Koichi Nishiyama

Changes in diplopia after teprotumumab therapy in patients with active thyroid eye disease

Ai Kozaki, Nobuyuki Sato, Shunsuke Kawaguchi, Rishu Inoue et autres

Association of smoking with thyroid eye disease and related diplopia in a Japanese population: a retrospective study

Ai Kozaki, Rishu Inoue, Natsuko Watanabe, Nobuyuki Sato et autres

jp (code pays fourni par la source)

Teprotumumab for dysthyroid optic neuropathy: early functional and structural improvement in a retrospective case series

Ai Kozaki, Rishu Inoue, Natsuko Watanabe, Nobuyuki Sato et autres

Dysthyroid optic neuropathy (DON) is a severe, vision-threatening manifestation of thyroid eye disease. We conducted a retrospective descriptive case series of consecutive patients with DON treated with teprotumumab at a single center to evaluate functional, structural, magnetic resonance imaging (MRI)-based inflammatory, and …

jp (code pays fourni par la source)

Biomechanical control of vascular morphogenesis by the surrounding stiffness

Yasuyuki Hanada, Semanti Halder, Yuichiro Arima, Misato Haruta et autres

Sprouting angiogenesis is a form of morphogenesis which expands vascular networks from preexisting networks. However, the precise mechanism governing efficient branch elongation driven by directional movement of endothelial cells (ECs), while the lumen develops under the influence of blood inflow, remains unknown. …

jp (code pays fourni par la source)

Background and ophthalmic features of patients with thyroid eye disease with dysthyroid optic neuropathy in Japan

Ai Kozaki, Rishu Inoue, Koichi Nishiyama, Toshu Inoue

To evaluate the background and ophthalmic features of patients with dysthyroid optic neuropathy (DON) requiring prompt diagnosis and treatment. This study included 72 eyes of 42 patients with DON (males, 17; females, 25; age, 58 ± 12 years). Patients underwent smoking history …

Sex differences in the functional morphology of coronary arteries in embryonic mice

Shion Nagasawa, Masami Kodama, K. Sakamoto, Koichi Nishiyama et autres

This study introduces a novel coronary angiography method for analyzing murine embryonic hearts, revealing sex differences in coronary artery morphology and contractile function in the late stage of the fetal period. By categorizing heart components based on size, we unveil nuanced insights …

jp (code pays fourni par la source)

Duration of treatment for thyroid eye disease

Ai Kozaki, Rishu Inoue, Yaji Naoko, Ai Hagimoto et autres

Subcutaneous Injections of Triamcinolone Acetonide for Upper Eyelid Retraction and Swelling Associated with Thyroid Eye Disease: A Retrospective Case Series Study

Ai Kozaki, Rishu Inoue, Naoko Yaji, Koichi Nishiyama et autres

Purpose: To evaluate the efficacy of subcutaneous injection of triamcinolone acetonide (SCTA) in treating upper eyelid retraction and swelling in patients with thyroid eye disease (TED). Patients and Methods: This case series included consecutive patients (aged 16-69 years, monitored from June 2012 …

Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts

Haruko Watanabe‐Takano, Katsuhiro Kato, Eri Oguri‐Nakamura, Tomohiro Ishii et autres

Abstract Alveologenesis is a spatially coordinated morphogenetic event, during which alveolar myofibroblasts surround the terminal sacs constructed by epithelial cells and endothelial cells (ECs), then contract to form secondary septa to generate alveoli in the lungs. Recent studies have demonstrated the important …

jp, de (code pays fourni par la source)

Biomechanical control of vascular morphogenesis by the surrounding stiffness

Koichi Nishiyama, Yasuyuki Hanada, Semanti Halder, Misato Haruta et autres

Abstract Sprouting angiogenesis is a form of morphogenesis which expands vascular networks from the preexisting ones in both developmental and postnatal settings. During this process, endothelial cells (ECs) collectively elongate new branches via their directional movement. Almost simultaneously, the vessel lumen develops …

jp (code pays fourni par la source)

Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice

K. Yamamoto, Haruko Watanabe‐Takano, Eri Oguri‐Nakamura, Hitomi Matsuno et autres

Vascular permeability is dynamically but tightly controlled by vascular endothelial (VE)-cadherin-mediated endothelial cell-cell junctions to maintain homeostasis. Thus, impairments of VE-cadherin-mediated cell adhesions lead to hyperpermeability, promoting the development and progression of various disease processes. Notably, the lungs are a highly vulnerable …

jp (code pays fourni par la source)

Cerebral infarction after anaphylactic shock due to cold-induced urticaria

Shinya Takeuchi, Mutsumi Miyauchi, Tomohito Kadota, Mitsunori Fukuda et autres

Cold-induced urticaria can lead to anaphylaxis, biphasic reactions and stroke. Prompt diagnosis is necessary because thrombolytic therapy may help resolve the condition. Cold-induced urticaria is characterized by pruritic wheals and/or angioedema due to the release of mast cell degranulation and inflammatory mediators. …

jp (code pays fourni par la source)