Hiroki Kurihara

Hox/Meis-dependent gene-regulatory transition underlies cardiopharyngeal neural crest diversification

Akiyasu Iwase, Yasunobu Uchijima, Daiki Seya, Mayuko Kida et autres

Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks underlying their differentiation in the cardiopharyngeal region remain unclear. Here, we integrate single-cell RNA-seq, spatial transcriptomics, and multiomic analyses to construct a …

jp (code pays fourni par la source)

Suppressing glutamate dehydrogenase guides hematopoietic stem cell divisions into self-renewal

Michihiro Hashimoto, Michie Uchikawa, Yuichiro Arima, Akiyasu Iwase et autres

Abstract Hematopoietic stem cells (HSCs) self-renew to expand their pool but often differentiate upon division. Thus, it remains unclear how HSCs maintain their stemness during or after division. Here, we show that the suppression of glutamate dehydrogenase (Glud1), a key enzyme responsible …

jp, cn (code pays fourni par la source)

G Protein-Mediated Allosteric Modulation of Ligand Binding in Class A GPCRs: Receptor–Ligand–Transducer Ensembles in Disease and Drug Discovery

Yukiko Kurihara, Hiroki Kurihara

G protein-coupled receptors (GPCRs) are dynamic allosteric proteins whose signaling properties are governed by reciprocal communication between extracellular ligand-binding sites and intracellular transducer interfaces. Although classical pharmacological models established the concept that ligand binding and G protein coupling are thermodynamically linked, recent …

jp (code pays fourni par la source)

Author Reply to Peer Reviews of Hox-Meis-relayed spatial gene regulatory transition underlies cardiopharyngeal neural crest diversification revealed by multimodal analysis

Akiyasu Iwase, Yasunobu Uchijima, Daiki Seya, Mayuko Kida et autres

jp (code pays fourni par la source)

Hox – Meis -relayed gene regulatory transition underlies cardiopharyngeal neural crest diversification

Akiyasu Iwase, Yasunobu Uchijima, Daiki Seya, Mayuko Kida et autres

Abstract Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks (GRNs) underlying their differentiation in the cardiopharyngeal region remain unclear. Here, we integrate single-cell RNA-seq, spatial transcriptomics, and multiomic analyses to …

jp, us (code pays fourni par la source)

酸化還元活性なフェニレンジアミド配位子をもつチタン(IV)錯体の合成

Ryoya Yajima, 大樹 栗原, Hiroki Kurihara, Yutaka Ishida et autres

On the Maxillofacial Development of Mice, Mus musculus

Hiroki Higashiyama, Shunya Kuroda, Akiyasu Iwase, Naoki Irie et autres

The maxillofacial region is one of the most complex areas in the vertebrate body plan. The homology of the upper jaw bones remain controversial, both between mammals and nonmammalian amniotes and among humans and other mammals, leading to various hypotheses on how …

jp (code pays fourni par la source)

Author response for "On the Maxillofacial Development of Mice, Mus musculus"

Hiroki Higashiyama, Shunya Kuroda, Akiyasu Iwase, Naoki Irie et autres

Sex differences in the functional morphology of coronary arteries in embryonic mice

Shion Nagasawa, Masami Kodama, K. Sakamoto, Koichi Nishiyama et autres

This study introduces a novel coronary angiography method for analyzing murine embryonic hearts, revealing sex differences in coronary artery morphology and contractile function in the late stage of the fetal period. By categorizing heart components based on size, we unveil nuanced insights …

jp (code pays fourni par la source)

Sirt3 Regulates Proliferation and Progesterone Production in Leydig Cells via Suppression of Reactive Oxygen Species

Hisanori Matoba, Chifumi Fujii, Kazuaki Maruyama, Masatomo Kawakubo et autres

Sirt3 is a mitochondrial protein deacetylase functioning in energy metabolism, regulation of intracellular reactive oxygen species (ROS) levels, and aging. Although Sirt3 loss has negative effects on fertility of oocytes during in vitro fertilization and on progesterone production in granulosa cells, Sirt3's …

jp (code pays fourni par la source)

Novel definition and quantitative analysis of branch structure with topological data analysis

Haruhisa Oda, Mayuko Kida, Yoichi Nakata, Hiroki Kurihara

While branching network structures abound in nature, their objective analysis is more difficult than expected because existing quantitative methods often rely on the subjective judgment of branch structures. This problem is particularly pronounced when dealing with images comprising discrete particles. Here we …

A three-dimensional model with two-body interactions for endothelial cells in angiogenesis

Kazuma Sakai, Tatsuya Hayashi, Yusuke Sakai, Jun Mada et autres

We introduce a three-dimensional mathematical model for the dynamics of vascular endothelial cells during sprouting angiogenesis. Angiogenesis is the biological process by which new blood vessels form from existing ones. It has been the subject of numerous theoretical models. These models have …

jp (code pays fourni par la source)