Prateek Mahalwar

The role of xanthophores in the stripe pattern formation of Zebrafish, Danio rerio

Prateek Mahalwar

Animals have evolved a fascinating diversity in their color patterns, which serves as an essential component of their survival strategies. Color pattern formation in zebrafish (Danio rerio) is a great model system to study general pattern formation involving different cell types. The …

Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish

Prateek Mahalwar, Ajeet Pratap Singh, Andrey Fadeev, Christiane Nüsslein‐Volhard et autres

The conspicuous striped coloration of zebrafish is produced by cell-cell interactions among three different types of chromatophores: black melanophores, orange/yellow xanthophores and silvery/blue iridophores. During color pattern formation xanthophores undergo dramatic cell shape transitions and acquire different densities, leading to compact and …

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Pigment Cell Progenitors in Zebrafish Remain Multipotent through Metamorphosis

Ajeet Pratap Singh, April Dinwiddie, Prateek Mahalwar, Ursula Schach et autres

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Homotypic cell competition regulates proliferation and tiling of zebrafish pigment cells during colour pattern formation

Brigitte Walderich, Ajeet Pratap Singh, Prateek Mahalwar, Christiane Nüsslein‐Volhard

The adult striped pattern of zebrafish is composed of melanophores, iridophores and xanthophores arranged in superimposed layers in the skin. Previous studies have revealed that the assembly of pigment cells into stripes involves heterotypic interactions between all three chromatophore types. Here we …

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A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist

Xuefan Gao, Ute Metzger, Paolo Panza, Prateek Mahalwar et autres

Floor-plate-derived extracellular signaling molecules, including canonical axon guidance cues of the Netrin family, control neuronal circuit organization. Despite the importance of the floor plate as an essential signaling center in the developing vertebrate central nervous system, no systematic approach to identify binding …

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Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish

Prateek Mahalwar, Brigitte Walderich, Ajeet Pratap Singh, Christiane Nüsslein‐Volhard

Origin of fish pigment cell for pattern Zebrafish stripes arise from the interactions of pigment cells: black melanophores, iridescent iridophores, and yellow-orange xanthophores. Melanophores and iridophores develop from nerve-associated stem cells, but the origin of xanthophores is unclear. Two studies now reveal …

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Utility of saliva and hair follicles in donor selection for hematopoietic stem cell transplantation and chimerism monitoring

Gurvinder Kaur, Neeraj Kumar, Ramya Nandakumar, C. C. Rapthap et autres

Selection of an HLA identical donor is a critical pre-requisite for successful hematopoietic stem cell transplantation (HSCT). Most transplant centers utilize blood as the most common source of DNA for HLA testing. However, obtaining blood through phlebotomy is often challenging in patients …

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