Sustainable and Atom-Economical Continuous-Flow Synthesis of Iguratimod via Robust Heterogeneous N -Heterocyclic Carbene Catalysis
Shunsuke Mouri, Tetsu Tsubogo, Yuki Nakagawa, Toshiya Asakawa et autres
Abstract A robust, heterogeneous N-heterocyclic carbene catalytic flow system was developed for the sustainable synthesis of 3-aminochromones via an intramolecular Stetter-type reaction. By identifying and suppressing a critical benzylic leaching pathway during catalyst preparation, the immobilized triazolium species achieved unprecedented long-term stability …
jp (code pays fourni par la source)
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ACS Sustainable Chemistry & Engineering