Chuan Ping Tan

PAARH suppresses Kupffer cell phagocytosis to promote tumor liver metastasis by upregulating CD47

Wenchuan Li, Yunyu Wei, Rongzhou Lu, Gaoxiong Tan et autres

Metastasis is the primary cause of cancer-related mortality, with the liver being a common metastatic target organ for multiple malignancies. Kupffer cells (KCs), the liver-resident macrophages, play a crucial role in suppressing liver metastasis by phagocytosing disseminated tumor cells. However, the molecules …

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Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway

Xianjian Wu, Ruifeng Liang, Guoman Liu, Quan Fang et autres

Objective: Peptide-encoding roles of lncRNAs are emerging in cancer biology. This study explores the function of the CCAT1-70aa peptide in hepatocellular carcinoma (HCC) and its underlying mechanisms. Methods: Immunohistochemistry was used to detect CCAT1-70aa expression in HCC and adjacent tissues. An expression …

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RETRACTED: PAARH promotes M2 macrophage polarization and immune evasion of liver cancer cells through VEGF protein

Xianzhe Lu, Li Li, Jiajie Lin, Xianjian Wu et autres

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RETRACTED: LncRNA MEG3 suppresses hepatocellular carcinoma by stimulating macrophage M1 polarization and modulating immune system via inhibiting CSF-1 in vivo/vitro studies

Jiajie Lin, Junling Huang, Chuan Ping Tan, Siyang Wu et autres

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Acquired EGFR Resistance Mutation C797S in Pancreatic Adenocarcinoma Following Partial Response to Third-Generation EGFR Inhibitor Therapy

Brigitte Papa, Pranav Dorwal, Pamela Htain, Julie Robin et autres

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Migrated Laparoscopic Surgical Clips Causing Acute Cholangitis 32 Years After Laparoscopic Cholecystectomy

Yijie Yin, Su Kah Goh, Reizal Mohd Rosli, John‐Edwin Thomson et autres

Surgical clip migration post-laparoscopic cholecystectomy is a rare but important complication to consider in patients presenting with biliary obstruction. Titanium surgical clips are widely used in laparoscopic surgery to ligate vessels and ducts and are particularly important in laparoscopic cholecystectomy to ligate …

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N6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC

Chuan Ping Tan, Yanyan Huang, Zheng Huang, Yuanjia Ning et autres

Purpose: N 6 -methyladenosine (m 6 A) modification has shown critical roles in regulating mRNA fate. Non-coding RNAs also have important roles in various diseases, including hepatocellular carcinoma (HCC). However, the potential influences of m 6 A modification on non-coding RNAs are …

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Perforated duodenal diverticulum: protecting the ampulla through the imbrication technique of repair

Zachary Bunjo, Su Kah Goh, Hong Xiang Lee, Chuan Ping Tan

Duodenal diverticula are the most common type of small bowel diverticula. The pathogenesis remains unclear but it is hypothesised that raised intraluminal pressure, inflammation and/or intestinal dysmotility increases the risk of mucosa and submucosa herniation through the muscularis layer resulting in a …

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Combined chemotherapy and endoscopic ultrasound-guided intratumoral 32P implantation for locally advanced pancreatic adenocarcinoma: a pilot study

Jeevinesh Naidu, Dylan L. Bartholomeusz, Joshua Zobel, Romina Safaeian et autres

Abstract Background This study evaluated clinical outcomes of combined chemotherapy and endoscopic ultrasound (EUS)-guided intratumoral radioactive phosphorus-32 (32P) implantation in locally advanced pancreatic adenocarcinoma (LAPC). Methods Consecutive patients with newly diagnosed LAPC were recruited over 20 months. Baseline computed tomography and 18F-2-fluoro-2-deoxy-D-glucose …

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Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Stephan B. Dreyer, Rosanna Upstill‐Goddard, Viola Paulus-Hock, Clara Paris et autres

BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage …

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Long Noncoding RNA PART1 Promotes Hepatocellular Carcinoma Progression via Targeting miR-590-3p/HMGB2 Axis

Jian Xin Pu, Chuan Ping Tan, Zesheng Shao, Xianjian Wu et autres

Introduction: In East Asia, hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancer types. Long noncoding RNA (lncRNA) prostate androgen-regulated transcript 1 ( PART1 ) was reported to play crucial roles in regulating cancer progression. However, roles and mechanisms of …

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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Holly Brunton, Giuseppina Caligiuri, Richard N. Cunningham, Rosanna Upstill‐Goddard et autres

Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classical (pancreatic) and squamous. We find that these two subtypes are driven by distinct metabolic phenotypes. Loss of genes that drive endodermal lineage specification, HNF4A …

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