Atharva Sahasrabudhe

Attenuation of Inflammatory Cytokines by Selective Vagal Motor Stimulation via Silicone Spiral Nerve Cuff

Kathryn S. Mirandette, Atharva Sahasrabudhe, Magdalena Slowikowski, John H. Caldwell et autres

Abstract Objectives To determine how selective optogenetic vagus nerve stimulation (VNS) of distinct axonal subpopulations modulates systemic inflammatory cytokines in an acute model of endotoxemia. Materials and Methods A silicone spiral nerve cuff with integrated custom probes including microscale light-emitting diodes (μLEDs) …

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Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation

Shriya S. Srinivasan, Marc‐Joseph Antonini, Amro Alshareef, Atharva Sahasrabudhe et autres

Gastrointestinal (GI) dysmotility and associated conditions affect over 20% of population, yet pharmacological, behavioural, and surgical interventions offer limited therapeutic efficacy. Targeted electrical stimulation addressing underlying neuromuscular pathology stands to transform our ability to treat dysmotility. Here, we developed a closed-loop GI …

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Artificial Optoelectronic Synapse Featuring Bidirectional Post‐Synaptic Current for Compact and Energy‐Efficient Neural Hardware (dAdv. Mater. 34/2025)

Hogeun Ahn, Yena Kim, Seunghwan Seo, Jun‐Seo Lee et autres

Artificial Optoelectronic Synapse In article number 2418582, Jin-Hong Park, Saeroonter Oh, and co-workers present an artificial optoelectronic synapse capable of bidirectional post-synaptic current modulation. This innovative design eliminates the need for differential synapse pairs while supporting essential synaptic functions. A fabricated synapse …

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A gut sense for a microbial pattern regulates feeding

Winston W. Liu, Naama Reicher, Emily Alway, Laura E. Rupprecht et autres

To coexist with its resident microorganisms, the host must have a sense to adjust its behaviour in response to them. In the intestine, a sense for nutrients transduced to the brain through neuroepithelial circuits guides appetitive choices1–5. However, a sense that allows …

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Artificial Optoelectronic Synapse Featuring Bidirectional Post‐Synaptic Current for Compact and Energy‐Efficient Neural Hardware

Hogeun Ahn, Yena Kim, Seunghwan Seo, Jun‐Seo Lee et autres

Abstract Conventional hardware neural networks (HW‐NNs) have relied on unidirectional current flow of artificial synapses, necessitating a differential pair of the synapses for weight core implementation. Here, an artificial optoelectronic synapse capable of bidirectional post‐synaptic current ( I PSC ) is presented, …

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Accessing the viscera: Technologies for interoception research

Karen Ka Lam Pang, Rajib Mondal, Atharva Sahasrabudhe, Polina O. Anikeeva

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Multifunctional bioelectronics for brain–body circuits

Atharva Sahasrabudhe, Claudia Cea, Polina O. Anikeeva

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Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo

Sizhe Huang, Ruobai Xiao, Shaoting Lin, Geunho Jang et autres

Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking neural activity with behaviors. Utilizing the self-alignment of nano-fillers in a polymeric matrix under repetitive tension, here, we introduce conductive carbon nanotubes with high aspect …

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Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich et autres

Recording and modulation of neuronal activity enables the study of brain function in health and disease. While translational neuroscience relies on electrical recording and modulation techniques, mechanistic studies in rodent models leverage genetic precision of optical methods, such as optogenetics and fluorescent …

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Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation

Ye Ji Kim, Noah Kent, Emmanuel Vargas Paniagua, Nicolette Driscoll et autres

Abstract Deep brain stimulation with implanted electrodes has transformed neuroscience studies and treatment of neurological and psychiatric conditions. Discovering less invasive alternatives to deep brain stimulation could expand its clinical and research applications. Nanomaterial-mediated transduction of magnetic fields into electric potentials has …

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Anisotropic Hydrogel Microelectrodes for Intraspinal Neural Recordings in vivo

Siyuan Rao, Sizhe Huang, Ruobai Xiao, Shaoting Lin et autres

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Fiber-based Probes for Electrophysiology, Photometry, Optical and Electrical Stimulation, Drug Delivery, and Fast-Scan Cyclic Voltammetry In Vivo

Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich et autres

Recording and modulation of neuronal activity enables the study of brain function in health and disease. While translational neuroscience relies on electrical recording and modulation techniques, mechanistic studies in rodent models leverage genetic precision of optical methods, such as optogenetics and imaging …

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