Jerónimo Blanco

Genetic characterization of drug-induced long QT syndrome in a large prospective cohort

Bieito Campos, B Rodriguez Santiago, Jerónimo Blanco, Héctor Hernández Ontiveros et autres

Abstract Introduction Drug-induced long QT syndrome (DI-LQTS) is a clinical entity with a poorly defined etiopathogenesis. Purpose The objective of the study was to determine the genetic basis of a prospective cohort of patients with DI-LQTS in the setting of a tertiary …

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Suicide gene therapy by canine mesenchymal stem cell transduced with thymidine kinase in a u-87 glioblastoma murine model: Secretory profile and antitumor activity

Antonio J. Villatoro, Cristina Alcoholado, María del Carmen Martín‐Astorga, Núria Rubio et autres

The role played by certain domestic species such as dogs as a translational model in comparative oncology shows great interest to develop new therapeutic strategies in brain tumors. Gliomas are a therapeutic challenge that represents the most common form of malignant primary …

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Engineered microtissues for the bystander therapy against cancer

Bárbara Blanco‐Fernandez, Irene Cano-Torres, Cristina Garrido, Gerard Rubí-Sans et autres

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Fast-Proliferating Adipose Tissue Mesenchymal-Stromal-Like Cells for Therapy

Núria Rubio, Julio Rodriguez Bagó, Elisabet Aguilar, Jerónimo Blanco et autres

Human mesenchymal stromal cells, whether from the bone marrow or adipose tissue (hASCs), are promising cell therapy agents. However, generation of abundant cells for therapy remains to be a challenge, due to the need of lengthy expansion and the risk of accumulating …

Polymeric Composite Dressings Containing Calcium-Releasing Nanoparticles Accelerate Wound Healing in Diabetic Mice

Soledad Pérez‐Amodio, Núria Rubio, Olaia F. Vila, Claudia Navarro‐Requena et autres

Objective: Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, resulting in nonhealing chronic wounds. Chronic wounds are a socioeconomic burden, …

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Nanopartículas multicomponente y uso de las mismas

Óscar Meca‐Cortés, Gema Martínez Martínez, Anna Cascante, Jerónimo Blanco et autres

La invención se refiere a nanopartículas multicomponente para la transfección y selección de células . Las nanopartículas comprenden (a) nanopartículas de óxido de hierro superparamagnético (SPION), (b) un polímero que es un poli (beta-amino éster) (pBAE) modificado en los extremos con al …

In Vivo Retargeting of Poly(beta aminoester) (OM‐PBAE) Nanoparticles is Influenced by Protein Corona

Cristina Fornaguera, Marta Guerra‐Rebollo, Miguel Ángel Lázaro, Anna Cascante et autres

One of the main bottlenecks in the translation of nanomedicines from research to clinics is the difficulty in designing nanoparticles actively vectorized to the target tissue, a key parameter to ensure efficacy and safety. In this group, a library of poly(beta aminoester) …

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Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure

Marta Guerra‐Rebollo, Cristina Garrido, Lourdes Sánchez‐Cid, Carolina Soler‐Botija et autres

The existence of radio- and chemotherapy-surviving cancer stem cells is currently believed to explain the inefficacy of anti-glioblastoma (GBM) therapies. The aim of this study was to determine if a therapeutic strategy specifically targeting GBM stem cells (GSC) would completely eradicate a …

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SPIONs’ Enhancer Effect on Cell Transfection: An Unexpected Advantage for an Improved Gene Delivery System

Laura Balcells, Cristina Fornaguera, Pau Brugada-Vilà, Marta Guerra‐Rebollo et autres

Abstract The clinical implantation of gene therapy is hindered by the limitations of current gene delivery vectors, namely, safety issues regarding viral vectors and low transfection efficacy regarding nonviral vectors. Thus, the design of safe and efficient gene carriers is a key …

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Glioblastoma Bystander Cell Therapy: Improvements in Treatment and Insights into the Therapy Mechanisms

Marta Guerra‐Rebollo, Carolina Nogueira de Moraes, Cristina Alcoholado, Carolina Soler‐Botija et autres

A preclinical model of glioblastoma (GB) bystander cell therapy using human adipose mesenchymal stromal cells (hAMSCs) is used to address the issues of cell availability, quality, and feasibility of tumor cure. We show that a fast proliferating variety of hAMSCs expressing thymidine …

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APC Targeting: mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo (Adv. Healthcare Mater. 17/2018)

Cristina Fornaguera, Marta Guerra‐Rebollo, Miguel Ángel Lázaro, Cristina Castells‐Sala et autres

The study in article 1800335 by Salvador Borrós and co-workers, takes advantage of the known versatile properties of the oligopeptide end-modified poly (β-amino esters) (OM-PBAEs) to complex mRNA and form nanoparticles. It is demonstrated that the selection of the appropriate end-oligopeptide modifications …

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mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo

Cristina Fornaguera, Marta Guerra‐Rebollo, Miguel Ángel Lázaro, Cristina Castells‐Sala et autres

The encapsulation of mRNA in nanosystems as gene vaccines for immunotherapy purposes has experienced an exponential increase in recent years. Despite the many advantages envisaged within these approaches, their application in clinical treatments is still limited due to safety issues. These issues …

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