Brett Kinrade

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

Mingyu Wang, Guocheng Du, Charity Deborah Yongo-Luwawa, Albert K. Lu et autres

Vibrio cholerae, the causative agent of cholera, uses surface proteins such as the repeats-in-toxin (RTX) adhesin FrhA to colonize hosts and initiate infection. Blocking bacterial adhesion represents a promising therapeutic strategy to treat infections without promoting drug resistance. FrhA contains a peptide-binding …

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Peptide-based ligand antagonists block a Vibrio cholerae adhesin

Guocheng Du, Charity Deborah Yongo-Luwawa, Albert K. Lu, Brett Kinrade et autres

Abstract Vibrio cholerae , the causative agent of cholera, uses surface proteins such as the repeats-in-toxin (RTX) adhesin FrhA to colonize hosts and initiate infection. Blocking bacterial adhesion represents a promising therapeutic strategy to treat infections without promoting drug resistance. FrhA contains …

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Adhesin domains responsible for binding bacteria to surfaces they colonize project outwards from companion split domains

Laurie A. Graham, Thomas Hansen, Yanzhi Yang, Mustafa Sherik et autres

Bacterial adhesins attach their hosts to surfaces that the bacteria will colonize. This surface adhesion occurs through specific ligand-binding domains located towards the distal end of the long adhesin molecules. However, recognizing which of the many adhesin domains are structural and which …

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Author response for "Adhesin domains responsible for binding bacteria to surfaces they colonize project outwards from companion split domains"

Laurie A. Graham, Thomas Hansen, Yanzhi Yang, Mustafa Sherik et autres

A peptide-binding domain shared with an Antarctic bacterium facilitates Vibrio cholerae human cell binding and intestinal colonization

Shuaiqi Guo, Brett Kinrade, Hossein Shahbani Zahiri, Robert Leo Eves et autres

Vibrio cholerae, the causative agent of the disease cholera, is responsible for multiple pandemics. V. cholerae binds to and colonizes the gastrointestinal tract within the human host, as well as various surfaces in the marine environment (e.g., zooplankton) during interepidemic periods. A …

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Blocking Vibrio cholerae-mediated hemagglutination with short peptide antagonists

Shuaiqi Guo, Brett Kinrade, Mustafa Sherik, Ilja Karina Voets et autres

Many bacteria use repeats-in-toxin (RTX) adhesins to mediate binding to host cells and facilitate subsequent colonisation and infection by forming biofilms. Vibrio cholerae, the causative agent of cholera, uses a 230-kDa RTX adhesin, FrhA, to facilitate intestinal colonization. FrhA also mediates hemagglutination …

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Bacterial sugar-binding protein as a one-step affinity purification tag on dextran-containing resins

Brett Kinrade, Peter L. Davies, Tyler D. R. Vance

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