Taejeong Ha

In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration

Hyungwoo Lee, Hyoik Jang, Jae‐Byoung Chae, Hyo Kyung Lee et autres

Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age‑related macular degeneration (AMD), lead to progressive vision loss through photoreceptor degeneration; RP begins with the gradual loss of peripheral rods, whereas AMD causes central‑vision loss mainly because macular cones and parafoveal rods …

kr, us (code pays fourni par la source)

Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium

You-Joung Kim, Sooyeon Park, Taejeong Ha, Seungbeom Kim et autres

In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina.The RPE takes up retinol (ROL) to be dehydrogenated and isomerized to 11-cis-retinaldehyde (11-cis-RAL), which is a functional photopigment in mammalian photoreceptors.As excessive ROL is toxic, the …

kr, cn (code pays fourni par la source)

Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity

Le Dai, Soyeon Lim, Kwang Wook Min, Jun Woo Park et autres

The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, …

kr, us (code pays fourni par la source)

mTORC1 accelerates retinal development via the immunoproteasome

Ji-heon Choi, Hong Seok Jo, Soyeon Lim, Hyoung-Tai Kim et autres

The numbers and types of cells constituting vertebrate neural tissues are determined by cellular mechanisms that couple neurogenesis to the proliferation of neural progenitor cells. Here we identified a role of mammalian target of rapamycin complex 1 (mTORC1) in the development of …

kr (code pays fourni par la source)

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina

Taejeong Ha, Kyeong Hwan Moon, Le Dai, Jun Hatakeyama et autres

Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal progenitor cells (RPCs) by eliminating …

kr, jp (code pays fourni par la source)

The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song et autres

The visual responses of vertebrates are sensitive to the overall composition of retinal interneurons including amacrine cells, which tune the activity of the retinal circuitry. The expression of Paired-homeobox 6 (PAX6) is regulated by multiple cis-DNA elements including the intronic α-enhancer, which …

kr, jp, us (code pays fourni par la source)

Author response: The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song et autres

The retina is a light-sensitive layer of tissue that lines the inside of the eye. This tissue is highly organized and comprises a variety of different nerve cells, including amacrine cells. Together, these cells process incoming light and then trigger electrical signals …

kr, jp, us (code pays fourni par la source)

Investigation of functional Notch signal sending cells in developing mouse retina = 생쥐 망막에서 Notch 신호전달 유발 세포에 관한 연구

Taejeong Ha, 하태정