Barry Digby

Aurantio-obtusin modulates Wilms Tumour 1 within the breast tumour microenvironment reducing immunosuppression and tumour growth

Zhilin Li, Dómhnall J O'Connor, Barry Digby, Pilib Ó Broin et autres

Cancer associated fibroblasts (CAFs) contribute to tumourigenesis and immune tolerance within the tumour microenvironment (TME). Therefore, inhibiting the pro-tumourigenic function of CAFs can be a viable therapeutic approach. However, targeting CAFs is challenging due to the lack of specific markers. The objective …

ie, cn, us (code pays fourni par la source)

Abstract P2-06-26: nf-hlamajority: a Nextflow pipeline for consensus MHC class I typing and its application to neoantigen identification in breast cancer stromal cells

Kevin M. Ryan, Domhnall O’Connor, Barry Digby, Laura R. Barkley et autres

Abstract Introduction: Cancer-associated fibroblasts (CAFs) are a heterogeneous cell type found in the tumour microenvironment (TME). CAFs can support tumour growth and metastasis and contribute to therapeutic resistance. They can also impact immune infiltration and immune responses in the TME. Therefore, therapeutic …

Computational approaches and challenges in the analysis of circRNA data

Barry Digby, Stephen P. Finn, Pilib Ó Broin

Circular RNAs (circRNA) are a class of non-coding RNA, forming a single-stranded covalently closed loop structure generated via back-splicing. Advancements in sequencing methods and technologies in conjunction with algorithmic developments of bioinformatics tools have enabled researchers to characterise the origin and function …

ie (code pays fourni par la source)

nf-core/circrna: a portable workflow for the quantification, miRNA target prediction and differential expression analysis of circular RNAs

Barry Digby, Stephen P. Finn, Pilib Ó Broin

BACKGROUND: Circular RNAs (circRNAs) are a class of covalenty closed non-coding RNAs that have garnered increased attention from the research community due to their stability, tissue-specific expression and role as transcriptional modulators via sequestration of miRNAs. Currently, multiple quantification tools capable of …

ie (code pays fourni par la source)

Epigenomic profiling at genome scale: from assays and analysis to clinical insights

Sarah Ennis, Barry Digby, Pilib Ó Broin

List of contributors

Lucia Altucci, Rosana Álvarez, Marianna Aprile, Fazila Asmar et autres

it, es, dk, us, ie, gb, fr, be, cn (code pays fourni par la source)