Muriel Brackstone

Real-World Toxicities and Outcomes of Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Emmanuel Joran Boujeke, Aaron Catalan, Laurice Arayan, Alfred Patrick Mina et autres

Purpose: Pembrolizumab combined with chemotherapy is the standard of care for early-stage triple-negative breast cancer (TNBC) following KEYNOTE-522. However, real-world data on immune-related adverse events (irAEs) remain limited. We evaluated the incidence, severity, and clinical consequences of irAEs in a real-world cohort …

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Tumour-infiltrating lymphocytes and breast radiotherapy: perspectives from the International Immuno-Oncology Biomarker Working Group

Jetske L B Gunster, Trine Tramm, Melanie Machiels, Sandra Demaria et autres

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Spatial proteomic profiling reveals an association between NF1-Ras/Raf/MEK signaling and immune cell infiltration in locally advanced triple-negative breast cancer

Vasudeva K. Bhat, Emily A. Goebel, Carl Postenka, Anayra de Fátima Gonçalves Santiago et autres

BACKGROUND: Triple-negative breast cancer (TNBC) is a highly aggressive malignancy characterized by significant molecular heterogeneity with a limited range of targeted therapy options. Better resolution of the spatial interactions between tumor cells and the immune microenvironment is essential for identifying actionable vulnerabilities. …

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Laparoscopically Harvested Pedicled Omental Flap in Immediate Unilateral Breast Reconstruction: A Systematic Review of Surgical Techniques and Clinical Outcomes

Annie M. Wu, Surabi Thirugnanasampanthar, Muriel Brackstone

Laparoscopically harvested pedicled omental flap (LHPOF) reconstruction is a minimally invasive autologous option for immediate breast reconstruction, but prior reviews have largely examined omental flaps broadly, combining open and laparoscopic harvests, free and pedicled transfers, and mixed reconstructive indications. This systematic review …

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Understanding the needs of breast cancer patients who have experienced intimate partner violence: Implications for trauma- and violence-informed care

Cara Anne Davidson, Kimberley T. Jackson, Muriel Brackstone, Tara Mantler

Trauma- and violence-informed care (TVIC) aims to minimize re-traumatization and promote equitable outcomes for women who have experienced intimate partner violence (IPV). Breast cancer (BC) patients with trauma histories may delay or avoid care due to fear of re-traumatization, compromising outcomes. This …

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Spatial proteomic profiling reveals an association between NF1-Ras/Raf/MEK signaling and immune cell infiltration in locally advanced triple-negative breast cancer

Vasudeva K. Bhat, Emily A. Goebel, Carl Postenka, Anayra Santiago et autres

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Salvage of a laparoscopically harvested omental flap by conversion to a free flap with microanastomosis to thoracodorsals for immediate breast reconstruction

Annie Wu, Sarah Appleton, Muriel Brackstone, Ahmad Elnahas et autres

We describe intraoperative salvage of a planned pedicled omental flap for immediate breast reconstruction by conversion to a free omental flap with microanastomosis to the serratus branch of the thoracodorsal recipient pedicle. To our knowledge, this is among the earliest North American …

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Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer

Nikki Salmond, Renata Moravcova, Karan Khanna, Jason C. Rogalski et autres

Diagnosis of stage 1 breast cancer is challenging as small tumors are often left undetected by conventional imaging techniques. In addition, ~80% of detected breast masses are classified as benign, which means that a large proportion of diagnostic needle biopsies lead to …

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Clinical Validation of Digital PCR-based ctDNA detection for risk stratification in residual triple negative breast cancer: TRICIA trial results

Talia Roseshter, Anna Klemantovich, Josiane Lafleur, Cathy Lan et autres

Abstract Triple-negative breast cancer (TNBC) patients who have residual tumor at surgery (non-pathological complete response or non-pCR) after neoadjuvant chemotherapy (NAC) have a poor prognosis. In these cases, adjuvant chemotherapy with capecitabine improves disease-free survival in ∼15% of patients. Identifying those who …

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Postmastectomy Breast Reconstruction in Patients with Non-Metastatic Breast Cancer: An Ontario Health (Cancer Care Ontario) Clinical Practice Guideline

Toni Zhong, Glenn George Fletcher, Muriel Brackstone, Simon G. Frank et autres

Several postmastectomy breast reconstruction techniques and procedures have been implemented, although with limited evaluation of benefits and adverse effects. We conducted a systematic review on the plane and timing of reconstruction, and on the use of nipple-sparing mastectomy, acellular dermal matrix, and …

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Clinical Significance of Tumor Grade in Triple-Negative Breast Cancer: A Retrospective Cohort Analysis

Neya Ramanan, Mah-noor Malik, Sarang Upneja, Swati Kulkarni et autres

Triple-negative breast cancer (TNBC) is a heterogeneous cancer that lacks estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2) proteins. Here, we investigated the prognostic value of grade in patients with TNBC. Methods: This retrospective study analyzed …

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Postmastectomy Breast Reconstruction in Patients with Non-Metastatic Breast Cancer: A Systematic Review

Toni Zhong, Glenn George Fletcher, Muriel Brackstone, Simon G. Frank et autres

Breast reconstruction after mastectomy improves the quality of life for many patients with breast cancer. There is uncertainty regarding eligibility criteria for reconstruction, timing (immediate or delayed-with or without radiotherapy), outcomes of nipple-sparing compared to skin-sparing mastectomy, selection criteria and surgical factors …

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