Arto Yuwono Soeroto

Is targeted next generation sequencing for drug-resistant tuberculosis feasible in a high-burden setting: a qualitative study from Indonesia

Salma N. Annisa, Almira Alifia, Alamanda Larasmanah, Nurlaila S. Ramadhani et autres

OBJECTIVES: Targeted next-generation sequencing (tNGS) offers promise in the rapid detection of drug-resistant tuberculosis (DR-TB) directly from sputum. While pilot studies on tNGS are emerging, there is limited empirical qualitative evidence on tNGS implementation. This study, therefore, aimed to explore the experiences …

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Characteristics of Primary and acquired multidrug-resistant tuberculosis patients in West Java, Indonesia

Prayudi Santoso, Alya Putri Khairani, Eppy Buchori Aristiady, Lidya Chaidir et autres

Objectives: The increasing incidence of primary multidrug-resistant tuberculosis (MDR-TB) creates a new burden in national tuberculosis (TB) control. Understanding the characteristics of primary MDR-TB aids in predicting its spread. This study aimed to determine the differences in characteristics of primary and acquired …

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Pretreatment out-of-pocket costs for people with drug-resistant tuberculosis in Bandung, Indonesia

Bony Wiem Lestari, Silvi Indriani, Adriana Viola Miranda, Dyah Ayu Nur Safira et autres

BACKGROUND: People with drug-resistant tuberculosis (DR-TB) experience multiple visits to healthcare providers before DR-TB diagnosis and treatment. Our study aimed to quantify pretreatment direct costs and factors associated with higher costs among people with DR-TB. METHODS: Our cross-sectional study aimed to recruit …

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Targeted next-generation sequencing for direct drug-resistant tuberculosis detection in sputum samples in Indonesia: an implementation study (2024–25)

Bony Wiem Lestari, Rifky Waluyajati Rachman, Rahmah Aulia Zahra, Alamanda Larasmanah et autres

Background: The availability of targeted Next Generation Sequencing (tNGS) for drug-resistant tuberculosis (DRTB) is a major advance in TB diagnostics, but its optimal implementation, yield, and cost in high TB-incidence settings remain unclear. We aimed to evaluate tNGS in relation to laboratory …

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RISK6 as a Translational Host Transcriptomic Signature for Tuberculosis Diagnosis, Treatment Monitoring, and Risk Stratification

Chrispian Mamudi, Purnamawati -, Panca Andana, Prayudi Santoso et autres

Tuberculosis (TB) remains a leading cause of infectious mortality worldwide, reflecting persistent gaps in diagnosis, risk stratification, and treatment monitoring. Host RNA transcriptomic signatures have emerged as promising tools for capturing dynamic immune responses across the TB disease spectrum. Among these, the …

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Factors Predicting successful treatment outcome with novel BPaLM/BPaL regimen in individuals with drug-resistant tuberculosis: Experience From Indonesia

Arto Yuwono Soeroto, Aga Purwiga, Hendarsyah Suryadinata, Bachti Alisjahbana et autres

BACKGROUND AND AIMS: Drug-resistant tuberculosis (DR-TB) poses a serious challenge in Indonesia, with treatment success rates of only 50%. The BPaLM/BPaL regimen represents the latest therapeutic approach, offering shorter duration, minimal side effects, and treatment success rates of 84-90%. An operational research …

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RISK6 as a Translational Host Transcriptomic Signature for Tuberculosis Diagnosis, Treatment Monitoring, and Risk Stratification

Chrispian Mamudi, Arto Yuwono Soeroto, Lidya Chaidir, Purnamawati - et autres

Tuberculosis (TB) remains a leading cause of infectious mortality worldwide, reflecting persistent gaps in diagnosis, risk stratification, and treatment monitoring. Host RNA transcriptomic signatures have emerged as promising tools for capturing dynamic im-mune responses across the TB disease spectrum. Among these, the …

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Use of Targeted Next-Generation Sequencing for Direct Drug-Resistant Tuberculosis Detection on Sputum: An Implementation Study in Indonesia

Bony Wiem Lestari, Rifky Waluyajati Rachman, Rahmah Aulia Zahra, Alamanda Larasmanah et autres

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Machine-Learning Screening of Pulmonary Tuberculosis from Digital Stethoscope Lung Sounds: A Preliminary Study with Subject-Level Validation

Husneni Mukhtar, Bony Wiem Lestari, Nabila Nur Fadilah Hidayat, Sonya Alexandra et autres

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Chronic Respiratory Symptoms among TB Survivors in a High-TB Burden Setting in Indonesia: A Preliminary Study

Intan Mauli Warma Dewi, Raden Nabilah Putri Fauziyyah, Iceu Dimas Kulsum, Bony Wiem Lestari et autres

Background: Tuberculosis (TB) affects over 10 million people worldwide and causes more than 1.4 million deaths in 2019. Despite improvements in TB treatment, many TB survivors experience ongoing health problems. Post-TB lung disease (PTLD) affects 30-60% of treated patients, leading to chronic …

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Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia

Htin Lin Aung, Lidya Chaidir, Dian Ayu Eka Pitaloka, Narender Kumar et autres

OBJECTIVE: This study evaluated drug resistance profiles of Mycobacterium tuberculosis (Mtb) isolates in West Java, Indonesia through phenotypic and genomic approaches. METHODS: We performed phenotypic drug-susceptibility testing (DST), coupled with whole-genome sequencing (WGS) of 142 Mtb isolates identified as RIF-R (Rifampicin resistant) …

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High Rates of Mortality During Drug-Resistant Tuberculosis Treatment Among Individuals With Diabetes Mellitus and Low Body Mass Index

Lara D Veeken, Iceu Dimas Kulsum, Bony Wiem Lestari, Prayudi Santoso et autres

Abstract Background Diabetes is a risk factor for mortality during rifampicin-resistant tuberculosis (RR-TB) treatment, but whether its impact differs by nutritional status is unknown. We estimated the effect of diabetes and its interaction with low body mass index (BMI) (ie, <18.5 kg/m2) …

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