Rebekah G. Langston

Generation of Blood Vascular Endothelial-Neural 3D Organoids by Serial Induction of Differentiation on Human iPSC-Derived Embryoid Bodies

Tongguang Wang, Anna M. Bagnell, V L McDonald, Benjamin D. Gastfriend et autres

The 3D brain organoids have been widely used as a tool to study human brain development and disorders. Although angiogenesis and blood vascular endothelial cells play important roles in brain development and pathogenesis in neurological disorders, most 3D brain organoids lack inherent …

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Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level

Monica E. Mesecar, Megan F. Duffy, Dominic J. Acri, Jinhui Ding et autres

As age is a significant risk factor for multiple neurodegenerative diseases, investigating normal brain aging may help identify molecular events contributing to increased disease risk over time. Single-nucleus RNA sequencing (snRNA-seq) enables analysis of gene expression changes within specific cell-types, offering insights …

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Single cell RNA sequencing reveals limited effects of Lrrk2 genotype in a mouse model of acute CNS inflammation

Alice Kaganovich, Liam Horan-Portelance, Natalie Landeck, Dominic J. Acri et autres

Abstract BACKGROUND Previous data implicates neuroinflammation in the pathogenesis of Parkinson’s disease (PD). Of the genes associated with PD, Leucine rich repeat kinase 2 (LRRK2) has previously been proposed to play a role in neuroinflammation. However, the extent to which LRRK2 is …

3D organoids containing endothelial and neural cells generation by serial inductions of differentiation on human iPSC-derived embryoid bodies

Tongguang Wang, Anna M. Bagnell, Valerie McDonald, Benjamin D. Gastfriend et autres

3D brain organoids have been widely used as a tool to study human brain development and disorders. Although endothelial cells play important roles in the brain development and pathogenesis in neurological disorders, most 3D brain organoids lack inherent endothelial cells and need …

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Intracranial hematolymphoid malignancies: A case series with molecular characterization

Rebekah G. Langston, Heather Pinckard-Dover, Grace Guzman, Christopher P. Wardell et autres

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Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell Level

Megan F. Duffy, Jinhui Ding, Rebekah G. Langston, Syed Islamuddin Shah et autres

Given that age is a significant risk factor for multiple neurodegenerative diseases, investigating normal brain aging may help identify molecular events that may contribute to increased disease risk over time. Single-nucleus RNA sequencing (snRNA-seq) enables analysis of gene expression changes within specific …

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Divergent effects of aging across human brain regions at single cell resolution

Megan F. Duffy, Jinhui Ding, Rebekah G. Langston, D. Thad Whitaker et autres

Single nuclear RNA-sequencing was performed on human post-mortem brain tissue from four distinct nuclei that have implications for neurodegenerative diseases, including Alzheimer's and Parkinson’s diseases. Younger, aged 20s to 30s, and middle-aged and older, aged 60s to 80s, adults were used to …

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Divergent effects of aging across human brain regions at single cell resolution

Megan F. Duffy, Jinhui Ding, Rebekah G. Langston, D. Thad Whitaker et autres

Single nuclear RNA-sequencing was performed on human post-mortem brain tissue from four distinct nuclei that have implications for neurodegenerative diseases, including Alzheimer's and Parkinson’s diseases. Younger, aged 20s to 30s, and middle-aged and older, aged 60s to 80s, adults were used to …

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Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell Level

Megan F. Duffy, Jinhui Ding, Rebekah G. Langston, D. Thad Whitaker et autres

Single nuclear RNA-sequencing was performed on human post-mortem brain tissue from four distinct regions that have implications for neurodegenerative diseases, including Alzheimer's and Parkinson’s diseases. Younger, aged 20s to 30s, and middle-aged and older, aged 60s to 80s, adults were used to …

us (code pays fourni par la source)

Divergent effects of aging across human brain regions at single cell resolution

Megan F. Duffy, Jinhui Ding, Rebekah G. Langston, D. Thad Whitaker et autres

Single nuclear RNA-sequencing was performed on human post-mortem brain tissue from four distinct nuclei that have implications for neurodegenerative diseases, including Alzheimer's and Parkinson’s diseases. Younger, aged 20s to 30s, and middle-aged and older, aged 60s to 80s, adults were used to …

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Reconstruction of Anterior Skull Base Defects with Radial Forearm-Free Flaps

Rebekah G. Langston, Mauricio Alejandro Moreno

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Association of a common genetic variant with Parkinson’s disease is mediated by microglia

Rebekah G. Langston, Alexandra G. Beilina, Xylena Reed, Alice Kaganovich et autres

Studies of multiple neurodegenerative disorders have identified many genetic variants that are associated with risk of disease throughout a lifetime. For example, Parkinson’s disease (PD) risk is attributed in part to both coding mutations in the leucine-rich repeat kinase 2 ( LRRK2 …

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