Yuanzhong Yang

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Fan Luo, Jiaxin Cao, Qun Chen, Zhenhai Lu et autres

The ubiquitin-editing enzyme A20 is essential for maintaining inflammatory homeostasis, yet its role in chemoresistance remains unclear. To investigate how A20 regulates oxaliplatin resistance in colorectal cancer (CRC), with a focus on A20-mediated IKK-β monoubiquitylation at K163. A prospective, randomized Phase III …

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BMI ‐dependent prognostic role of EEF1G in breast cancer: A 15‐year follow‐up of the Guangzhou Breast Cancer Cohort Study

Na Li, Chengkun Xiao, Shushu Han, Minjie Lu et autres

Abstract Objective Eukaryotic elongation factor 1 gamma (EEF1G) has emerged as a potential prognostic marker in various malignancies. Yet, its association with breast cancer (BC) prognosis, particularly in the context of body mass index (BMI) status, remains unexplored. Therefore, we investigated the …

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DTX3 suppresses bladder cancer cell invasion and metastasis by inhibiting the Notch signaling pathway

Yu Cheng, Qi Sun, Ya Chen, Jiayu Wang et autres

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Systematic Analysis of Factors Affecting Human Epidermal Growth Factor Receptor 2 Interpretation Consistency: Staining Protocols, Artificial Intelligence–Based Image Standardization, and Classification Criteria

Chen Jiang, Mei Li, Chengyou Zheng, Shumei Yan et autres

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Adenocarcinoma of the rete testis: clinicopathological study of 18 cases with emphasis on MET amplification and a review of the literature

Ya Chen, Qi Sun, Xinghua Hou, Sha Fu et autres

BACKGROUND: Knowledge regarding adenocarcinoma of the rete testis (ACRT) is extremely limited due to its scarcity. METHODS AND RESULTS: This study enrolled 18 patients with ACRT from multiple institutions. Clinicopathological and immunohistochemical features were investigated, together with a comprehensive review of 95 …

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Primary adenocarcinoma of the spermatic cord: a case report and review of the literature

Qi Sun, Yuanzhong Yang, Chen Ya, Xin An et autres

BACKGROUND: Primary malignant neoplasms of the spermatic cord are extremely rare, with most reported cases being sarcomas or metastatic carcinomas. However, primary adenocarcinoma of the spermatic cord has not been previously reported. CASE PRESENTATION: A 34-year-old male with a solid mass in …

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Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma

Hao Duan, Yuan Xie, Suwen Wu, Guangyin Zhao et autres

BACKGROUND: Patients with glioblastoma (GBM) have a poor prognosis and limited treatment options. The mRNA decapping enzyme scavenger (DCPS) is a cap-hydrolyzing enzyme. The DCPS inhibitor RG3039 exhibited excellent central nervous system bioavailability in vivo and was safe and well tolerated in …

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FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Yunzhi Zou, Xiaoqiong Bao, Depei Li, Zhen Ye et autres

Growth hormone-secreting pituitary neuroendocrine tumors can be pathologically classified into densely granulated (DGGH) and sparsely granulated types (SGGH). SGGH is more aggressive and associated with a poorer prognosis. While epigenetic regulation is vital in tumorigenesis and progression, the role of N 6 …

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Single-cell atlas profiling revealed cellular characteristics and dynamic changes after PD-1 blockade therapy of brain metastases from laryngeal squamous cell carcinoma

Yunzhi Zou, Hao Bo Duan, Zekun Deng, Rong Xiang et autres

Brain metastasis (BM) in laryngeal squamous cell carcinoma (LSCC) is uncommon but prognosis is poor. Anti-PD-1 immunotherapy benefits some advanced LSCC cases, yet its efficiency is limited by tumor complexity. We analyzed paired metastatic tumor samples from before and after immunotherapy using …

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TIM-3/CD68 double-high expression in Glioma: Prognostic characteristics and potential therapeutic approaches

Wanming Hu, De‐Pei Li, Yuanzhong Yang, Yongqiang Zheng et autres

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Primary Adenocarcinoma of the Spermatic Cord: A Case Report and Review of the Literature

Qi Sun, Yuanzhong Yang, Chen Ya, Xin An et autres

Abstract Background Primary malignant neoplasms of the spermatic cord are extremely rare, with most reported cases being sarcomas or metastatic carcinomas. However, primary adenocarcinoma of the spermatic cord has not been previously reported. Case presentation: A 34-year-old male with a solid mass …

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Primary Adenocarcinoma of the Spermatic Cord: A Case Report with Review of the Literature

Qi Sun, Yuanzhong Yang, Chen Ya, Xin An et autres

Abstract Background Primary malignant neoplasms of the spermatic cord are extremely rare, with most reported cases being sarcomas or metastatic carcinomas. However, primary adenocarcinoma of the spermatic cord has not been previously reported. Case presentation: A 34-year-old male with a solid mass …

cn (code pays fourni par la source)