Parmida Sadat Pezeshki

Multi-cohort validation of a semaphorin prognostic signature to identify an immune- excluded subtype and therapeutic sensitivity in lung adenocarcinoma.

Kenneth P. Seastedt, Amirhossein Zare, Parmida Sadat Pezeshki, Seyed Reza Salarikia et autres

e20016 Background: Semaphorins, classically implicated in axonal guidance, have increasingly recognized roles in tumor progression and immune regulation. However, their integrated prognostic significance and biological relevance in lung adenocarcinoma (LUAD) remain incompletely characterized. Methods: A retrospective multi-cohort study used TCGA-LUAD RNA-sequencing data …

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Human Endometriosis Scaffold Can Enhance Cell Seeding and Engraftment; an In Vitro and In Vivo Study

Ashkan Azimzadeh, Roxana Sahmani, Negar Mohammadi Ganjaroudi, Parmida Sadat Pezeshki et autres

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Apixaban versus enoxaparin for venous thromboembolism prophylaxis after total gastrectomy in patients with gastric cancer: a randomized controlled trial

Seyed Amir Miratashi Yazdi, Parmida Sadat Pezeshki, Mohammad Reza Zafarghandi

BACKGROUND: Patients undergoing total gastrectomy for gastric cancer are at high risk of venous thromboembolism (VTE), and enoxaparin is the current standard for prophylaxis. However, direct oral anticoagulants such as apixaban may improve adherence and patient satisfaction due to oral administration and …

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Incorporating mRNA therapeutics into biological treatments of hematologic malignancies

Jaromir Hunia, Jaromir Tomasik, Natalia Czerwik, Parmida Sadat Pezeshki et autres

The recent advancement of mRNA technology has opened new therapeutic avenues for treating hematologic malignancies, offering innovative approaches to enhance existing immunotherapies. This review examines the expanding role of in vitro transcribed (IVT)-mRNA-based platforms in hemato-oncology, focusing on key areas: monoclonal antibody …

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Tumor extracellular matrix enhances invasive gene expression of breast cancer cells in 3D patient-derived scaffolds

Parmida Sadat Pezeshki, Negar Mohammadi Ganjaroudi, Ashkan Azimzadeh, Masoumeh Majidi Zolbin et autres

Extracellular matrix (ECM) remodeling in cancer provides an essential substructure for tumor progression. We utilized patient-derived scaffolds (PDS) to model tumor ECM changes and study their impact on cell behavior. PDS were obtained from breast tumor and normal healthy breast tissue by …

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Human umbilical cord mesenchymal stem cells-derived extracellular vesicles as a therapeutic approach to ameliorate bladder injury in animal models of radiation cystitis

Parmida Sadat Pezeshki, Amir Mahboubi, Negar Mohammadi Ganjaroudi, Reza Ghalehtaki et autres

BACKGROUND: Radiation cystitis (RC) is a major complication of pelvic radiotherapy, leading to inflammation, vascular damage, and fibrosis. While mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) show promise in regenerative medicine, their therapeutic effects on RC remain unclear. This study evaluates the efficacy …

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Intermittent Ureteropelvic Junction Obstruction Can Mimic Abdominal Migraine: A Case Report and Review of the Literature

Yasaman Daryabari, Parmida Sadat Pezeshki, Negar Mohammadi Ganjaroudi, Abdol‐Mohammad Kajbafzadeh

Recurrent abdominal pain poses a diagnostic challenge in the pediatric population. Functional and structural etiologies can contribute to this condition. The organic etiologies of recurrent abdominal pain are diagnoses of exclusions and considering them as the initial diagnosis could lead to mis- …

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The role of radiotherapy in the management of metastatic rectal cancer: A narrative review on the opportunities for non-operative management and organ preservation

Reza Ghalehtaki, Parmida Sadat Pezeshki, Amirali Azimi, Fatemeh‐Sadat Tabatabaei et autres

About 20% of patients with rectal cancer present with metastatic rectal cancer (MRC). The 5-year relative survival for patients with MRC is about 15%. With emerging systemic therapies, including more effective chemotherapy regimens, immunotherapy, targeted therapies, and radiotherapy as a local option, …

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Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers.

Mahsa Keshavarz‐Fathi, Farzaneh Darbeheshti, Rangarirai Makuku, Parmida Sadat Pezeshki et autres

Background: Identifying novel diagnostic biomarkers with stable structures, such as circulating circular RNAs (circRNAs) can improve the early detection and management of BC. Herein, we conducted this study to analyze the expression profile of four circRNAs, including circCSPP1 (hsa_circ_0001806), circNRIP1 (hsa_circ_0004771), circSMAD2 …

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Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers

Mahsa Keshavarz‐Fathi, Farzaneh Darbeheshti, Rangarirai Makuku, Parmida Sadat Pezeshki et autres

Background: Identifying novel diagnostic biomarkers with stable structures, such as circRNAs can improve the early detection and management of BC.Herein, we conducted this study to analyze the expression profile of four circRNAs, including circCSPP1 (hsa_circ_0001806), circNRIP1 (hsa_circ_0004771), circSMAD2 (hsa_circ_0000847), and circFOXP1 (hsa_circ_0008234) …

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Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross‐Sectional Phase of Tehran Cohort Study

Pooria Ahmadi, Sajjad Ahmadi‐Renani, Parmida Sadat Pezeshki, Sepehr Nayebirad et autres

Background and Aims: In the current study, we aimed to identify the association between major and minor electrocardiographic abnormalities and cardiovascular risk factors. Methods: We used the Tehran cohort study baseline data, an ongoing multidisciplinary, longitudinal study designed to identify cardiovascular disease …

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Preclinical Cancer Models for the Evaluation of Immunotherapies: From Cell Lines to Animal Models

Parmida Sadat Pezeshki, Nima Rezaei

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