Bregje Mol

The longstanding issue of the benefit of ursodeoxycholic acid in primary sclerosing cholangitis: a long-term population-based study

Bregje Mol, Kim van Munster, R Weersma, Akin Inderson et autres

BACKGROUND: Although ursodeoxycholic acid (UDCA) is commonly prescribed for primary sclerosing cholangitis (PSC), a beneficial long-term effect on solid clinical endpoints has not yet been established. This study evaluated the efficacy of UDCA on long-term transplant-free survival in a longitudinal population-based cohort. …

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SAT-418-YI Enhanced liver fibrosis test significantly improves the predictive value of the Amsterdam-Oxford model in primary sclerosing cholangitis

Jutta van Crevel, Tim Middelburg, Bregje Mol, Johannes Bogaards et autres

OS-087-YI Enhanced liver fibrosis test and vibration controlled transient elastography as surrogate endpoints in primary sclerosing cholangitis

Tim Middelburg, Jutta van Crevel, Bregje Mol, Liesbeth de Vries et autres

Interpreting surgical associations in primary sclerosing cholangitis: Caution in clinical messaging

Bregje Mol, Palak J Trivedi

Primary sclerosing cholangitis (PSC) remains one of the greatest unmet needs in modern hepatology, given its ill-defined etiology, critical absence of medical therapy, and the fact that transplantation is still the only life-extending intervention for patients. Moreover, clinical trials in PSC continue …

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Reply to: “Unaddressed concerns of potential follow-up bias in the International PSC Registry”

Bregje Mol, Johannes A. Bogaards, Cyriel Y. Ponsioen

We have read with interest the letter from colleagues Shanahan and Slattery, in which they praise our efforts to analyse IPSCR data, but also express their concern about potentials for bias in our analysis.1 We welcome the concerns as it provides an …

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Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC

Bregje Mol, Moyrha van Nieuwamerongen, Kim N. van Munster, Martti Färkkilä et autres

Background & Aims: The gut-liver axis is believed to be crucial in the pathogenesis of primary sclerosing cholangitis (PSC). However, the impact of colectomy on liver disease progression is unclear. Our study estimated the effect of colectomy on PSC progression with correction …

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Reply: Competing risk and surveillance thresholds for HCC in patients with PSC

Magnus Holmer, Michael Ingre, Martti A. Färkkilä, Cyriel I. J. Ponsioen et autres

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Validation of Quantitative Magnetic Resonance Cholangiopancreatography Metrics in Prediction of Transplant-free Survival in Primary Sclerosing Cholangitis

Tim E. Middelburg, Bregje Mol, Carlos Ferreira, Tom R. Davis et autres

Background and aims Qualitative magnetic resonance cholangiopancreatography (MRCP) scoring models in primary sclerosing cholangitis (PSC) are hampered by interobserver variability and evidence for quantitative MRCP has so far been limited by cohort sizes, follow-up time and lack of validation. This study aimed …

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Spatial transcriptomics and immunophenotyping uncover chronic inflammation-induced immune adaptations favoring dysplasia development in patients at risk of colitis-associated cancer

Sofía Frigerio, Hina Naz Khan, Bregje Mol, Andra Neefjes‐Borst et autres

BACKGROUND AND AIMS: Colitis-associated cancer (CAC) is the most severe complication of inflammatory bowel disease (IBD). We hypothesized that chronic inflammation activates endogenous anti-inflammatory mechanisms that promote dysplasia by undermining immunosurveillance. Our aim was to determine chronic inflammation-induced immune cell reprogramming in …

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Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study

Magnus Holmer, Michael Ingre, Martti A. Färkkilä, Cyriel I. J. Ponsioen et autres

BACKGROUND AND AIMS: The risk of HCC in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC, questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longitudinal multicenter cohort with …

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Epidemiological and economical burden of cholestatic liver disease

Bregje Mol, Ellen Werner, Emma Louise Culver, Adriaan J. van der Meer et autres

The main cholestatic liver diseases comprise primary sclerosing cholangitis, primary biliary cholangitis, and IgG4-related cholangitis. Despite being classified as rare diseases, these are becoming gradually more important in the field of hepatology since their incidence is slowly rising while the viral hepatitis …

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Surveillance of primary sclerosing cholangitis – a comparison of scheduled or on-demand ERCP with annual MRI surveillance: a multicenter study

Nina Barner‐Rasmussen, Antonio Molinaro, Bregje Mol, Cyriel I. J. Ponsioen et autres

Background: Primary sclerosing cholangitis (PSC) is associated with a high risk of hepatobiliary malignancy, especially cholangiocarcinoma (CCA). There are no good tumor markers to screen for CCA, and current recommendations for PSC monitoring are mainly based on expert opinions. The optimal strategy …

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