Allison Thorson

Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy

Craig Sykes, Rima Janusziewicz, Angela D. M. Kashuba, S. Rahima Benhabbour et autres

Globally, there are 20 million adolescent girls and young women living with HIV who have limited access to long-acting, effective, women-controlled preventative methods. Additionally, although there are many contraceptive methods available, globally, half of all pregnancies remain unintended. Here we report the …

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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Alka Prasher, Ivana Massud, Josilene Nascimento Seixas, S. Rahima Benhabbour et autres

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Next-Generation Contraceptive Intravaginal Ring: Comparison of Etonogestrel and Ethinyl Estradiol In Vitro and In Vivo Release from 3D-Printed Intravaginal Ring and NuvaRing

Allison Thorson, Isabella C. Young, S. Rahima Benhabbour, Kathleen L. Vincent et autres

Intravaginal rings (IVRs) represent a well-established, woman-controlled and sustained vaginal drug delivery system suitable for a wide range of applications. Here, we sought to investigate the differences in etonogestrel (ENG) and ethinyl estradiol (EE) release from a 3D-printed IVR utilizing continuous liquid …

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Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Josilene Nascimento Seixas, Stephanie A. Montgomery, Allison Thorson, Isabella C. Young et autres

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Next-Generation Contraceptive Intravaginal Ring: Comparison of Etonogestrel and Ethinyl Estradiol In Vitro and In Vivo Release from 3D-Printed Intravaginal Ring and NuvaRing

Isabella C. Young, Allison Thorson, Mackenzie L. Cottrell, Craig Sykes et autres

Intravaginal rings (IVRs) represent a well-established, woman-controlled and sustained vaginal drug delivery system suitable for a wide range of applications. Here, we sought to investigate the differences in etonogestrel (ENG) and ethinyl estradiol (EE) release from a 3D-printed IVR utilizing continuous liquid …

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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava et autres

The original version of this Article contained an error in the third and fourth sentence of the Methods section under heading ‘SHIV challenge study in rhesus macaques’, which incorrectly read ‘The final challenge stock was diluted to 10 TCID50 and stored individually …

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Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy

Isabella C. Young, Priya Srinivasan, Roopali Shrivastava, Rima Janusziewicz et autres

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Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant

Angela D. M. Kashuba, S. Rahima Benhabbour, Craig Sykes, Mackenzie L. Cottrell et autres

HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges with daily oral prevention regimens by reducing dosing frequency and stigma. We previously developed an ultra-long-acting injectable, biodegradable, and removeable …

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Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant

Isabella C. Young, Allison Thorson, Roopali Shrivastava, Craig Sykes et autres

HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges with daily oral prevention regimens by reducing dosing frequency and stigma. We previously developed an ultra-long-acting injectable, biodegradable, and removeable …

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Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava et autres

Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administered subcutaneously and can release the integrase inhibitor cabotegravir (CAB) above protective …

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