Dapeng Bi

Shape-independent fluidity in epithelial cell monolayers

Pradip Bera, Anh Q Nguyen, Molly McCord, Dapeng Bi et autres

Tissue fluidity regulates biological processes such as embryonic development, wound healing, and cancer metastasis. In confluent epithelia, where cell packing fraction is effectively fixed, the prevailing paradigm postulates that fluidity is governed by a geometric shape index determined by the balance of …

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Shape-Independent Fluidity in Epithelial Cell Monolayers

Pradip Bera, A. Nguyen, Molly McCord, Dapeng Bi et autres

Tissue fluidity regulates biological processes such as embryonic development, wound healing, and cancer metastasis. In confluent epithelia, where cell packing fraction is effectively fixed, the prevailing paradigm postulates that fluidity is governed by a geometric shape index determined by the balance of …

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Shape-Independent Fluidity in Epithelial Cell Monolayers

Pradip K. Bera, Anh Q Nguyen, Molly McCord, Dapeng Bi et autres

Tissue fluidity regulates biological processes such as embryonic development, wound healing, and cancer metastasis. In confluent epithelia, where cell packing fraction is effectively fixed, the prevailing paradigm postulates that fluidity is governed by a geometric shape index determined by the balance of …

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Cell-Cell Adhesion as a Double-Edged Sword in Tissue Fluidity.

Anh Q Nguyen, Pradip Bera, Jacob Notbohm, Dapeng Bi

Cell migration plays a fundamental role in numerous physiological processes, including embryonic development, wound healing, and cancer metastasis. While cell-cell adhesion is known to regulate motion by shaping cell morphology and intercellular force balance, its dynamic, rate-dependent contributions to tissue behavior remain …

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Cell-Cell Adhesion as a Double-Edged Sword in Tissue Fluidity

Anh Q Nguyen, Pradip Bera, Jacob Notbohm, Dapeng Bi

Cell migration plays a fundamental role in numerous physiological processes, including embryonic development, wound healing, and cancer metastasis. While cell-cell adhesion is known to regulate motion by shaping cell morphology and intercellular force balance, its dynamic, rate-dependent contributions to tissue behavior remain …

Cell-Cell Adhesion as a Double-Edged Sword in Tissue Fluidity

Anh Q Nguyen, Pradip Bera, Jacob Notbohm, Dapeng Bi

Cell migration plays a fundamental role in numerous physiological processes, including embryonic development, wound healing, and cancer metastasis. While cell-cell adhesion is known to regulate motion by shaping cell morphology and intercellular force balance, its dynamic, rate-dependent contributions to tissue behavior remain …

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Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis

Alexandra G. Bermudez, Zoe D. Latham, Johnny Diaz, Weihong Yan et autres

Epithelial tissues undergo dynamic transitions between fluid-like collective motion and mechanically jammed states during development, injury repair, and disease progression. However, the cellular programs that drive these transitions and regulate collective behavior remain unclear. Using a controlled crowding model integrated with live-cell …

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The Rheology of Living Tissues: From Cells to Organismal Mechanics

Sayantani Kayal, Anh Q Nguyen, Dapeng Bi

Biological tissue rheology investigates the mechanical behavior of tissues, emphasizing their viscoelastic and plastic properties that enable both solid-like elasticity and fluid-like viscosity under mechanical stress. These mechanical characteristics are pivotal in various physiological processes, such as embryonic development, tissue remodeling, wound …

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MultiCell: geometric learning in multicellular development

Haiqian Yang, Roy George, Anh Q Nguyen, Dapeng Bi et autres

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Nonmuscle myosin IIA (NMIIA) regulates anisotropic cell tension to maintain the hexagonal packing of mouse lens meridional row cells

Sadia T. Islam, Y. W. Tang, Heather Boliver, Dapeng Bi et autres

The mouse ocular lens is an excellent vertebrate model for epithelial cell hexagonal packing during tissue morphogenesis. As lens epithelial cells differentiate into fiber cells, the epithelial cells rearrange into hexagonally packed meridional row (MR) cells that further differentiate to form fiber …

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Origin of yield stress and mechanical plasticity in model biological tissues

Anh Q Nguyen, Junxiang Huang, Dapeng Bi

During development and under normal physiological conditions, biological tissues are continuously subjected to substantial mechanical stresses. In response to large deformations, cells in a tissue must undergo multicellular rearrangements to maintain integrity and robustness. However, how these events are connected in time …

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Epithelial Layer Fluidization by Curvature-Induced Unjamming

Margherita De Marzio, Amit Das, Jeffrey J. Fredberg, Dapeng Bi

The transition of an epithelial layer from a stationary, quiescent state to a highly migratory, dynamic state is required for wound healing, development, and regeneration. This transition, known as the unjamming transition (UJT), is responsible for epithelial fluidization and collective migration. Previous …

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