Richard A. Laforest

Feasibility of a portable PET system for interactive point‐of‐care (PoC) PET and ultrasound imaging

Samarth Aggarwal, Ling Cai, Suranjana Samanta, Yunlai Chen et autres

Abstract Background Positron emission tomography (PET) is a molecular imaging technology that has been used for detection and staging of diseases, and patient stratification to identify candidates for molecularly targeted drugs. Clinical PET/CT scanners are optimized for whole‐body diagnostic imaging instead of …

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Assessment of CCR2 PET as a Biomarker for Head and Neck Squamous Cell Carcinoma

Alexandria Li, Deborah Sultan, Gyu Seong Heo, Lisa Detering et autres

Because of the lack of prognostic biomarkers, most patients with head and neck squamous cell carcinoma (HNSCC) are diagnosed at an advanced stage of the disease, leading to poor overall survival. There is an unmet need to identify biomarkers for the assessment …

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Clinical Dosimetry Models and Pathway to Integration in Routine Nuclear Medicine Practice

Mercy Iyabode Akerele, Baljinder Singh, Justin Mikell, Komalpreet Kaur et autres

An increasing interest in radiopharmaceutical therapy (RPT), especially in reference to the theranostic framework incorporating both diagnostic and therapeutic components have been reported. Typically, this "theranostic approach" consists of a "matching pair" of radiopharmaceuticals, comprising a diagnostic partner labelled with positron or …

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Oral [18F]-Fluoro-Thia-Heptadecanoic Acid Positron Emission Tomography Reveals Mesenteric-to-Central Lymphatic Flow

Daniel D. Lee, Richard A. Laforest, Alexander Ushinsky, Michael L. Nickels et autres

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Quantitative Comparison of SPECT and PET Performance for Clinical Theranostic Applications

Isabella Salerno, Nicholas Dunn, Haley White, Wilnellys Miyazaki et autres

Radiopharmaceutical therapy is an emerging approach to treat metastatic disease, with the potential to enable personalized care through imaging. With the growing interest in quantitative imaging, there remains a need for systematic assessment of imageable radionuclides and scanner performance under comparable conditions. …

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Development of a Prototype AWSM-PET Device for Augmented Whole-Body PET Imaging and Initial Human Study

Yunlai Chen, Robert A. Mintzer, Sanghee Cho, Darren Pocci et autres

Augmented whole-body scanning via magnifying PET (AWSM-PET) is a technology that aims to enhance the image resolution and sensitivity of the clinical PET/CT scanner for whole-body imaging. This study presents the system design, performance evaluation, and results from phantoms and initial human …

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Longitudinal Trends in Myocardial Metabolic Uptake Following Stereotactic Arrhythmia Radioablation Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Positron Emission Tomography–Computed Tomography

Gerard Walls, Geoffrey D. Hugo, Rugheed Ghadban, Ali Javaheri et autres

Purpose Ventricular tachycardia (VT) is a life-threatening rhythm disturbance of the heart that has been shown to be amenable to treatment with stereotactic body radiation therapy, known as stereotactic arrhythmia radioablation (STAR). The metabolic impact of directly targeting arrhythmogenic regions of scarred …

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Feasibility of In-Vivo Dosimetry for Proton Therapy Using a Mobile Point-of-Care (PoC) PET Imaging System

Sunil Kumar Aggarwal, Li Cai, Yun Chen, Amy Qi et autres

Many new diagnostic PET imaging agents along with their companion radiopharmaceutical therapy (RPT) compounds have been adopted for cancer therapy. We recently constructed a compact and mobile PET device to enable interactive PET imaging capability at point-of-care (PoC) settings to support real-time …

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Development of a Portable PET System W/Real-Time Us Tracking for Interactive Point-of-Care Imaging

Sunil Kumar Aggarwal, Li Cai, Xiaoming Li, Yun Chen et autres

This study presents an updated Point-of-Care (PoC) PET system integrated with ultrasound (US), designed to enhance diagnostic imaging and image-guided interventions in environments where conventional PET/CT systems are impractical, such as operation room or intensive care units. We constructed a prototype dual-modality …

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Advances in SPECT and PET Reconstruction for Theranostics

Kweku S. Enninful, Bradley Girod, Richard A. Laforest, Daniel L.J. Thorek et autres

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Pediatric PET/MRI: Imaging Techniques, Indications, and Clinical Implementation

Sergios Gatidis, Maria Rosana Ponisio, Lise Borgwardt, Timothy M. Cain et autres

PET/MRI is a highly versatile and effective imaging modality in pediatric populations that requires dedicated study preparation, optimized imaging protocols, and structured interpretation to reach its full potential.

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NUCLIDE: A Novel Unsupervised Clustering-based Image Denoising and Enhancement for 4D Dynamic PET/MRI Data

Hamed Yousefi, Mahdjoub Hamdi, Richard A. Laforest, Matthew R. Brier et autres

Motivation: Dynamic PET denoising through deep learning struggles with contrast preservation and activity fidelity, compounded by black-box models and the absence of paired noisy-clean PET data. Current methods often oversmooth, obscuring crucial details. Goal(s): We propose an unsupervised 4D PET denoising approach …