Enrico Mario Cassina

Redefining the concept of resectability in the landscape of perioperative treatments for lung cancer

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Jessica Dell’Agosto et autres

Resectability in non-small cell lung cancer (NSCLC) is shifting from a purely anatomic and surgical concept, based on technical feasibility of an R0 resection, to an integrated, multidisciplinary determination that incorporates tumor biology, expected benefit from perioperative systemic therapy and operative risk. …

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Beyond survival: Pain as the main determinant of long-term quality of life after thoracic trauma surgery

Federico Raveglia, Sara Degiovanni, Luca Bertolaccini, Andrea Cara et autres

BACKGROUND Thoracic trauma is a major cause of trauma-related morbidity and mortality, often resulting from blunt mechanisms. While advances in acute management have improved short-term outcomes, long-term results-particularly health-related quality of life (QoL) after chest wall surgery-remain poorly defined. Identifying factors influencing …

Diagnostic and therapeutic approach to neuroendocrine lung tumours: a narrative review

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Lidia Libretti et autres

Background and Objective: Lung neuroendocrine tumours (NETs) comprise a diverse and heterogeneous group of neoplasms, characterized by wide variation in growth rates, metastatic potential, molecular profiles and therapeutic susceptibilities. This review summarises current diagnostic strategies and therapeutic approaches to pulmonary NETs, offering …

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The Role of Immunotherapy in Resectable Non-Small Cell Lung Cancer

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Lidia Libretti et autres

The advent of immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 has transformed the therapeutic landscape of advanced non-small cell lung cancer (NSCLC), and recent clinical trials have extended their application to resectable disease. Multiple randomized phase III trials have demonstrated …

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Chest Wall Resection and Reconstruction Following Cancer

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Lidia Libretti et autres

The chest wall represents a complex musculoskeletal structure that provides protection to intrathoracic organs, mechanical support for respiration, and mobility for the upper limbs. Neoplastic diseases of the chest wall encompass a heterogeneous group of benign and malignant lesions, which may be …

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Is There a Risk of Recurrence That Would Discourage Sympathicotomy for Hyperhidrosis in Minors?

Sara Degiovanni, Francesco Petrella, Ugo Cioffi, Angelo Guttadauro et autres

Background/Objectives: Primary palmar hyperhidrosis (PPH) is a socially debilitating condition that often begins in adolescence. Although sympathicotomy is a low-risk procedure, there are conflicting opinions about the optimal time for surgery: some recommend it at onset in adolescence, while others are cautious …

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Pulmonary Carcinoids: Diagnostic and Therapeutic Approach

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Lidia Libretti et autres

Pulmonary carcinoids (PCs) are rare tumors, with an incidence ranging from 0.2 to 2 cases per 100,000 population per year. They account for 1-2% of all invasive pulmonary malignancies and represent approximately one-fourth to one-third of all well-differentiated neuroendocrine tumors (NETs) in …

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Pulmonary Carcinoids: Diagnostic and Therapeutic Approach

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Lidia Libretti et autres

Pulmonary carcinoids (PCs) are rare tumors, with an incidence ranging from 0.2 to 2 cases per 100,000 population per year. They account for 1–2% of all invasive pulmonary malignancies and represent approximately one-fourth to one-third of all well-differentiated neuroendocrine tumors (NETs) in …

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Clinical Impact of Vaping

Francesco Petrella, Paola Faverio, Andrea Cara, Enrico Mario Cassina et autres

The term 'vaping' refers to the use of electronic cigarettes or other devices to inhale a variety of heated and aerosolized substances. Vaping has been promoted as a less harmful and potentially oncogenic alternative to nicotine cigarettes, particularly to help heavy smokers …

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Perioperative Strategies in Resectable Non-Squamous Non-Small Cell Lung Cancer with EGFR Mutations and ALK Rearrangement

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Sara Degiovanni et autres

Lung cancer is the leading cause of cancer-related death worldwide, ranking first among men and second among women for both incidence and mortality. Surgery remains the primary treatment for early-stage, resectable non-small cell lung cancer (NSCLC), encompassing stages I and selected cases …

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Sympathetic chain reconstruction after failed sympathectomy for hyperhidrosis in regenerative medicine: a narrative review

Francesco Petrella, Federico Raveglia, Andrea Cara, Enrico Mario Cassina et autres

Hyperhidrosis is a pathologic condition characterized by abnormal sweating that is greater than normally needed for proper thermoregulation. Surgical therapy remains the only effective treatment for a definitive cure of idiopathic focal hyperhidrosis, although some controversies still exist regarding the best operation. …

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Is There a Pediatric Role for the General Thoracic Surgeon in a General Hospital? A 22-Year Single-Center Experience

Francesco Petrella, Sara Degiovanni, Federico Raveglia, Andrea Cara et autres

Background: Although general thoracic surgery is usually focused on adult patients, there are some settings of pediatric diseases which can benefit from thoracic surgical procedures. In this study, we retrospectively reviewed the contribution of general thoracic surgeons to pediatric patients in a …

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