Domenico Frondizi

Insights From the Disabled Advanced Medical Assistance Project

Nicola Panocchia, Eluisa Lo Presti, Carla Benassai, Elisabetta Berni et autres

Importance: Equitable access to health care for persons with disabilities is not always guaranteed, despite the internationally recognized right to health care. Architectural, organizational, and cultural barriers, along with a lack of specialized skills among health care professionals, limit access to care, …

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A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial

Flavia Lucia Lombardo, Stefania Spila Alegiani, Flávia Mayer, Marta Cipriani et autres

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant improvements in therapeutic options for ALS patients in recent years. Currently, there is no cure for …

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Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis

Maurizio Angelo Leone, Maurizio Gelati, Daniela Celeste Profico, Claudio Gobbi et autres

We report the analysis of 1 year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation phase I study (ClinicalTrials.gov: NCT03282760, EudraCT2015-004855-37) to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural …

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Persistent hemiplegia with normal intraoperative neurophysiological monitoring in supratentorial neurosurgery: a case report and review of literature

Giuseppe Stipa, Marco Muti, Alessandro Ciampini, Domenico Frondizi et autres

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Foetal Allogeneic Intracerebroventricular Neural Stem Cell Transplantation in People with Secondary Progressive Multiple Sclerosis: A phase I dose-escalation clinical trial

Maurizio Angelo Leone, Maurizio Gelati, DC Profico, C Conti et autres

ABSTRACT Background Advanced cell therapeutics are emerging as potentially effective treatments for chronic neurological diseases, including secondary progressive multiple sclerosis (SPMS). Here we report the results of a phase I trial in which good manufacturing practice-grade foetal allogeneic human neural stem cells …

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A Combined One-Staged Robot-Assisted Sacral Chordoma Resection

Melina Castiglione, Carlo A. Conti, Domenico Frondizi, Emanuele Cottini et autres

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The Effect of Mozart's Music in Severe Epilepsy: Functional and Morphological Features.

Chiara Bedetti, Massimo Principi, Antonio Di Renzo, Marco Muti et autres

Music is a very important factor in everyday life, involving mood, emotions and memories. The effect of music on the brain is very debated. Certainly, music activates a complex network of neurones in auditory areas, mesolimbic areas, cerebellum and multisensory areas. In …

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Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome

Letizia Mazzini, Maurizio Gelati, Daniela Celeste Profico, Gianni Sorarú et autres

The main objective of this phase I trial was to assess the feasibility and safety of microtransplanting human neural stem cell (hNSC) lines into the spinal cord of patients with amyotrophic lateral sclerosis (ALS). Eighteen patients with a definite diagnosis of ALS …

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Mozart's music and multidrug-resistant epilepsy: a potential EEG index of therapeutic effectiveness.

Chiara Bedetti, Patrizia D’Alessandro, Massimo Piccirilli, Moreno Marchiafava et autres

Multidrug-resistant epilepsy is a pathological condition that affects approximately one-third of patients with epilepsy, especially those with associated intellectual disabilities. Several non-pharmacological interventions have been proposed to improve quality of life of these patients. In particular, Mozart's sonata for two pianos in …

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63. Guillain-Barrè syndrome with marked pleocytosis in the cerebrospinal fluid: A case report

Giuseppe Stipa, Sandro Carletti, Domenico Frondizi, C. Fanelli et autres

55. Minimally invasive lateral transpsoas approach: Comorbidity in our cases

Giuseppe Stipa, Domenico Frondizi, Carmine Giuseppe Fanelli, David G. Gobbi et autres

33. A rare case of Guillain–Barre’ syndrome and pseudotumor cerebri, with normal cerebrospinal fluid protein

Giuseppe Stipa, Stefano Caproni, Elisa Moschini, A. Sensidoni et autres