Elissaveta P. Petrova

Quantum-Chemical Calculation of Electron Density Distributions and Structures of Cellulose, Chitin, and Chitosan Tetramers

E. S. Abramova, Anton A. Murav’ev, Nikolai P. Novoselov, Elissaveta P. Petrova et autres

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Supp. Fig. 2 from Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

Kai Schiemann, Natalya Belousova, Armine Matevossian, Kalyan C. Nallaparaju et autres

Supplementary Figure 2

Supp. Fig. 1 from Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

Kai Schiemann, Natalya Belousova, Armine Matevossian, Kalyan C. Nallaparaju et autres

Supplementary Figure 1

Data from Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

Kai Schiemann, Natalya Belousova, Armine Matevossian, Kalyan C. Nallaparaju et autres

Abstract While A2A adenosine receptor (AR) was considered as a major contributor to adenosine-mediated immunosuppression, A2B, having the lowest affinity to adenosine, has also emerged as a potential contributor to tumor promotion. Therefore, in adenosine-rich tumor microenvironment (TME), where A2B could be …

Supp. Fig. 2 from Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

Kai Schiemann, Natalya Belousova, Armine Matevossian, Kalyan C. Nallaparaju et autres

Supplementary Figure 2

Supplementary Methods from Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

Kai Schiemann, Natalya Belousova, Armine Matevossian, Kalyan C. Nallaparaju et autres

Supplementary Materials and Methods

Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

Kai Schiemann, Natalya Belousova, Armine Matevossian, Kalyan C. Nallaparaju et autres

While A2A adenosine receptor (AR) was considered as a major contributor to adenosine-mediated immunosuppression, A2B, having the lowest affinity to adenosine, has also emerged as a potential contributor to tumor promotion. Therefore, in adenosine-rich tumor microenvironment (TME), where A2B could be complementary …

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High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells

Johannes Krumm, Elissaveta P. Petrova, Severin Lechner, Julia Mergner et autres

Myeloid-derived suppressor cells (MDSC) are a heterogeneous cell population of incompletely differentiated immune cells. They are known to suppress T cell activity and are implicated in multiple chronic diseases, which make them an attractive cell population for drug discovery. Here, we characterized …

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Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo

Rinat Zaynagetdinov, Kai Schiemann, Kalyan C. Nallaparaju, Natalya V. Belousova et autres

Abstract Under physiological conditions, the extracellular concentrations of adenosine are low, however, levels dramatically increase under metabolically stressful conditions, including inflammation and cancer. The regulatory functions of adenosine are mediated through four members of the adenosine receptor family: A1, A2A, A2B, and …

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A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease

Luuk de Haan, Johnny Suijker, Ruthger van Roey, Nina Berges et autres

The recruitment of T cells is a crucial component in the inflammatory cascade of the body. The process involves the transport of T cells through the vascular system and their stable arrest to vessel walls at the site of inflammation, followed by …

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Abstract A099: Using high-throughput phenotypic screening to identify therapeutic targets for the inhibition of myeloid-derived suppressor cells

Elissaveta P. Petrova, Sandra Schäffner, Jan-Carsten Pieck, Christian Herhaus et autres

Abstract Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive function, which inhibit the antitumor activity of T-cells and natural killer (NK) cells. MDSC number is greatly increased in tumor-bearing mice and in cancer patients, and in …

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Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth

Elissaveta P. Petrova, Arne Scholz, Juliane Paul, Andrea Sturz et autres

// Elissaveta Petrova 1,2 , Arne Scholz 1 , Juliane Paul 1 , Andrea Sturz 1 , Katja Haike 1 , Franziska Siegel 1 , Dominik Mumberg 1 and Ningshu Liu 1 1 Bayer AG, Drug Discovery, Berlin, Germany 2 Current address: …

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