Arie Oliven

Three-Year Outcomes of Proximal Hypoglossal Nerve Stimulation in OSA

A. Schwartz, Ofer Jacobowitz, Samuel A. Mickelson, Mitchell B. Miller et autres

BACKGROUND: Targeted proximal hypoglossal nerve stimulation was shown to improve sleep-disordered breathing, sleep architecture, and quality of life (QOL) with a favorable safety profile over 1 year in the Targeted Hypoglossal Stimulation 3 (THN3) randomized controlled trial. Herein, THN3 proximal hypoglossal nerve …

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Neurophysiologic tongue protrusion characteristics$ in obstructive sleep apnea: A comparative study

Ron Oliven, Arie Oliven, Mostafa Somri, Emília Hardak et autres

The essential role of upper airway muscles in maintaining patency has led to the hypothesis that alterations in tongue muscle properties may contribute to the development of obstructive sleep apnea (OSA). Prior studies comparing the mechanical characteristics of tongue muscles in OSA …

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Three-year Efficacy of Proximal and Distal Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea Was Comparable in the THN3 and STAR Trials

Alan R. Schwartz, Ofer Jacobowitz, S.A. Mickelson, M.B. Miller et autres

Abstract RATIONALE: Phase III trials of proximal and distal hypoglossal nerve stimulation (pHGNS and dHGNS) for obstructive sleep apnea (OSA), THN3 and STAR, respectively, enrolled disparate cohorts that received different versions of HGNS. Nonetheless, previously reported one-year outcome statistics were remarkably similar. …

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0761 Detailed Three-Year Effects of Proximal Targeted Hypoglossal Nerve Stimulation on Apnea-Hypopnea Index in Moderate to Severe Obstructive Sleep Apnea

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, Mitchell D. Miller et autres

Abstract Introduction Proximal hypoglossal nerve stimulation (pHGNS) has been shown in the THN3 randomized, controlled trial to produce durable three-year improvements in quality of life, oxygenation, and sleep-disordered breathing (Apnea-Hypopnea Index, AHI) in moderate to severe obstructive sleep apnea (OSA). Detailed AHI …

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Differential neuromotor control of the vertical and longitudinal genioglossus muscle fibers: An overlooked tongue retractor

Ron Oliven, Arie Oliven, Mostafa Somri, Alan R. Schwartz et autres

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Proximal Hypoglossal Nerve Stimulation Improves Self-reported Frequency and Severity of Snoring in Moderate to Severe Obstructive Sleep Apnea

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, M.B. Miller et autres

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0599 Effects of Proximal HGN Stimulation in HTN Subjects with Moderate to Severe OSA: A 5-Year Analysis of the THN3 RCT

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, Mitchell D. Miller et autres

Abstract Introduction Hypoglossal nerve stimulation (HGNS) improves sleep-disordered breathing (SDB), oxygenation, and quality of life (QOL) in obstructive sleep apnea (OSA), but to date, has not been shown to improve cardiovascular outcomes. The THN3 randomized, controlled trial of proximal HGNS included subjects …

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Three-year outcomes of Targeted Hypoglossal Nerve Stimulation randomized controlled trial (THN3) for Obstructive Sleep Apnea

Ofer Jacobowitz, Joachim Theodor Maurer, Samuel Mickelson, Mark D. Miller et autres

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0453 3-Year Outcomes of Proximal Hypoglossal Nerve Stimulation in the THN3 Controlled Trial

Alan R. Schwartz, Ofer Jacobowitz, Samuel Mickelson, Mitchell D. Miller et autres

Abstract Introduction The THN3 randomized, controlled trial of moderate to severe obstructive sleep apnea (OSA) showed that proximal (“targeted”) hypoglossal nerve stimulation (HGNS) safely improved sleep-disordered breathing (SDB) and quality of life (QOL) through 11 months of treatment. Outcomes of subjects receiving …

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Sustained Therapeutic Benefits for 3 Years in the THN3 Randomized, Controlled Trial of Targeted Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea

Joachim Theodor Maurer, Ofer Jacobowitz, A. Samuel Mickelson, B. M. Miller et autres

Rationale The THN3 randomized, controlled trial demonstrated that targeted hypoglossal nerve stimulation (THN) was associated with substantial improvement in sleep-disordered breathing over 11 months of therapy in moderate to severe obstructive sleep apnea (OSA) with a favorable safety profile. Subjects receiving THN …

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3-Jahres-Ergebnisse der prospektiv randomisiert kontrollierten THN3-Studie zur kontinuierlichen, gezielten Hypoglossusstimulation zur Behandlung der obstruktiven Schlafapnoe

Joachim Theodor Maurer, Ofer Jacobowitz, A. Samuel Mickelson, B. Mitchell Miller et autres

Einleitung In der randomisiert kontrollierten THN3-Studie führte die gezielte Hypoglossusstimulation (THN) nach 11 Monaten Therapie bei geringer Morbidität zu einer substanziellen Verbesserung der obstruktiven Schlafapnoe (OSA), insbesondere zeigte sich eine signifikante überlegenheit gegenüber einer Kontrollgruppe mit inaktiver Therapie. Hier werden Sicherheit und …

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Targeted Hypoglossal Nerve Stimulation for Patients With Obstructive Sleep Apnea

Alan R. Schwartz, Ofer Jacobowitz, David W. Eisele, Samuel A. Mickelson et autres

Importance: Evidence is lacking from randomized clinical trials of hypoglossal nerve stimulation in obstructive sleep apnea (OSA). Objective: To evaluate the safety and effectiveness of targeted hypoglossal nerve stimulation (THN) of the proximal hypoglossal nerve in patients with OSA. Design, Setting, and …

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