Olorunfemi A. Eseyin

Curcumin poly D-L lactide nanoparticles demonstrate superior antiplasmodial Efficacy and multi-target binding compared with dihydroartemisinin: Integrative in vivo and in silico analyses

Olorunfemi A. Eseyin, Aniekan Ebong, Ekarika Clement Johnson, Emmanuel O. Olorunsola et autres

The urgent rise of drug-resistant malaria underscores the need for innovative antimalarial agents with multi-targeting capabilities. Curcumin, a polyphenolic compound derived from turmeric, is known for its extensive pharmacological properties; however, its low bioavailability hinders its clinical application. This study compared the …

Nigéria, sa (code pays fourni par la source)

Repurposing sirolimus as a single and combination therapy for malaria: in silico, in vivo and pharmacokinetic studies

Bassey Asuquo Andong, Samuel Onyeka Onyechi, Ekemini Victor Etukakpan, Mfonobong Effiong Umoh et autres

Malaria remains endemic in Africa, with emerging reports indicating resistance of the causative agent, Plasmodium spp. , to Artemisinin Combination Therapies (ACT) approved for malaria treatment by the World Health Organization (WHO). This study aimed to determine the efficacy of Sirolimus, an …

Nigéria (code pays fourni par la source)

Antiplasmodial Potential of Quercetin and Its Derivatives: Molecular Docking, Synthesis and In Vivo Studies

Paschal C. Anthony, Emmanuel E. Attih, Aniekan Ebong, Ekarika C. Johnson et autres

Antimalarial drug-resistance has become a critical global issue, thereby making the search for novel and effective antimalarials imperative. This study aimed at designing, synthesising, and evaluating the antiplasmodial properties of quercetin and some of its derivatives. Forty quercetin derivatives were designed with …

Glucosyl Xanthone, d-Idopyranoside, Fatty Acid and Isoprene Derivatives as New Anti-Malarial Compounds Targeting Plasmodium Falciparum Thymidine Monophosphate Kinase (PfTMPK)

Edet Effiong Asanga, Henshaw Uchechi Okoroiwu, Uwem Okon Edet, Usenobong F. Ufot et autres

Background Chemotherapy is considered the best approach in the management of malaria pathogenesis symptomized with hyperparasitemia and oxidative stress because of free radicals’ production; however, a crucial step in the production of DNA is the reversible phosphorylation of dTMP to dTDP, which …

Nigéria, kh (code pays fourni par la source)

Isolation of a Lauryl Alcohol (1-Dodecanol) from the Antioxidant Bioactive Fractions of Justicia insularis (Acanthaceae) Leaves

Romanus A. Umoh, Edet Effiong Asanga, Paul S. Thomas, Uwemedimo Francis Umoh et autres

Background Scientific and ethnopharmacological studies have shown that Justicia insularis leaves are used in the treatment of oxidative stress, heart problems, labour pains, and dysmenorrhoea. Therefore, this study was geared towards the investigation of the antioxidant claims of this plant leaves as …

Nigéria, cn (code pays fourni par la source)

In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae)

Sheryar Afzal, Yuan Seng Wu, Aimi Syamima Abdul Manap, Ali Attiq et autres

BACKGROUND: Sansevieria trifasciata, common name, mother-in-law's tongue, is a member of the Agavaceae family. We undertook this study to evaluate the cytotoxicity of S. trifasciata leaf extract against two cancer cell lines as well as its antibacterial activities against six bacterial strains. …

sa, my, Nigéria (code pays fourni par la source)

New Perspectives on the Therapeutic Potentials of Bioactive Compounds from Curcuma longa : Targeting COX-1 & 2, PDE-4B, and Antioxidant Enzymes to Counteract Oxidative Stress and Inflammation

Edet Effiong Asanga, Akaninyene Joseph, Ekementeabasi Aniebo Umoh, Chinedum Martins Ekeleme et autres

Background Inflammations, oxidative stress, and pains underlie the pathogenesis of non-communicable diseases (NCDs) like respiratory disorders and cancer; however, they are scientifically treated with Curcuma longa. Therefore, the pharmacological screening (antioxidant, anti-inflammatory, and analgesic) of the plant's rhizome, isolation and characterization of …

Nigéria, cn (code pays fourni par la source)

Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Edet Effiong Asanga, Ndifreke Daniel Ekpo, Affiong Asuquo Edeke, Chinedum Martins Ekeleme et autres

BACKGROUND: Chemotherapies target the PfEMP-1 and PfPKG proteins in Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the disease's high fatality rate. This work identified the phytochemical components of Nauclea latifolia roots and docked the chemical compounds against …

Nigéria (code pays fourni par la source)

Drug Repurposing for malaria therapy: An in silico study

Olorunfemi A. Eseyin, Bassey Asuquo Andong, Samuel Onyeka Onyechi, Ekemini Victor Etukakpan et autres

Drug Repurposing for malaria therapy: An in silico study Malaria, an endemic disease in Africa, is caused by five protozoan parasite species, with Plasmodium falciparum causing the most severe infections. In the year 2022, over 233 million malaria cases were recorded in …

Nigéria, sa, Libye (code pays fourni par la source)

Drug Repurposing for malaria therapy: An in silico study

Olorunfemi A. Eseyin, Bassey Asuquo Andong, Samuel Onyeka Onyechi, Ekemini Victor Etukakpan et autres

Drug Repurposing for malaria therapy: An in silico study Malaria, an endemic disease in Africa, is caused by five protozoan parasite species, with Plasmodium falciparum causing the most severe infections. In the year 2022, over 233 million malaria cases were recorded in …

Nigéria, sa, Libye (code pays fourni par la source)

Binding affinities of chalcones, flavonols, sterols, sapogenins and carbazoles downloaded from PubChem on antimalaria targets

Olorunfemi A. Eseyin, Bassey Asuquo Andong, Samuel Onyeka Onyechi, Ekemini Victor Etukakpan et autres

Malaria remains a persistent health challenge in Africa, particularly in Nigeria, where it accounts for the highest mortality rates. The increasing resistance of Plasmodium parasites to conventional antimalarial drugs necessitates the exploration of novel therapeutic agents. This study focuses on the in …

Nigéria, sa, Libye (code pays fourni par la source)

Binding affinities of chalcones, flavonols, sterols, sapogenins and carbazoles downloaded from PubChem on antimalaria targets

Olorunfemi A. Eseyin, Bassey Asuquo Andong, Samuel Onyeka Onyechi, Ekemini Victor Etukakpan et autres

Malaria remains a persistent health challenge in Africa, particularly in Nigeria, where it accounts for the highest mortality rates. The increasing resistance of Plasmodium parasites to conventional antimalarial drugs necessitates the exploration of novel therapeutic agents. This study focuses on the in …

Nigéria, sa, Libye (code pays fourni par la source)