Charles Dobard

Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and Is Associated with Immune Alterations

Michele B. Daly, Daniel Kim, Seidu Inusah, Dawn Little et autres

Background: Islatravir (ISL) is a first-in-class nucleoside reverse transcriptase translocation inhibitor with high potency and long half-life in peripheral blood mononuclear cells (PBMCs). However, treatment and prevention of HIV with oral ISL in humans has been associated with decreases in total lymphocytes, …

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A subcutaneous implant that releases islatravir provides long-lasting protection against vaginal SHIV infection in macaques

Michele B. Daly, Daniel Kim, Archana Krovi, Linying Li et autres

us, Ouganda, Kenya (code pays fourni par la source)

Pharmacokinetic Study of Islatravir and Etonogestrel Implants in Macaques

Ariane van der Straten, Josilene Nascimento Seixas, Catalina Forero, Victoria Mrotz et autres

The prevention of HIV and unintended pregnancies is a public health priority. Multi-purpose prevention technologies capable of long-acting HIV and pregnancy prevention are desirable for women. Here, we utilized a preclinical macaque model to evaluate the pharmacokinetics of biodegradable ε-polycaprolactone implants delivering …

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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Alka Prasher, Ivana Massud, Josilene Nascimento Seixas, S. Rahima Benhabbour et autres

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Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Josilene Nascimento Seixas, Stephanie A. Montgomery, Allison Thorson, Isabella C. Young et autres

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Defining blood hematology reference values in female pig‐tailed macaques (Macaca nemestrina) using the Isolation Forest algorithm

Daniel Kim, Abigail Derton, George Khalil, Yi Pan et autres

BACKGROUND: Pig-tailed macaques (PTMs) are commonly used as preclinical models to assess antiretroviral drugs for HIV prevention research. Drug toxicities and disease pathologies are often preceded by changes in blood hematology. To better assess the safety profile of pharmaceuticals, we defined normal …

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Weekly Oral Tenofovir Alafenamide Protects Macaques from Vaginal and Rectal Simian HIV Infection

Ivana Massud, Kenji Nishiura, Susan Ruone, Angela Holder et autres

Pre-exposure prophylaxis (PrEP) with a weekly oral regimen of antiretroviral drugs could be a suitable preventative option for individuals who struggle with daily PrEP or prefer not to use long-acting injectables. We assessed in macaques the efficacy of weekly oral tenofovir alafenamide …

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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava et autres

The original version of this Article contained an error in the third and fourth sentence of the Methods section under heading ‘SHIV challenge study in rhesus macaques’, which incorrectly read ‘The final challenge stock was diluted to 10 TCID50 and stored individually …

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Pharmacokinetic Study of Islatravir and Etonogestrel Implants in Macaques

Michele B. Daly, Andres Wong-Sam, Lingying Li, Sai Archana Krovi et autres

The prevention of HIV and unintended pregnancies is a public health priority. Multi-purpose prevention technologies capable of long-acting HIV and pregnancy prevention are desirable for women. Here, we utilized a preclinical macaque model to evaluate the pharmacokinetics of biodegradable ε-polycaprolactone implants delivering …

us (code pays fourni par la source)

Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava et autres

Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administered subcutaneously and can release the integrase inhibitor cabotegravir (CAB) above protective …

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Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques

Charles Dobard, M. Melissa Peet, Kenji Nishiura, Angela Holder et autres

BACKGROUND: Vaginal products for HIV prevention that can be used on-demand before or after sex may be a preferable option for women with low frequency or unplanned sexual activity or who prefer not to use daily or long-acting pre-exposure prophylaxis (PrEP). We …

us, Ouganda, Kenya (code pays fourni par la source)

Safety and efficacy of a biodegradable implant releasing tenofovir alafenamide for vaginal protection in a macaque model

Ivana Massud, Sai Archana Krovi, Kenji Nishiura, Susan Ruone et autres

OBJECTIVES: To advance the initiative of ending the global epidemic, long-lasting HIV protection is needed through sustained release of antiretroviral drugs for months to years. We investigated in macaques the safety and efficacy of biodegradable polycaprolactone implants releasing tenofovir alafenamide for HIV …

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