digital method for evaluating TSR, TB and TILs …

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Opposing impacts of HLA-G haplotypes PROMO-G010104-UTR-3 and PROMO-G010101b/c-UTR-4 on risk of recurrent implantation failure

Henrieta Papúchová, Malene Hviid Saxtorph, Trine Hallager, Ida Engberg Jepsen et autres

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A cervical screening initiative for elderly women in Denmark

Malene Skorstengaard, Petra Hall Viborg, Ane Birgitte Telén Andersen, Berit Andersen et autres

INTRODUCTION: To assess outcome of a one-time human papillomavirus (HPV)-screening in 2017 of Danish women aged 70+. MATERIAL AND METHODS: Women born 1947 or before were personally invited to have a cell-sample collected by their general practitioner. Screening- and follow-up samples were …

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Time trends in prevalence of p16 positivity and combined HPV /p16 positivity in a large cohort of Danish vulvar cancer patients

Christina Louise Rasmussen, Louise T. Thomsen, Louise Baandrup, Maria Franzmann et autres

Vulvar cancer is rare, but causes substantial morbidity in affected patients. A subset of vulvar cancers is caused by high-risk human papillomavirus (hrHPV), which primarily exerts its oncogenic effect through upregulation of tumor suppressor protein p16. Tumors positive for both hrHPV and …

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Changes in HPV prevalence in Danish women with vulvar cancer during 28 years – A nationwide study of >1300 cancer cases

Christina Louise Rasmussen, Louise T. Thomsen, Louise Baandrup, Maria Franzmann et autres

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Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients

Henrieta Papúchová, Malene Hviid Saxtorph, Trine Hallager, Ida Engberg Jepsen et autres

STUDY QUESTION: Is human leukocyte antigen (HLA)-F protein expressed in mid-secretory endometrium, and are its expression levels influenced by HLA-F gene polymorphisms and correlated with the abundance of uterine natural killer (uNK) cells and anti-inflammatory M2 macrophages? SUMMARY ANSWER: HLA-F protein is …

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Conventional microscopy versus digital image analysis for histopathologic evaluation of immune cells in the endometrium

Trine Hallager, Malene Hviid Saxtorph, Jens Ole Eriksen, Thomas Vauvert F. Hviid et autres

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Histological outcomes in HPV-screened elderly women in Denmark

Gry St‐Martin, Petra Hall Viborg, Ane Birgitte Telén Andersen, Berit Andersen et autres

INTRODUCTION: Danish women exit cervical cancer screening at age 65 years, but 23% of cervical cancer cases occur beyond this age. In addition, due to gradual implementation of cervical cancer screening, older women are underscreened by today´s standards. A one-time screening with …

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