Joseph E. Mayer

The multicellular environment of the re‐entrant circuit in post‐myocardial infarction ventricular tachycardia: Beyond fibrosis

Mohammed N. Obeidat, Jaffar Al-Sheikhli, Andrew M. Blanks, Joseph E. Mayer et autres

Ventricular tachycardia (VT) in the post-myocardial-infarction heart is sustained by re-entry arising from slow and heterogeneous impulse propagation within the infarct border zone. Seminal histological and electrophysiological studies demonstrated that re-entry is enabled by conduction corridors of surviving myocardial bundles embedded within …

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Accuracy of non-invasive electrocardiographic imaging in scar-dependent ventricular tachycardia: relationship to arrhythmogenic substrate and imaging defined scar

Jaffar Al-Sheikhli, Xuezhe Wang, Joseph E. Mayer, Mohamed Anwar Mohamed et autres

AIMS: Accuracy data for non-invasive electrocardiographic imaging (ECGi) in defining the arrhythmogenic substrate for scar-dependent ventricular tachycardia (VT) is lacking. This study evaluated the accuracy of ECGi mapping to localize the arrhythmogenic substrate and assessed the relationship to myocardial scar, isthmus, exit, …

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Multiparametric Electrogram Feature Analysis for Ventricular Tachycardia Functional Extra-Stimulus Substrate Mapping

Joseph E. Mayer, Jaffar Al-Sheikhli, Xuezhe Wang, Rafaella Siang et autres

BACKGROUND: Functional extra-stimulus (ES) substrate mapping has been shown to reduce the recurrence of ventricular tachycardia (VT) compared with intrinsic rhythm mapping. However, there is no standardized approach to functional ES mapping. OBJECTIVES: This study investigated the accuracy of a range of …

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4-022 The influence of chronic amiodarone therapy on overall scar burden and myocardial voltages during ventricular tachycardia substrate mapping

Joseph E. Mayer, Jaffar Al-Sheikhli, Maria Niespialowska-Steuden, Ian Patchett et autres

Background/Introduction Amiodarone is a widely used class III anti-arrhythmic drug that is highly effective in the treatment and suppression of ventricular tachycardia (VT). Amiodarone non-competitively blocks both alpha- and beta-adrenergic receptors and increases action potential duration prolonging repolarisation and refractoriness. Amiodarone pre-VT …

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PO-04-172 REFINING VENTRICULAR TACHYCARDIA ABLATION TARGET AREAS: A COMPARATIVE STUDY OF LOW VOLTAGE ELECTROGRAM PEAK FREQUENCY DEFINED SUBSTRATE AND LATE POTENTIAL MAPPING

Joseph E. Mayer, Jaffar Al-Sheikhli, Maria Niespialowska-Steuden, James Winter et autres

PO-07-218 DIAGNOSTIC ACCURACY OF A NON-INVASIVE MAPPING SYSTEM FOR SCAR DEPENDENT VT EXIT SITE LOCALISATION: RELATIONSHIP TO MYOCARDIAL SCAR AND SUCCESSFUL ABLATION LESIONS

Jaffar Al-Sheikhli, Mohamed A. Mohamed, Rafaella Siang, Joseph E. Mayer et autres

1711: COST ANALYSIS OF UNIVERSAL BCVI SCREENING VERSUS EXTENDED DENVER CRITERIA AT A LEVEL 1 TRAUMA CENTER

Joseph E. Mayer, Charles Renner, Michael Sauder, Bader Kiwan et autres

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Functional Substrate Mapping: A New Frontier in the Treatment of Ventricular Tachycardia in Structural Heart Disease

Jaffar Al-Sheikhli, Patrick Dang Tran, Rafaella Siang, Maria Niespialowska-Steuden et autres

Functional substrate mapping has emerged as an essential tool for electrophysiologists, overcoming many limitations of conventional mapping techniques and demonstrating favourable long-term outcomes in clinical studies. However, a consensus on the definition of 'functional substrate' mapping remains elusive, hindering a structured approach …

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Novel real-time automation of combined frequency and low voltage substrate mapping to guide ablation for Brugada syndrome: a case report

Joseph E. Mayer, Jaffar Al-Sheikhli, Maria Niespialowska-Steuden, Elijah Raphael Behr et autres

Abstract Background Brugada syndrome (BrS) is an inherited cardiac condition that increases the risk of sudden cardiac death (SCD) due to ventricular arrhythmias. Catheter ablation has been shown to effectively reduce recurrent ventricular fibrillation (VF) episodes through targeting of abnormal electrograms predominantly …

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Detailed analysis of electrogram peak frequency to guide ventricular tachycardia substrate mapping

Joseph E. Mayer, Jaffar Al-Sheikhli, Maria Niespialowska-Steuden, Ian Patchett et autres

AIMS: Differentiating near-field (NF) and far-field (FF) electrograms (EGMs) is crucial in identifying critical arrhythmogenic substrate during ventricular tachycardia (VT) ablation. A novel algorithm annotates NF-fractionated signals enabling EGM peak frequency (PF) determination using wavelet transformation. This study evaluated the algorithms' effectiveness …

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PO-03-045 MAGNETIC RESONANCE IMAGING IN PATIENTS WITH MRI UNLABELLED CARDIAC IMPLANTABLE ELECTRONIC DEVICES. ASSOCIATED RISK, SAFETY AND LONG TERM CLINICAL OUTCOMES FROM A SINGLE U.K TERTIARY CENTRE

Joseph E. Mayer, Sarah Prescott, Vincent J. Walker, Aung Min Thant et autres

A Review of the Wide Range of Indications and Uses of Implantable Loop Recorders: A Review of the Literature

Chun Shing Kwok, Daniel N. Darlington, Joseph E. Mayer, Gaurav Panchal et autres

Implantable loop recorders (ILR) are devices that are implanted subcutaneously on the chest, which enables the continuous monitoring of arrhythmias for up to three years. These devices have an important role in helping to make a diagnosis and supporting decisions about the …

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