Brachytherapy Combined with Cuproptosis-Inducing Radiosensitizer Overcomes Radioresistance in Triple-Negative Breast Cancer
Xue Wang, Chenglu Gu, Jie Zhang, Xihong Guo et autres
Acquired radioresistance remains a major clinical obstacle in triple-negative breast cancer (TNBC) radiotherapy. Here, we first report the combined use of an ultrasmall copper-doped hafnium oxide nanoradiosensitizer (US-HfO2:Cu, ∼10 nm) and 192Ir brachytherapy (BT) to address this issue. BT triggers radiation-responsive Cu+ …
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Nano Letters