Accès ouvert
2026
article
OpenAlex
Abdulrahman AlSweed, Madain S. Alsanea, Fatimah S. Alhamlan, A. Alqahtani et autres
Abstract Background Cytomegalovirus (CMV) is a substantial cause of morbidity in immunocompromised populations, particularly among solid organ and bone marrow transplant recipients. The emergence of novel mutations, particularly within conserved genomic regions, presents challenges for interpreting genotypic resistance and guiding therapy. The …
sa
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Accès ouvert
2026
article
OpenAlex
Madain S. Alsanea, Abdulrahman AlSweed, Fatimah S. Alhamlan, A. Alqahtani et autres
Abstract Background Candida glabrata is an opportunistic pathogen that has emerged as a major cause of invasive candidiasis, particularly among immunocompromised patients. The high mortality rates associated with C. glabrata infections, ranging from 40% to 60%, highlight the urgent need for rapid …
sa
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Accès ouvert
2025
article
OpenAlex
Abdulrahman AlSweed, Madain S. Alsanea, Reem S. Almaghrabi, Ahmed A. Al‐Qahtani et autres
Background Human cytomegalovirus (HCMV) is a significant opportunistic pathogen affecting immunocompromised individuals, particularly solid organ and hematopoietic stem cell transplant recipients. The emergence of mutations within conserved genomic regions of HCMV genes targeted by antiviral therapies, significantly complicating the interpretation of resistance …
sa
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Accès ouvert
2025
article
OpenAlex
Abdulrahman Al-Saud, Ehab Abufarhaneh, Madain S. Alsanea, Reem Alameer et autres
Background: Cytomegalovirus (CMV) remains a formidable complication in small bowel transplantation (SBT) due to the graft’s high immunogenicity and profound immunosuppression required, with refractory disease representing a particularly devastating challenge. Case: We report an 18-year-old male who underwent SBT, complicated by recurrent …
sa
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Accès ouvert
2024
review
OpenAlex
Dalia Obeid, Feda A. Alsuwairi, Rawan Alnemari, Ahmed A. Al‐Qahtani et autres
BACKGROUND: Globally, sexually transmitted infections (STIs) collectively cause 2.3 million deaths and 1.2 million cases of cancer annually. However, the epidemiology of STIs in the Middle East and North Africa (MENA) is not well assessed because of various social and cultural factors. …
sa
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Accès ouvert
2024
article
OpenAlex
Dalia Obeid, Ahmed A. Al‐Qahtani, Reem S. Almaghrabi, Basma M. Alahideb et autres
BACKGROUND: Amidst the persistent global health threat posed by the evolving SARS-CoV-2 virus throughout the four-year-long COVID-19 pandemic, the focus has now turned to the Omicron variant and its subvariant, JN.1, which has rapidly disseminated worldwide. This study reports on the characteristics …
sa
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Accès ouvert
2024
article
OpenAlex
Feda A. Alsuwairi, Asma N. Alsaleh, Dalia Obeid, Ahmed A. Al‐Qahtani et autres
The genome of severe acute respiratory coronavirus-2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), has undergone a rapid evolution, resulting in the emergence of multiple SARS-CoV-2 variants with amino acid changes. This study aimed to sequence the whole genome of …
sa
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Accès ouvert
2024
article
OpenAlex
Madain S. Alsanea, Ahmed A. Al‐Qahtani, Reem S. Almaghrabi, Maha A. AlAbdulkareem et autres
Human cytomegalovirus (HCMV) infection may be asymptomatic in healthy individuals but can cause severe complications in immunocompromised patients, including transplant recipients. Breakthrough and drug-resistant HCMV infections in such patients are major concerns. Clinicians are first challenged to accurately diagnose HCMV infection and …
sa
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Accès ouvert
2023
article
OpenAlex
Abeer N. Alshukairi, Ahmed A. Al‐Qahtani, Dalia Obeid, Ashraf Dada et autres
RNA viruses, including SARS-CoV-2, rely on genetic mutation as a major evolutionary mechanism, leading to the emergence of variants. Organ transplant recipients (OTRs) may be particularly vulnerable to such mutations, making it crucial to monitor the spread and evolution of SARS-CoV-2 in …
sa
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Accès ouvert
2023
article
OpenAlex
Feda A. Alsuwairi, Asma N. Alsaleh, Madain S. Alsanea, Ahmed A. Al‐Qahtani et autres
SARS-CoV-2 genomic mutations outside the spike protein that may increase transmissibility and disease severity have not been well characterized. This study identified mutations in the nucleocapsid protein and their possible association with patient characteristics. We analyzed 695 samples from patients with confirmed …
sa
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Accès ouvert
2023
preprint
OpenAlex
Feda A. Alsuwairi, Asma N. Alsaleh, Madain S. Alsanea, Ahmed A. Al‐Qahtani et autres
Abstract SARS-CoV-2 genomic mutations outside the spike protein that may increase transmissibility and disease severity have not been well characterized. This study identified mutations in the nucleocapsid protein and their possible association with patient characteristics. We analyzed 695 samples from patients with …
sa, gb
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Accès ouvert
2023
article
OpenAlex
Fatimah S. Alhamlan, Dana Bakheet, Marie Fe F. Bohol, Madain S. Alsanea et autres
The global demand for rapid identification of circulating SARS-CoV-2 variants of concern has led to a shortage of commercial kits. Therefore, this study aimed to develop and validate a rapid, cost-efficient genome sequencing protocol to identify circulating SARS-CoV-2 (variants of concern). Sets …
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