Glucosyl Xanthone, d-Idopyranoside, Fatty Acid and Isoprene Derivatives as New Anti-Malarial Compounds Targeting Plasmodium Falciparum Thymidine Monophosphate Kinase (PfTMPK)
Rattachement africain : Nigéria, kh. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Chemotherapy is considered the best approach in the management of malaria pathogenesis symptomized with hyperparasitemia and oxidative stress because of free radicals’ production; however, a crucial step in the production of DNA is the reversible phosphorylation of dTMP to dTDP, which is catalyzed by Plasmodium falciparum thymidylate kinase. Ethnopharmacologically and scientifically, Mangifera indica is used in the treatment of malaria, thereby necessitating antiplasmodial and antioxidant screening of the plant extract, as well as its in silico profiling to unravel the pharmacological and docking potentials of its bioactive compounds against thymidylate kinase. Methods The collection of the Mangifera indica stem bark, extract preparation, in vivo antiplasmodial assay, in vitro antioxidant assay, retrieval of Plasmodium falciparum thymidylate kinase, and gas chromatography-mass spectrophotometry (GC-MS) were done using standard protocols. The SwissADME tool was used in the prediction of the physicochemical, drug-likeness, and pharmacokinetic properties, whereas molecular docking analysis was done with the MCULE tool. Results The GC-MS profiling revealed mangiferin, d-idopyranoside, lauric acid, fatty acid, isoprene derivatives, etc; these compounds contributed immensely to the plant's antioxidant and antiplasmodial (87.71%) potentials. Also, the compounds (55.7%) successfully docked the active sites of thymidylate kinase; 72.1% and 57.4% revealed high rates of gastrointestinal tract (GIT) absorption and distribution in the interstitial tissues, respectively, whereas 98.4% were not substrates of permeation glycoprotein. However, the % non-inhibition of CYP1A2, CYP2C19, CYP2C9, CYP2D6, and CYP3A4 were 45.9, 98.4, 67.2, 95.1, and 98.4, respectively, while drug-likeness revealed 100% Lipinski's compliance. Conclusion The observed antiplasmodial, antioxidant, and pharmacological properties could be due to the presence of the glucosyl xanthone, idopyranoside, fatty acid, and isoprene derivatives.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Glucosyl Xanthone, d-Idopyranoside, Fatty Acid and Isoprene Derivatives as New Anti-Malarial Compounds Targeting <i>Plasmodium Falciparum</i> Thymidine Monophosphate Kinase (PfTMPK)
- Date Crossref
- 01/04/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Arthur Jarvis University Department of Biochemistry Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Health Science Department of Medical Laboratory Science Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
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David Umahi Federal University of Health Sciences Uburu Nigéria (code pays fourni par la source)Université ou école supérieure
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Akwa Ibom State University Department of Biochemistry Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Olusegun Agagu University of Science and Technology Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Uyo Department of Pharmacology and Toxicology University of Uyo, Nigéria (code pays fourni par la source)Université ou école supérieure
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Faculty of Science Department of Biosciences and Biotechnology Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Biochemistry — Arthur Jarvis University (Nigéria), Department of Medical Laboratory Science — University of Health Science (Nigéria) et David Umahi Federal University of Health Sciences Uburu (Nigéria), avec 5 autres affiliations. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.