Nader Rahimi

Indoxyl Sulfate Promotes Uremic Arterial and Venous Thrombosis by Stabilizing IDO1 via the E3 Ligase SHFM3

Ricardo Almiron, Abbas Brahim Malloum, Saran Lotfollahzadeh, Kashvi Sethuraman et autres

BACKGROUND: The uremic milieu of chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins, which contribute to thrombosis. Indoxyl sulfate, a bona fide uremic toxin, upregulates indoleamine 2,3-dioxygenase 1 (IDO1), thereby augmenting kynurenine biogenesis. Both toxins activate tissue …

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Mercury exposure, but not lead, increases risk of gestational diabetes mellitus: a meta-analysis

Armineh Rezagholi Lalani, Nader Rahimi, Zhasman Adib, Nima Rastegar Pouyani et autres

Gestational diabetes mellitus (GDM) is a growing health problem causing a higher risk of delivering large infants and experiencing maternal and neonatal mortality. Studies have found a link between increased levels of mercury (Hg) and lead (Pb) in the blood and a …

Mercury exposure, but not lead, increases risk of gestational diabetes mellitus: a meta-analysis

Armineh Rezagholi Lalani, Nader Rahimi, Zhasman Adib, Nima Rastegar Pouyani et autres

Gestational diabetes mellitus (GDM) is a growing health problem causing a higher risk of delivering large infants and experiencing maternal and neonatal mortality. Studies have found a link between increased levels of mercury (Hg) and lead (Pb) in the blood and a …

Mercury exposure, but not lead, increases risk of gestational diabetes mellitus: a meta-analysis

Armineh Rezagholi Lalani, Nader Rahimi, Zhasman Adib, Nima Rastegar Pouyani et autres

Gestational diabetes mellitus (GDM) is a growing health problem causing a higher risk of delivering large infants and experiencing maternal and neonatal mortality. Studies have found a link between increased levels of mercury (Hg) and lead (Pb) in the blood and a …

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Human TMIGD1 Promoter Exhibits Robust Activity in Prokaryotic Cells

Rosana Meyer, Kaneyoshi Yamamoto, Bridget Whelpley, Daniel R. Dempsey et autres

Gene transcription in eukaryotes is orchestrated by intricate regulatory architectures that depend on chromatin context and a diverse repertoire of transcription factors. Consequently, eukaryotic promoters are thought to be incompatible with the streamlined transcriptional machinery of bacteria. Here, we challenge this assumption …

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IGPR-1 Is Phosphorylated on the Immunoreceptor Tyrosine-Based Motif, Stimulates the AKT Pathway and Supports Melanoma Growth

Nader Rahimi, Sreesaisowmya Potluri, Vipul Chimanlal Chitalia

Immunoglobulin (Ig) and Proline-rich Receptor-1 (IGPR-1, also called TMIGD2) is closely related to immune checkpoint CD28/PDL1 family receptors. It controls important cellular processes, including immune cell regulation, cell-cell adhesion, mechanosensing, and autophagy, and its activity is associated with multiple human malignancies. However, …

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Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]

Saran Lotfollahzadeh, Chaoshuang Xia, Razie Amraei, Hua Ning et autres

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WHORL

Daniel Tourevski, Emiliya Akhundova, Joshua Choi, M. Ndege et autres

Art magazine featuring the creative work of students, faculty and staff of the Boston University Medical Campus and Boston Medical Center

IGPR-1 is phosphorylated on the immunoreceptor tyrosine-based motif, stimulates AKT pathway and supports melanoma growth

Nader Rahimi, Sreesaisowmya Potluri, Vipul Chimanlal Chitalia

ABSTRACT Melanoma is a lethal form of skin cancer that impacts one out of every five Americans and ranks as the fifth most prevalent cancer among men and women in the United States. Immunoglobulin (Ig) and Proline-rich Receptor-1 (IGPR-1, also called TMIGD2/CD28H) …

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WHORL

Margaret S. Lee, Tri Do, A Aghi, Keith Tornheim et autres

Art magazine featuring the creative work of students, faculty and staff of the Boston University Medical Campus and Boston Medical Center

Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity

Nader Rahimi, Mitchell R. White, Razie Amraei, Saran Lotfollahzadeh et autres

Cardiovascular complications are major clinical hallmarks of acute and post-acute coronavirus disease 2019 (COVID-19). However, the mechanistic details of SARS-CoV-2 infectivity of endothelial cells remain largely unknown. Here, we demonstrate that the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein …

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Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury

Mostafa Belghasem, Wenqing Yin, Saran Lotfollahzadeh, Xiaosheng Yang et autres

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