Hideharu Funatsu

Silent Information Regulator T1 in Aqueous Humor of Patients with Age-Related Macular Degeneration

Tatsuya Mimura, Hideharu Funatsu, Hidetaka Noma, Aki Kondo et autres

Purpose: The purpose of this study is to compare the aqueous humor level of Silent Information Regulator T1 (SIRT1) between patients with Age-related Macular Degeneration (AMD) and cataract patients. Materials and Methods: Aqueous humor level of SIRT1 was measured by enzyme-linked immunosorbent …

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Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

Tatsuya Mimura, Hideharu Funatsu, Hidetaka Noma, Masahiko Shimura et autres

PURPOSE: To compare aqueous humor levels of various cytokines between patients with age-related macular degeneration (AMD) and cataract patients. METHODS: Thirteen eyes with wet-type AMD (AMD group) and 14 eyes with cataract (cataract group) were studied. Aqueous humor levels of 11 factors …

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Glycolysis in Patients with Age-Related Macular Degeneration

Kanako Yokosako, Tatsuya Mimura, Hideharu Funatsu, Hidetaka Noma et autres

PURPOSE: Retinal adenosine triphosphate is mainly produced via glycolysis, so inhibition of glycolysis may promote the onset and progression of age-related macular degeneration (AMD). When glycolysis is inhibited, pyruvate is metabolized by lactic acid fermentation instead of entering the mitochondrial tricarboxylic acid …

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Retinal Neuroprotective Effect of Sirtuins

Tatsuya Mimura, Hidetaka Noma, Hideharu Funatsu, Aki et autres

In this paper, we review current knowledge about the retinal neuroprotective effect of sirtuins. The sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases that are involved in mammalian diseases of aging. The human genome encodes seven different sirtuins (SIRT1-7). SIRT1 …

The role of SIRT1 in ocular aging

Tatsuya Mimura, Yuichi Kaji, Hidetaka Noma, Hideharu Funatsu et autres

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Epigenetic Regulation of Retinal Stem Cells

Toshihide Mimura, Hisashi Noma, Hideharu Funatsu

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Influence of Pars Plana Vitrectomy on Macular Sensitivity and Morphology in Patients with Branch Retinal Vein Occlusion and Serous Retinal Detachment

Hidetaka Noma, Hideharu Funatsu, Katsunori Shimada, Tatsuya Mimura

BACKGROUND AND OBJECTIVE: To evaluate the influence of serous retinal detachment (SRD) on the outcome of pars plana vitrectomy (PPV) for macular edema in patients with branch retinal vein occlusion (BRVO). PATIENTS AND METHODS: In an interventional case series, 20 patients (20 …

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Association of electroretinographic parameters and inflammatory factors in branch retinal vein occlusion with macular oedema

Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura

BACKGROUND/AIMS: Branch retinal vein occlusion (BRVO) leads to retinal ischaemia, which then induces upregulation of various inflammatory factors, including vascular endothelial growth factor (VEGF). The aim of this study was to determine whether there was a correlation between inflammatory factors and components …

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Changes of Inflammatory Factors After Intravitreal Triamcinolone Acetonide for Macular Edema with Central Retinal Vein Occlusion

Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura

PURPOSE: To investigate the effect of intravitreal triamcinolone acetonide (TA) on aqueous humor levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule 1 (sICAM-1), and pigment epithelium-derived factor (PEDF) in patients with central retinal vein occlusion (CRVO) and macular edema. …

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Comparison of the efficacy of intravitreal triamcinolone acetonide for cystoid macular edema with versus without serous retinal detachment in branch retinal vein occlusion: influence on macular sensitivity and morphology

Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura, Katsunori Shimada

BACKGROUND: The influence of serous retinal detachment (SRD) on visual acuity, macular sensitivity, and macular thickness is unclear after intravitreal injection of triamcinolone acetonide (IVTA) for macular edema with branch retinal vein occlusion (BRVO). METHODS: Twenty-one eyes of 21 BRVO patients with …

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MACULAR SENSITIVITY AND MORPHOLOGY AFTER INTRAVITREAL INJECTION OF TRIAMCINOLONE ACETONIDE FOR MACULAR EDEMA WITH BRANCH RETINAL VEIN OCCLUSION

Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura, Katsunori Shimada

In Brief Purpose: To evaluate the changes of macular sensitivity, thickness, and total macular volume after intravitreal injection of triamcinolone acetonide to treat macular edema with branch retinal vein occlusion. Methods: Seventeen eyes of 17 patients with branch retinal vein occlusion with …

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Pigment epithelium-derived factor is related to macular microcirculation in patients with macular edema and branch retinal vein occlusion

Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura

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