Shū Kobayashi

Sustainable and Atom-Economical Continuous-Flow Synthesis of Iguratimod via Robust Heterogeneous N -Heterocyclic Carbene Catalysis

Shunsuke Mouri, Tetsu Tsubogo, Yuki Nakagawa, Toshiya Asakawa et autres

Abstract A robust, heterogeneous N-heterocyclic carbene catalytic flow system was developed for the sustainable synthesis of 3-aminochromones via an intramolecular Stetter-type reaction. By identifying and suppressing a critical benzylic leaching pathway during catalyst preparation, the immobilized triazolium species achieved unprecedented long-term stability …

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Association Between Weekly Amount of Home-Visit Rehabilitation and Changes in Activities of Daily Living: A Retrospective Cohort Study Using Home-Visiting Nursing Station Records

Hayato Tarumi, Kazuaki Uda, Jun Komiyama, Masahiko Hasegawa et autres

Objective To examine the association between average weekly minutes of home-visit rehabilitation (HR) and 6-month changes in activities of daily living (ADL) for older adults. Design Retrospective cohort study using anonymized electronic health record data. Setting A total of 1525 home-visit nursing …

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Rendering Solubility Irrelevant: Interfacial Cooperative Catalysis by La2NiO4 Enables Aquachemical Knoevenagel Condensation

Sota Iwasaki, Taku Kitanosono, Yasuhiro Yamashita, Shū Kobayashi

Abstract Achieving carbon–carbon bond formation in water without relying on substrate solubility remains a fundamental challenge in sustainable chemistry. Herein, we report an “aquachemical” Knoevenagel condensation catalyzed by a layered lanthanum nickelate (La2NiO4) under interfacial (Type IIIc) conditions. The reaction proceeds efficiently …

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Outer-Sphere Asymmetric Mukaiyama Aldol Reactions in Water at Micellar Interfaces

Taku Kitanosono, Shū Kobayashi, Lei Zhu, Pengyu Xu et autres

Abstract An asymmetric Mukaiyama aldol reaction operating at deliberately organized aqueous interfaces is described. The reaction proceeds through an outer-sphere mechanism, as established by prior computational studies on related iron(II)-based catalytic systems, enabling enhanced stereocontrol together with a unique metal-dependent syn/anti diastereodivergence …

Heterogeneous Catalysis for Dehydrative Condensation of Carboxylic Acids and Amines Bearing Basic Functionalities for Continuous-Flow Synthesis of Flecainide

Kota Takeno, Haruro Ishitani, Shū Kobayashi

Abstract In acid-catalyzed dehydrative amidation, catalysts must efficiently activate carboxylic acids despite the competitive presence of basic amine substrates. Substrates bearing diverse functional groups—ubiquitous in pharmaceutical synthesis—demand high levels of chemoselective activation. Continuous-flow systems utilizing packed-bed heterogeneous catalysts offer superior contact efficiency, …

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Flow fine synthesis with heterogeneous catalysts: A Seven-Year Update

Koichiro Masuda, Shun‐ya Onozawa, Tomohiro Ichitsuka, Kwihwan Kobayashi et autres

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Selective Nitrone Synthesis via Cascade Hydrogenative Coupling of Nitro Compounds and Aldehydes Catalyzed by Single-Atom Platinum on N,P-Doped Carbon

Taisei Senzaki, Tomohiro Yasukawa, Yasuhiro Yamashita, Tei Maki et autres

Single-atom catalysts have emerged as powerful platforms for selective hydrogenation reactions owing to their well-regulated active sites; however, their unique reactivity in cascade hydrogenation processes remains relatively unexplored. Herein, we report that a single-atom platinum catalyst supported on N,P-doped carbon efficiently catalyzes …

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Selective Continuous‐Flow Syntheses of 1,2‐Diols From Alkenes by Utilizing a Dual Functionality of Titanium Silicalite‐1 Catalyst in the Presence of Hydrogen Peroxide Without Carboxylic Acids

Yoshihiro Kon, Takuya Nakashima, Hiroki Nagashima, Yoshiki Makino et autres

Selective syntheses of 1,2‐diols from alkenes have traditionally relied on carboxylic acids and various oxidants, which often co‐produce hazardous byproducts. This report describes a simple, carboxylic‐acid‐free method to produce various aliphatic and cyclic diols from their corresponding alkenes in 51–96% isolated yields …

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Association Between Weekly Amount of Home-Visit Rehabilitation and Changes in Activities of Daily Living: A Retrospective Cohort Study Using Home-Visiting Nursing Station Records

Hayato Tarumi, Kazuaki Uda, Jun Komiyama, Masahiko Hasegawa et autres

OBJECTIVE: To examine the association between average weekly minutes of home-visit rehabilitation (HR) and 6-month changes in activities of daily living (ADL) for older adults. DESIGN: Retrospective cohort study using anonymized electronic health record data. SETTING: A total of 1525 home-visit nursing …

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Polystyrene-supported aminobenzenesulfonic acids as bifunctional heterogeneous catalysts for the synthesis of isoxazoline skeletons

Kai Takizawa, Takuma Ishihara, Shinki Tani, Yusuke Hamada et autres

The isoxazoline skeleton is a pivotal structural motif in pharmaceuticals and agrochemicals, necessitating the development of efficient synthetic methodologies.

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Kinetics-Guided Multistep Continuous Synthesis of Quinizarin Derivatives via Evaporation-Assisted CSTR–PFR Cascade

Hiroyuki Miyamura, Shusaku Asano, Ryosuke Kajiyama, Masakazu Takata et autres

Space-velocity-governed chemoselective pseudo-oxidation: a convergent flow platform for the synthesis of evocalcet

Tetsu Tsubogo, Rio Sakamoto, Haruro Ishitani, Shū Kobayashi

), establishing a fundamental descriptor of flow intensity that operates independently of simple concentration or reaction-slowing effects. The integration of these three hydrogen-mediated transformations enabled the formation of the evocalcet ester in 79% yield, followed by hydrolysis to furnish evocalcet in high …

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