High Rates of Mortality During Drug-Resistant Tuberculosis Treatment Among Individuals With Diabetes Mellitus and Low Body Mass Index
Rattachement africain : nl, us, id, kh, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Diabetes is a risk factor for mortality during rifampicin-resistant tuberculosis (RR-TB) treatment, but whether its impact differs by nutritional status is unknown. We estimated the effect of diabetes and its interaction with low body mass index (BMI) (ie, <18.5 kg/m2) on all-cause mortality during treatment of RR-TB. Methods We used medical record data of adults treated for RR-TB in Indonesia between March 2020 and May 2022. Diabetes was defined as glycated hemoglobin ≥6.5% or prior diabetes diagnosis by healthcare providers. Cox proportional hazards regression was used to estimate the hazard rates of mortality during treatment comparing those with and without diabetes. Multiplicative and additive interactions were evaluated to determine if the effect of diabetes on mortality during treatment was moderated by BMI status. Results Among 345 individuals (57% male, 1.7% with human immunodeficiency virus, 59% with BMI <18.5 kg/m2), 96 (28%) had diabetes and 62 (18%) died. Adjusting for confounders, the hazard rates of mortality during treatment were higher among those with diabetes (adjusted hazard rate ratio [aHR], 2.05 [95% CI, 1.17–3.58]) or those with BMI <18.5 kg/m2 (aHR, 2.33 [95% CI, 1.28–4.21]). No significant multiplicative nor additive interaction was detected, but the hazard rates of mortality were highest among those with diabetes and BMI <18.5 kg/m2 (aHR, 7.14 [95% CI, 2.71–18.82]) compared to those without diabetes and BMI ≥18.5 kg/m2. Conclusions Having diabetes doubled the risk of mortality during RR-TB treatment. Highest mortality rates were observed among individuals with combined diabetes and low BMI.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- High Rates of Mortality During Drug-Resistant Tuberculosis Treatment Among Individuals With Diabetes Mellitus and Low Body Mass Index
- Date Crossref
- 25/06/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center Department of Internal Medicine and Radboud Community for Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Radboud University Medical Center pays non établi dans la noticeOrganisme public
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Radboud Institute for Molecular Life Sciences pays non établi dans la noticeStructure de recherche
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Dr. Hasan Sadikin General Hospital pays non établi dans la noticeÉtablissement de santé
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Padjadjaran University pays non établi dans la noticeUniversité ou école supérieure
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Stanford University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Angkor Hospital for Children pays non établi dans la noticeÉtablissement de santé
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University of Oxford Nuffield Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Research Center for Care and Control of Infectious Diseases Tuberculosis Working Group pays non établi dans la noticeStructure de recherche
Radboud University Nijmegen, Department of Internal Medicine and Radboud Community for Infectious Diseases — University Medical Center et Radboud University Medical Center, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.